Transcription factor E3 (TFE3) is a protein expressed in many cell types that are encoded by the TFE3 gene. This gene may be involved in chromosomal translocations that occur in some cancers.Xp11 translocation renal cell carcinomas (RCC) are a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus.1 Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma of uncertain differentiation. The hallmark of ASPS is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an ASPSCR1-TFE3 fusion gene responsible for an aberrant transcription factor presumably enabling pathogenesis.1-5
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-37
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Argani P. Am J Clin Pathol. 2006; 126:332-4
References 2:
Argani P, et al. Am J SurgPathol. 2003; 27:750-61
References 3:
Argani P, et al. Clin Lab Med.2005; 25:363-78
References 4:
Lazar AJ, et al. Histopathol. 2009; 55:750-5
References 5:
Lin G, et al. Arch Pathol Lab Med. 2015; 139:106-21
PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in some epithelial cell types of these mature tissues.1 It can be useful for marking several types of carcinoma including ovarian serous carcinoma, clear cell renal cell carcinoma, and papillary thyroid carcinoma.1-5 Additionally, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas and other sites.1-4
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ozcan A, et al. Mod Pathol. 2011; 24:751-64
References 2:
Laury AR, et al. Am J Surg Pathol. 2011; 35:816-26
References 3:
Nonaka, D et al. Am J Surg Pathol. 2008; 32:1566-71
CD19 is a glycoprotein on the surface of mature B cells, it works in conjunction with receptors and proteins to regulate B-cell signaling. CD19 is present in both normal and malignant B cells, and hence being valuable for the identification of B-cell neoplasms such as diffuse large B-cell lymphoma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-36
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Steinmetz OM, et al. Transplantation. 2007 15;84(7):842-50
References 2:
Teng YK, et al. Arthritis Rheum. 2007 ;56(12):3909-18
PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in some epithelial cell types of these mature tissues.1 It can be useful for marking several types of carcinoma including ovarian serous carcinoma, clear cell renal cell carcinoma, and papillary thyroid carcinoma.1-5 Additionally, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas and other sites.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-50
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ozcan A, et al. Mod Pathol. 2011; 24:751-64
References 2:
Laury AR, et al. Am J Surg Pathol. 2011; 35:816-26
References 3:
Nonaka, D et al. Am J Surg Pathol. 2008; 32:1566-71
CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein, found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms. Solubilized in plasma, CD163 functions as an anti-inflammatory signal and has many roles in disease processes that range from autoimmune conditions such as rheumatoid arthritis to atherosclerosis.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-26
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Buechler C, et al. J Leukoc Biol. 67:97-103 (2000)
References 2:
Kristiansen M, et al. Nature. 409:198-201 (2001)
References 3:
Etzerodt A. et al. Antioxid Redox Signal. 18: 2352-63 (2013)
C4d is a stable split product remnant of classical complement activation which becomes covalently bound to endothelium and basement membrane, after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jianghua C, et al. Clin Transplant. 2005; 19:785-91
References 2:
Kayler LK, et al. Transplantation. 2008; 85:813-20
References 3:
Ranjan P, et al. Nephrol Dial Transplant .2008; 23:1735-41
References 4:
Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76
References 5:
Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10
Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells. CD5 expression is useful in distinguishing mature T-cell neoplasms and differentiating among mature small lymphoid cell malignancies. Anti-CD5 does not react with granulocytes or monocytes.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
4C7
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jones NH, et al., Nature 1986;323: 346-349
References 2:
Tan SH et al. Br J Dermatol. 2003 Sep;149(3): 542-53
References 3:
Chang CC et al. Mod Pathol. 2002 Oct;15(10): 1051-7
References 4:
Hatano B et al. Pathol Int. 2002 May-Jun;52(5-6): 400-5
References 5:
West RB et al. Am J Clin Pathol. 2002 Apr;117(4): 636-43
CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin gene superfamily. While its precise function is not known, it is suggested that CD7 plays a role in T-cell interactions as it is one of the earliest T-cell lineage associated antigens expressed during T-cell ontogeny. CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoid and myeloid progenitors. CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukemias, and is therefore a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T cell neoplasms, it is the most common pan-T antigen to be aberrantly absent and its absence in a T cell population is a useful pointer to a neoplastic conversion.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-56
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hodak E, et al. J Am Acad Derma¬tol. 2006 Aug;55(2):276-84
References 2:
Stillwell R, et al. Immunol Res. 2001; 24:31-52
References 3:
Schanberg LE, et al. Proc Natl Acad Sci USA. 1991; 88:603-7
Common acute lymphoblastic leukemia antigen (CALLA / CD10) is a useful marker for the characterization of childhood leukemia and B cell lymphomas. This antibody reacts with antigen of lymphoblastic, Burkitts, and follicular lymphomas; and chronic myelocytic leukemia. Also, Anti-CD10 detects the antigen of glomerular epithelial cells and the brush border of the proximal tubules; this characteristic may be helpful in interpreting renal ontogenesis in conjunction with other markers. Other non-lymphoid cells that are reactive with CD10 are breast myoepithelial cells, bile canaliculi, neutrophils and small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
56C6
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Maguer-Satta V, et al.. Stem Cells. 2011; 29:389-96
Anaplastic lymphoma kinase (ALK) is a novel receptor protein-tyrosine kinase. ALK can create a fusion protein with a nuclear protein gene called nucleophosmin (NPM) via the amino terminus of NPM and the catalytic domain of ALK. The product of this fusion protein is oncogenic.1 Studies have found this chromosomal translocation in most anaplastic large-cell non-Hodgkin's lymphomas, making ALK a good marker for anaplastic large cell lymphomas
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
ALK-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL). Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1), an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t(11;14)(q13;q32).
