The c-erbB-2 oncoprotein is closely related in structure to the epidermal growth factor receptor and is a member of a large family of cell surface growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable in a proportion of breast and other adenocarcinomas as well as transitional cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell types in a range of normal human fetal and adult tissues, including breast, stomach and ovary. CB11 detects the internal domain of the c-erbB-2 oncoprotein.
Estrogen receptor (ER) content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. The introduction of highly specific monoclonal antibodies to ER has allowed the determination of receptor status of breast tumors to be carried out in routine histopathology laboratories.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
6F11
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Bevitt DJ et al. Journal of Pathology 1997; 183(2), 228232
References 2:
Kaplan, PA et al. Am J Clin Pathol 2005: 276280
References 3:
Zafrani B et al. Histopathology 2000; 37(6), 536545
References 4:
Harvey JM et al. Journal of Clinical Oncology 1999; 17(5), 14741481
References 5:
Khan SA et al.European Journal of Cancer 2000; 36(Suppl 4), S27S28
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
16
Concentration:
Greater than or equal to 324 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Hungermann D et al. Journal of Pathology 2002; 198: 487494
Mouse anti-Progesterone Receptor (A/B Forms), clone16 and SAN27
Antibody Type:
Monoclonal
Host Animal:
Mouse
Species Reactivity:
human
Immunogen:
Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor generating clone 16 and a prokaryotic recombinant protein corresponding to the 164 amino acid N-terminal region unique to the B form of the progesterone receptor generating clone SAN27.
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. In vitro studies have indicated that PRA and PRB can activate different target genes and that PRA, in some circumstances, may act as a dominant inhibitor of the function of PRB and other steroid hormone receptors. PRA and PRB are both expressed in normal breast. Most endometrial carcinomas, however, are reported to express only one isoform with either PRA or PRB being expressed. The cocktail has been formulated using two clones, clone 16, specific for PRA, and SAN27, specific for PRB.
Thyroglobulin is a heavily glycosylated protein of 670kD composed of two identical subunits and is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin provides iodination sites for the formation of the thyroid hormones.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
1D4
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Male DK et al. Immunology. 54: 419427 (1985)
References 2:
Shepherd PS et al. European Journal of Nuclear Medicine. 10: 291295 (1985)
References 3:
Chan CTJ et al. Clinical and Experimental Immunology. 70: 516523 (1987)
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
EGFR.113
Concentration:
Greater than or equal to 26 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Lodge AJ et al. Journal of Clinical Pathology. 2003; 56(4):300304
References 2:
Sriplakich S et al. BJU Int. 1999; 83(4):498503
References 3:
Inoue K et al. Acta Med Okayama 1998; 52(6):305310
References 4:
Tungekar MF and Linehan J. Journal of Clinical Pathology. 1998; 51:583587
This monoclonal antibody recognizes both wild type and mutant forms of human p53 protein under denaturing and non-denaturing conditions. The epitope recognized by clone DO-7 can be destroyed by prolonged fixation in buffered formalin. The heat induced epitope retrieval technique may improve staining in some cases.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
DO-7
Concentration:
Greater than or equal to 22 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Tiniakos DG et al. Cytopathology. 1996; 7(3): 178186
References 2:
Yoshida T et al. Journal of Pathology. 2003; 199(2):166175
References 3:
Burns ASYW et al. British Journal of Cancer. 2002; 86(7):11171123
References 4:
Tweddle DA et al. American Journal of Pathology. 2001; 158(6): 20672077
References 5:
Fernando SS et al. International Journal of Surgical Pathology. 2000; 8(3):213222
p63 is a type II integral membrane protein predominantly localized in the rough endoplasmic reticulum. p63 is reported to be expressed in a number of normal tissues including proliferating cells of the epithelium, cervix, urothelium and prostate. p63 is also reported to be expressed in most poorly differentiated squamous cell carcinomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
7JUL
Concentration:
