CD11c is a member of the leukocyte integrin family of adhesion proteins. It is reported to be expressed in normal tissues, mainly on myeloid cells, for example, in bone marrow myelocytes, premyelocytes, metamyelocytes, non-segmented and segmented neutrophils with high levels reported on tissue macrophages and monocytes and with lowest levels in granulocytes. It is also reported to be expressed on NK cells, activated T cells, lymphoid cell lines, including hairy cell leukemias and a proportion of interdigitating dendritic cells.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
5D11
Concentration:
Greater than or equal to 30 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Barth TFE et al. Journal of Pathology. 2007; 211:305-313
References 2:
Venkatraman L et al. Modern Pathology. 2005; 18: 255A-256A 1183 Supplement 1
The CD163 molecule is a type I membrane protein also known as M130 antigen, Ber-Mac3, Ki-M8 or SM4. CD163 protein is restricted in its expression to the monocytic/macrophage lineage. It is reported to be present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhans cells. In addition, multi-nucleated cells within inflammatory lesions are reported not to express CD163 protein. The protein is upregulated by glucocorticoids and downregulated by the immunosuppressant cyclosporin A and by phorbol esters, while lipopolysaccharide, an inflammatory mediator, has no influence on expression. It has been proposed that a specific release mechanism of soluble CD163 antigen by human monocytes may play an important role in modulating inflammatory processes.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
10D6
Concentration:
Greater than or equal to 49 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Bronkhorst IH et al. Investigative Ophthalmology and Visual Science. 2011; 52(2):643-650
References 2:
Lau SK et al. American Journal of Clinical Pathology. 2004; 122(5):794-801
CD10 antigen, also called neprilysin, is a 100 kD cell surface metalloendopeptidase which inactivates a variety of biologically active peptides. It was initially identified as the common acute lymphoblastic leukemia antigen (CALLA) and was thought to be tumor-specific. Subsequent studies, however, have shown that CD10 antigen is expressed on the surface of a wide variety of normal and neoplastic cells. In other lymphoid malignancies, CD10 antigen is reported to be expressed on cells of lymphoblastic, Burkitt's and follicular lymphomas. CD10 antigen has been identified on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. It is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. (G. McIntosh et al. American Journal of Pathology. 154(1): 77-82 (1999)).
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
56C6
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Millar EK et al. Journal of Clinical Pathology 1999 52, 849-850
References 2:
McIntosh GG et al. American Journal of Pathology 1999 154(1), 7782
References 3:
Kaufmann O et al. American Journal of Clinical Pathology 1999 111(1), 117-122
References 4:
Endoh Y et al. Human Pathology 1999 30(7), 826-832
References 5:
Chu P and Arber DA. American Journal of Clinical Pathology 2000 113(3), 374382
CD31 antigen (PECAM-1) is a single chain transmembrane glycoprotein with a molecular weight of 130 to 140 kD. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the endothelial intracellular junction. The molecule has an extracellular domain that contains six Ig-like homology units of C2 subclass, typical of cell to cell adhesion molecules. This domain mediates endothelial cell to cell adhesion, plays a role in endothelial contact and may serve to stabilize the endothelial cell monolayer. The CD31 molecule also has a cytoplasmic domain with potential sites for phosphorylation after cellular activation. The properties of CD31 antigen suggest that it is involved in interactive events during angiogenesis, thrombosis and wound healing. Angiogenesis is essential for tumor growth and metastases.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
JC70A
Concentration:
Greater than or equal to 31 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
DeYoung BR et al. Journal of Clinical Pathology 1995; 22: 215-222
References 2:
Parums DV et al. Journal of Clinical Pathology 1990; 43: 752-757
References 3:
Fox SB et al. Journal of the National Cancer Institute 1997; 89: 1044-1049
References 4:
Engel CJ et al. American Journal of Surgical Pathology 1996; 20: 1260-1265
References 5:
Giatromanolaki A et al. Journal of Pathology 1996; 179: 80-88
ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.