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-58
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD33, also known as gp67 or SIGLEC-3, is a 67 kDa glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. Although the precise physiological function of CD33 is unknown, it may mediate cell to cell adhesion and modulate inflammatory and immune response. In normal tissue, anti-CD33 labels myeloid cells (especially myeloid precursors), liver Kupffer cells, lung alveolar macrophages, and placental syncytiotrophoblasts. In neoplastic tissue, anti-CD33 is useful for the identification of acute myeloid leukemia.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
PWS44
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Freeman SD, et al. Blood. 1995; 85:2005-12
References 2:
Laszlo GS, et al. Oncotarget. 2016; 7:43281-94
References 3:
Crocker, PR et al. Biochem Soc Symp 2002; 69:83-96
Blood group Lewis carbohydrate determinants are oligosaccharides on glycolipids and glycoproteins. In healthy individuals the LewisY antigen is a type 2 antigen usually only expressed in low levels of a few cell types such as some epithelial cells. Reportedly these antigens are aberrantly expressed in high levels in many carcinomas. Anti-BG8, LewisY reactivity in immunohistochemistry is seen in carcinomas of the breast, lung, and colon
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
F3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Davidson B, et al. Virchows Arch. 1999; 435:43-9
References 2:
King JE, et al. Histopathology. 2006; 48:223-32
References 3:
Marchevsky AM et al. Appl Immunohistochem Mol Morphol. 2007; 15:140-4
Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system. In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid follicular dendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, and salivary gland as well as basal epithelium of the respiratory system. NGFR has been shown to be a reliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants Anti-NGFR labels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignancies of the breast.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-21
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Thompson SJ. Am J Clin Pathol. 1989; 92:415-23
References 2:
Reis-Filho JS, et al. Mod Pathol. 2006; 19:307-19
References 3:
Lazova R, et al. J Am Acad Dermatol. 2010; 63:852-8
Anti-GCDFP-15, mouse monoclonal (23A3), and anti-mammaglobin, mouse monoclonal (304-1A5) and rabbit monoclonal (31A5), is an antibody cocktail. GCDFP-15 is a 15 kDa glycoprotein which is localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. Mammaglobin (10 kDa) is a breast-associated glycoprotein distantly related to the secretoglobin family that includes human uteroglobin and lipophilin.This antibody cocktail is useful in identifying breast carcinoma.
Antibody Isotype:
IgG2a/IgG1/IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
23A3+(304-1A5+31A5)
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Cohen, C et al. Arch Pathol Lab Med. 1993; 117:291-4
References 2:
Bhargava R, et al. Am J Clin Pathol. 2007; 127:103-13
References 3:
Takeda Y, et al. Arch Pathol Lab Med. 2008; 132:239-43
References 4:
Tornos C, et al. Am J Surg Pathol. 2005; 29:1482-9
CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are anti-CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.1,3 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. Anti-CD23 is expressed in activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
1B12
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kaiserlian, D, et al., Immunology 1993;80:90-95
References 2:
Aubry, JP et al., Oxford Univ Press- Oxford, NY, Tokyo 1987:417-419
References 3:
Pallesen G, Oxford Univ Press-Oxford, NY, Tokyo 1987:383-386
References 4:
Pezzella F et al. Br j Haematol. 2000 Feb;108(2): 369-76
References 5:
Kurtin PJ et al. Am J Clin Pathol. 1999 Sep;112(3): 319-29
IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%).