Greater than or equal to 208 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Mahalingam M et al. Modern Pathology. 2010; 23:713-719
References 2:
Shah VI et al. Histopathology. 2006; 48:683-691
References 3:
Yen CC et al. World Journal of Gastroenterology. 2005; 11(9):1267-1272
References 4:
Bilal H et al. The Journal of Histochemistry and Cytochemistry. 2003; 51(2):133-139
Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor suppressor gene is present in many cells and may indirectly regulate cell growth by activating the transcription factor ATF-2. Activation of ATF-2 initiates expression of TGF-beta2, which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may potentially play a role in the development of a number of malignant tumors.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
13A10
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Jares P et al. Journal of Pathology. 182: 160-166 (1997)
References 2:
Karpeh MS et al. British Journal of Cancer. 72: 986-991 (1995)
References 3:
Stefanini M et al. Nature. 216: 173-174 (1967)
References 4:
Bartek J et al. Oncogene. 7: 101-108 (1992)
References 5:
Sanders BM et al. British Journal of Cancer. 60: 358-365 (1989)
The gene encoding WAF1, also termed p21, is transcriptionally regulated by the suppressor protein, p53. Overexpression of WAF1 is growth suppressive, possibly by inhibiting the activity of cyclin/CDK complexes. One consequence of WAF1 binding to cyclin/CDK is the inhibition of Rb protein phosphorylation. Induction of WAF1 expression requires wild type p53 activity in cells undergoing p53 dependent G1 arrest or apoptosis. Mutation of the p53 gene is a common event in human cancer and results in the failure to produce WAF1. The effect of this may lead to uncontrolled cell proliferation.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
4D10
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mM sodium azide
Storage:
2-8°C
References 1:
Göhring UJ et al. Journal of Clinical Pathology. 54: 866870 (2001)
References 2:
Schwerer MJ et al. Journal of Clinical Pathology. 54: 871876 (2001)
References 3:
Tweddle DA et al. American Journal of Pathology. 158 (6): 20672077 (2001)
References 4:
Garcia JF et al. Histopathology. 30: 120125 (1997)
Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
bcl-2/100/D5
Concentration:
Greater than or equal to 56 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Von Haefen C et al. Oncogene. 2002; 21(25):4009-4019
References 2:
Takes RP et al.Journal of Pathology. 2001; 194:298-302
References 3:
Tweddle DA et al. American Journal of Pathology. 2001; 158(6): 2067-2077
References 4:
Ramani P et al. Journal of Pathology. 1994; 172:273-278
References 5:
Pezzella F et al. American Journal of Pathology. 1990; 137(2):225-232
The c-kit proto-oncogene encodes a transmembrane receptor with tyrosine kinase activity, c-kit (CD117), which is closely-related to the platelet-derived growth factor receptor family. c-kit plays a role during hematopoiesis, gametogenesis and melanogenesis. The expression of CD117 antigen is of particular interest in the study of gastrointestinal stromal tumors (GIST), small lung cell carcinomas and in melanomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
T595
Concentration:
Greater than or equal to 30 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Sawyer EJ et al. Journal of Pathology. 2003; 200:5964
The D-type cyclins are a family of proteins which function primarily by regulating the activity of cyclin dependent kinases in the G1 phase of the cell cycle. Cyclin D1, a protein of 36 kD, is also known as PRAD1 or bcl-1. Maximum expression of cyclin D1 occurs at a critical point in mid to late G1 phase of the cell cycle. The cyclin D1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphomas due to the chromosomal translocation t(11;18).
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
P2D11F11
Concentration:
Greater than or equal to 19 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
McIntosh GG et al. Oncogene. 1995; 11:885891
References 2:
Saiz AD et al. Journal of Pathology. 2002; 198(2):157162
References 3:
Mommers ECM et al. Journal of Pathology. 2001; 194(3):327333
References 4:
Saito T et al. Journal of Pathology. 2001; 195(2):222228
References 5:
Sheyn I et al. Human Pathology. 1997; 28(3):270276
The Ki67 antigen is a nuclear protein which is expressed in all active parts of the cell cycle (G1, S, G2 and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes. Thus, the presence of Ki67 antigen is strictly associated with the cell cycle and confined to the nucleus, suggesting an important role in the maintenance and/or regulation of the cell division cycle.