Antibody Isotype:
IgG2b, kappa
Monosan Range:
MONXtra
Clone:
L453R
Concentration:
Greater than or equal to 449 mg/L
Storage buffer:
PBS with sodium azide
Storage:
2-8°C
References 1:
Orchard J et al. Leukaemia and Lymphoma 2005; 46(12):16891698
References 2:
Wang J et al. Applied Immunohistochemistry and Molecular Morphology 2005; 13(4):323332
References 3:
Mustelin T and Tasken K.Biochemical Journal 2003; 371:1527
References 4:
Van Oers N and Weiss A. Seminars in Immunology 1995; 7:227236
CD33 antigen is reported to appear on myelomonocytic precursor cells after CD34 antigen expression. It then continues to be expressed on both the myeloid and monocyte lineages, although it is reported to be absent on granulocytes. It has been reported that expression of CD33 is restricted to monocytes, premyelocytes, myeloid blasts, some acute undifferentiated leukemias and acute lymphoblastic leukemias.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
PWS44
Concentration:
Greater than or equal to 417 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Bradshaw EM et al. Nature Neuroscience. 2013, 16(7): 848 852
References 2:
Hoyer JD et al. American Journal of Clinical Pathology. 2008; 129(2): 316 323.
Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase of 58 kD located in the cell nucleus which catalyzes the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is reported to be expressed in primitive T and B lymphocytes of the normal thymus and bone marrow. The identification of TdT-positive cell populations in primary and secondary lymphoid organs during maturation of the immune system is one area of interest but it is the reported occurrence of high levels of enzyme activity in white blood cells and bone marrow in certain leukemias which is of particular interest.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
SEN28
Concentration:
Greater than or equal to 30 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Tai YC and Peh SC. FSingapore Medical Journal. 2003; 44(5):250-255
Mouse anti-Progesterone Receptor (A/B Forms), clone16 and SAN27
Antibody Type:
Monoclonal
Host Animal:
Mouse
Species Reactivity:
human
Immunogen:
Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor generating clone 16 and a prokaryotic recombinant protein corresponding to the 164 amino acid N-terminal region unique to the B form of the progesterone receptor generating clone SAN27.
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. In vitro studies have indicated that PRA and PRB can activate different target genes and that PRA, in some circumstances, may act as a dominant inhibitor of the function of PRB and other steroid hormone receptors. PRA and PRB are both expressed in normal breast. Most endometrial carcinomas, however, are reported to express only one isoform with either PRA or PRB being expressed. The cocktail has been formulated using two clones, clone 16, specific for PRA, and SAN27, specific for PRB.
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
EGFR.113
Concentration:
Greater than or equal to 26 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Lodge AJ et al. Journal of Clinical Pathology. 2003; 56(4):300304
References 2:
Sriplakich S et al. BJU Int. 1999; 83(4):498503
References 3:
Inoue K et al. Acta Med Okayama 1998; 52(6):305310
References 4:
Tungekar MF and Linehan J. Journal of Clinical Pathology. 1998; 51:583587
The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells. Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation. The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
HMB45
Concentration:
Greater than or equal to 10.8 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Swetter SM et al. Archives of Dermatology. 2004; 140:99-103
References 2:
Kapur RP et al. The Journal of Histochemistry and Cytochemistry. 1992; 40(2):207-212
References 3:
Gown AM et al. American Journal of Pathology. 1986; 123(2):195-203
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein of 52kD reported to be expressed in glial cells, for example, astrocytes and ependymal cells. In the peripheral nervous system, GFAP has been reported to be expressed in Schwann cells, enteric glial cells and satellite cells of human sensory ganglia and in neoplastic tissues GFAP has been reported to be expressed in astrocytomas and ependymomas. When using GFAP-GA5 the heat induced epitope retrieval (HIER) technique may improve staining in some cases.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
GA5
Concentration:
Greater than or equal to 70 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Louis ED et al. Brain 7. 2007; 130:3297-3307
References 2:
Barresi V et al. Archives of Pathology and Laboratory 8. Medicine 2006; 130:1208-1211
References 3:
Biondo B et al. Acta Neuropathologica 2004; 108:309-318
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
16
Concentration:
Greater than or equal to 324 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Hungermann D et al. Journal of Pathology 2002; 198: 487494
Polo-Like Kinase-1 (PLK1) also known as Serine/Threonine Protein Kinase 13 is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis and maintenance of genome stability. PLK-1 localizes to centrosomes and kinetochores where it plays a key role in late prophase and prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells. Overexpression of PLK-1 is associated with tumor development, with elevated levels of expression reported in non-small cell lung cancers, head and neck, gastric, breast, ovarian, colon and several other cancer types.