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-44
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Sakata N, et al., Am J Surg Pathol. 2008; 32:553-9
References 2:
Dhobale S, et al., J Clin Rheumatol. 2009; 15:354-7
References 3:
Li Y, et al., Pathol Int. 2009; 59:636-41
References 4:
Koyabu M et al., J Gastroenterol. 2010; 45:732-41
References 5:
Kamisawa T, et al., World J Gastroenterol. 2009; 21:2357-60
Anti-Cytokeratin 5 & 6 is a marker for eptihelioid mesotheliomas. Anti-Cytokeratin 5 & 6 stains the cytoplasm of such cells. Anti-TTF-1 stains the nuclei in the case of lung adenocarcinomas and is negative in nearly all mesotheliomas. The nuclear vs. cytoplasmic staining pattern of this cocktail can be useful in distinguishing between mesothelioma and adenocarcinoma of the lung.
Antibody Isotype:
IgG1/IgG1/IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
D5/16B4 & 8G7G3/1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ordóñez NG. Am J Surg Pathol. 1998; 22:1215-21
References 2:
Jang KY, et al. Anal Quant Cytol Histol; 2001; 23:400-4
References 3:
Srodon M, et al. Hum Pathol. 2002; 33:642-5
References 4:
Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8
References 5:
Bejarano PA, et al. Arch Pathol Lab Med. 2003; 127:193-5
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1 that differ by the variable inclusion of amino acids are potentially produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics [medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs)] is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-27
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Bourdeaut F, et al. J Pathol. 2007; 211:323-30
References 2:
Fowler DJ, et al. Fetal Pediatr Pathol. 2006; 25:159-68
References 3:
Haberler C, et al. Am J SurgPathol. 2006; 30:1462-8
References 4:
Janson K, et al. Pediatr Blood Cancer. 2006 Sep:47(3):279-84
Anti-caldesmon is a regulatory protein found in smooth muscle and other tissues which interacts with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle, myofibroblastic, and myoepithelial differentiation. Anti-caldesmon has also been used to differentiate epithelioid mesothelioma from serous papillary carcinoma of the ovary.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
E89
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Miettinen M, et al. Arch Pathol Lab Med. 2006; 130:1466-78
References 2:
Watanabe K, et al. Hum Pathol. 1999; 30:392-6
References 3:
McCluggage WC. Adv Anat Pathol. 2004; 11:162-71
References 4:
Comin CE, et al. Am J Surg Pathol. 2006; 30:463-9
References 5:
Comin CE, et al. Am J Surg Pathol. 2007; 31:1139-48
The antibody reacts with progesterone receptor forms alpha and beta. This antibody stains nuclei in breast, ovarian and endometrial epithelia, as well as myometrial nuclei. Since the early 1990s the immunohistochemical (IHC) assay determination of progesterone receptor status has replaced the dextran-coated charcoal method as a prognostic indicator in breast carcinoma. IHC has shown to be superior in prognostic significance when using any one of several available methods of quantitation using this technique.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
Y85
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Dabbs D. Diagnostic Immunohistochemistry, 2nd edition. p 728-32
References 2:
Dunnwald LK, et al. Breast Cancer Res. 2007;9(1):R6
References 3:
Leong A S-Y, et al. Manual of diagnostic immunohistochemistry, 2nd edition. p 375-76
Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD) with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin. Antithrombomodulin has demonstrated positivity in benign vascular tumors such as hemangioma and most malignant vascular tumors (Kaposis sarcoma and epitheliod hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of antithrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas. Anti-thrombomodulin is immunoexpressed in a variety of other tumors including urothelial cell carcinomas
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
1009
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Acebo E, et al. Histol. Histopath. 2001; 16:1031-6
References 2:
Appleton MA, et al. Histopathology. 1996; 29:153-7
References 3:
Attanoos RL, et al. Histopathology. 1996; 29:209-15
References 4:
Attanoos RL, et al. Histopathology. 2001; 39:584-8
Carbonic Anhydrase (CA IX) is part of a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2.1 Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach.1 Data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) making it a useful marker for this type of tumor.2
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP161
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Leppilampi M, et al. World J Gastroenterol. 2003; 9:1398-1403
References 2:
Gupta R, et al. Am J Surg Pathol. 2009; 33:241-7
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