Clone MTB1 detects cortical thymocytes, Langerhans cells in epidermis, interdigitating cells of dermis and interdigitating cells of stratified squamous epithelium of tonsil. Clone MTB1 may also detect small focal groups of lymphocytes outside the germinal centers of tonsil indicating a cross-reaction with CD1b antigen.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
MTB1
Concentration:
Greater than or equal to 16 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Dultra FK et al. Journal of Oral Pathology and Medicine. 2012; 41(1):47-53
References 2:
Natamoto Y et al. Clinical and Experimental Immunology. 2007; 147:296-305
References 3:
Hubert P et al. Journal of Pathology. 2005; 206:346-355
References 4:
Rho NK et al. British Journal of Dermatology. 2004; 151:119-125
References 5:
Soilleux EJ et al. Journal of Pathology. 2001; 195(5):586-592
The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is also generally CD4 positive.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
4B12
Concentration:
Greater than or equal to 405 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Arnould L et al. British Journal of Cancer 2006; 94:259-267
References 2:
Choi HJ et al. British Journal of Dermatology 2006; 154:419-425
References 3:
Lapperre TS et al. Thorax 2006; 61:115-121
References 4:
Willemse BWM et al. Respiratory Research 2005; 6:38
References 5:
Suzuki A et al. Journal of Pathology 2002; 196:37-43
CD5 antigen is reported to be expressed on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed on T cells. CD5 antigen is also expressed by many T cell leukemias, lymphomas, activated T cells and on a subset of B cells located primarily in the mantle zones of normal lymph nodes. CD5 antigen expression is also reported in T cell acute lymphocytic leukemias (T-ALL), some B cell chronic lymphocytic leukemias (B-CLL) as well as B and T cell lymphomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
4C7
Concentration:
Greater than or equal to 76 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Leong FJW et al. The Journal of Histotechnology. 2002; 25(4):215-227
References 2:
Walsh R et al. Arch. of Pathol.and Lab.Medicine. 2001; 125(6):781-784
References 3:
Tateyama H et al. American Journal of Clinical Pathology. 1999; 111(2):235-240
References 4:
Dorfman DM & Shahsafaei A. Modern Pathology. 1997; 10(9):859-863
References 5:
Kaufmann O et al. American Journal of Clinical Pathology. 1997; 108(6):669-673
The CD8 molecule is composed of two chains and has a molecular weight of 32 kD. It is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35% of human peripheral blood lymphocytes.The CD8 antigen is reported to be detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15-30% of bone marrow cells.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
4B11
Concentration:
Greater than or equal to 28 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Kemp RA et al. Journal of Experimental & Clinical Cancer Research. 2011;30(1):78
References 2:
Michel S et al. British Journal of Cancer. 2008;99(11):1867-1873
References 3:
Williamson SLH et al. American Journal of Pathology 1998,152(6):1421-1426
CD10 antigen, also called neprilysin, is a 100 kD cell surface metalloendopeptidase which inactivates a variety of biologically active peptides. It was initially identified as the common acute lymphoblastic leukemia antigen (CALLA) and was thought to be tumor-specific. Subsequent studies, however, have shown that CD10 antigen is expressed on the surface of a wide variety of normal and neoplastic cells. In other lymphoid malignancies, CD10 antigen is reported to be expressed on cells of lymphoblastic, Burkitt's and follicular lymphomas. CD10 antigen has been identified on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. It is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. (G. McIntosh et al. American Journal of Pathology. 154(1): 77-82 (1999)).