Langerin is a type II transmembrane C-type lectin which has mannose-binding specificity. It is a 40 kD protein restricted to Langerhans cells that is involved in the internalization of cell surface material in these immature dendritic cells. Dendritic cells are antigen-presenting cells that are required for initiation of a specific T cell-driven immune response. These cells are found in non-lymphoid tissue as immature cells whose primary function is to capture antigen through specialized surface membrane endocytic structures or through macropinocytosis. The dendritic cells migrate to secondary lymphoid tissue and mature into efficient antigen presenting cells. A part of the maturation process includes the loss of adhesion receptors such as E-cadherin and the disappearance of Birbeck granules.
Antibody Isotype:
IgG2b, kappa
Monosan Range:
MONXtra
Clone:
12D6
Concentration:
Greater than or equal to 20 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Yen EH et al. Journal of Pediatric Gastroenterology and Nutrition 2010;51(5): 584-592
References 2:
Musso T et al. PLoS ONE 2008; 3(9): e3271.1-10
References 3:
Rezk SA et al. American Journal of Surgical Pathology 2008;32(12):1868-1876
References 4:
ODonnell RK et al. Cancer Letters 2007;255(1):145-152
Chromogranin A is a 68 kD acidic protein which is reported to be widely expressed in neural tissues and in secretory granules of human endocrine cells, for example, parathyroid gland, adrenal medulla, anterior pituitary gland, islet cells of the pancreas and C cells of the thyroid. Chromogranin A expression has been reported in neuroendocrine tumors such as pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors and carcinoids.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5H7
Concentration:
Greater than or equal to 13 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Khandeparker SGS et al. Journal of Pediatric Neurosciences. 2013; 8(3): 239-242.
References 2:
Marcu M et al. Current Health Sciences Journal. 2010; 32: 37-42
Mismatch repair gene MutS Homolog 2 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutS protein homolog 2 (MSH2). MSH2 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
79H11
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Jensen UB et al. Breast Cancer Research and Treatment. 2009; 120 (3): 777-782
Thyroid peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of thyroid peroxidase (TPO) described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. Some studies have shown qualitative, as well as quantitative differences in thyroid peroxidase expression in thyroid cancer compared to normal tissue.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
AC25
Concentration:
Greater than or equal to 10.8 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Kimura S et al. Proceedings of the National Academy of Science USA 84: 5555-5559 (1987)
References 2:
De Micco C et al. Cancer 67(12): 30363041 (1991)
References 3:
Czarnocka B et al. Breast Journal Cancer 85(6): 875880 (2001)
References 4:
Tanaka T et al. Journal of Pathology 179: 8994 (1996)
Cytoplasmic actins are part of the microfilament system of cytoskeletal proteins. Smooth muscle actin is found in vascular walls, intestinal muscularis mucosae and muscularis propria and in the stroma of various tissues. Enzyme pretreatment may enhance staining in some cases. Human alpha smooth muscle actin. Reactive with smooth muscle cells in blood vessel walls, gut wall, myometrium and arrectores pili of skin. Myoepithelial cells such as those in breast and salivary gland also contain actin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
alpha sm-1
Concentration:
Greater than or equal to 4,5 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Skalli O et al. The Journal of Cell Biology. 1986; 103:2787-2796
References 2:
Ramos JG et al. Endocrinology. 2003; 144(7):3206-3215
References 3:
Suárez-Vilela D and Izquierdo-Garcia FM. Histopathology. 2003; 43(4):398-400
References 4:
Vicario JH et al. Rev Fed Arg Cardiol. 2002; 31:441-449
References 5:
Barry-Lane PA et al. Journal of Clinical Investigation. 2001; 108(10):1513-1522
Cyclin-dependent kinases are positive regulators of cell proliferation. p57 protein acts as a tumor suppressor to counter this. It is closely related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumors and tumors associated with the Beckwith-Wiedermann syndrome. There is increasing interest in p57 as a marker in gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
25B2
Concentration:
Greater than or equal to 19 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Kanthan R et al.World Journal of Surgical Oncology 2010; 8:10
References 2:
Sharifi N et al.Journal of the Turkish-German Gynecological Association 2009;10:39-42
References 3:
Maggiori MS and Peres LC. European Journal of Obstetrics and Gynecology and Reproductive Biology 2007; 135: 170-176
CD5 antigen is reported to be expressed on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed on T cells. CD5 antigen is also expressed by many T cell leukemias, lymphomas, activated T cells and on a subset of B cells located primarily in the mantle zones of normal lymph nodes. CD5 antigen expression is also reported in T cell acute lymphocytic leukemias (T-ALL), some B cell chronic lymphocytic leukemias (B-CLL) as well as B and T cell lymphomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
4C7
Concentration:
Greater than or equal to 76 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Leong FJW et al. The Journal of Histotechnology. 2002; 25(4):215-227
References 2:
Walsh R et al. Arch. of Pathol.and Lab.Medicine. 2001; 125(6):781-784
References 3:
Tateyama H et al. American Journal of Clinical Pathology. 1999; 111(2):235-240
References 4:
Dorfman DM & Shahsafaei A. Modern Pathology. 1997; 10(9):859-863
References 5:
Kaufmann O et al. American Journal of Clinical Pathology. 1997; 108(6):669-673
Alpha-methylacyl-CoA racemase (AMACR), also known as p504s, is a mitochondrial and peroxisomal enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism, and is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). Expression is granular and cytoplasmic. AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
EPMU1
Concentration:
Greater than or equal to 84 mg/L
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Lloyd M et al.FEBS Journal. 2008: 275;10891102
References 2:
Rubin M et al. J. of the Am. Med.Assoc. 2002: 287(13);16621670
The Ki67 antigen is a nuclear protein which is expressed in all active parts of the cell cycle (G1, S, G2 and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes. Thus, the presence of Ki67 antigen is strictly associated with the cell cycle and confined to the nucleus, suggesting an important role in the maintenance and/or regulation of the cell division cycle.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
K2
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mM sodium azide
The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
17C2
Concentration:
Greater than or equal to 51 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Curia MC et al. Modern Pathology. 2008; 21:7-14
References 2:
Ortega P et al. Clinical Cancer Research. 2008; 14(14):995-1001
References 3:
Daa T et al. J. of Exp.Clin.Cancer Research. 2005; 24(1):83-87
References 4:
Fadare O et al. World Journal of Surgical Oncology. 2005; 3(38)
References 5:
Gamachi A et al.Modern Pathology. 2003; 16(11):1124-1131
The CD23 molecule is the low affinity IgE receptor found on B cells.It is a membrane glycoprotein of 45 kD and is reported to be found on a sub-population of peripheral blood cells, B lymphocytes and on EBV-transformed B lymphoblastoid cell lines.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
1B12
Concentration:
Greater than or equal to 67 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Linderoth J et al. Clinical Cancer Research 2003; 9:722-728
References 2:
Peh SC et al. Singapore Medical Journal 2003; 44(4):185-191
References 3:
Maeda K et al. The Journal of Histochem. and Cytochem.2002; 50(11):1475-1485
References 4:
Watson P et al. Histopathology 2000 36(2), 145-150
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