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
56C6
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Millar EK et al. Journal of Clinical Pathology 1999 52, 849-850
References 2:
McIntosh GG et al. American Journal of Pathology 1999 154(1), 7782
References 3:
Kaufmann O et al. American Journal of Clinical Pathology 1999 111(1), 117-122
References 4:
Endoh Y et al. Human Pathology 1999 30(7), 826-832
References 5:
Chu P and Arber DA. American Journal of Clinical Pathology 2000 113(3), 374382
CD13 antigen, also known as aminopeptidase N, is a member of type II integral membrane metalloproteases, which also includes the leukocyte antigens CD10, CD26, CD73 and BP-1. CD13 antigen is a receptor for the coronaviruses which cause respiratory disease in humans and several animal species. The antigen functions as a zinc-binding metalloprotease which plays a role in cell surface antigen presentation by trimming the N-terminal amino acids from MHC class II-bound peptides. CD13 antigen is reported to be expressed on granulocytes, monocytes and their precursors, most acute myeloid leukemias and a smaller proportion of acute lymphoid leukemias. Non-hematopoietic cells which express CD13 antigen include epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
38C12
Concentration:
Greater than or equal to 19 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Terauchi M et al.BMC Cancer 2007; 7:140
References 2:
Agis H et al. Journal of Clinical Pathology 2006; 59 (4):396-402
References 3:
Röcken C et al. Journal of Clinical Pathology 2005; 58 (10):1069-1075
Prokaryotic recombinant protein corresponding to the external domain of the CD16 molecule, common to both the transmembrane form and the GPI-linked form.
CD16 antigen has a molecular weight of 50 to 70 kD and is a low affinity Fc receptor for complexed IgG, Fc/gamma RIII, expressed on natural killer (NK) cells, granulocytes, activated macrophages and a subset of T cells expressing alpha-beta or gamma-delta T cell antigen receptors. The CD16 antigen exists both as a glycosyl-phosphatidylinositol (GPI)-anchored protein in polymorphonuclear cells and as a transmembrane protein in NK cells.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
2H7
Concentration:
Greater than or equal to 18 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Qubaja M et al. Virchows Archiv. 2009; 454(4):411-419
References 2:
Wicherek L et al. Reproductive Biology and Endocrinology. 2006; 14; 4:41
References 3:
Lee SF et al. Molecular and Cell Biology. 1999; 19(11):7399-7409
The CD20 antigen is a non-glycosylated phosphoprotein of approximately 33kD which is expressed on normal and malignant human B cells and is thought to act as a receptor during B cell activation and differentiation. CD20 antigen has been reported to be expressed on normal B cells from peripheral blood, lymph node, spleen, tonsil, bone marrow, acute leukemias and chronic lymphocytic leukemias.An intracytoplasmic epitope localised on the human CD20 molecule. Reacts predominantly with a 33 kD polypeptide, but also with a minor component of 30 kD.
Antibody Isotype:
IgG2a, kappa
Monosan Range:
MONXtra
Clone:
L26
Concentration:
Greater than or equal to 95 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Mason DY et al. American Journal of Pathology. 1990; 136(6):12151222
References 2:
Cartun RW et al. American Journal of Pathology. 1987; 129(3):415421
References 3:
Norton AJ and Isaacson PG. Journal of Clinical Pathology. 1987; 40:14051412
References 4:
Ishii Y et al. Clinical Experimental Immunology. 1984; 58:183192
CD21 antigen is a type I integral membrane glycoprotein of molecular weight 140 kD, which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells, is involved in transmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias but is absent on T lymphocytes, monocytes and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and mantle cell lymphomas, mature leukemias and lymphomas.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
2G9
Concentration:
Greater than or equal to 326 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Dupin N et al. Proceedings of the National Academy of Sciences USA. 1999; 96(8); 45464551.
The CD23 molecule is the low affinity IgE receptor found on B cells.It is a membrane glycoprotein of 45 kD and is reported to be found on a sub-population of peripheral blood cells, B lymphocytes and on EBV-transformed B lymphoblastoid cell lines.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
1B12
Concentration:
Greater than or equal to 67 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Linderoth J et al. Clinical Cancer Research 2003; 9:722-728
References 2:
Peh SC et al. Singapore Medical Journal 2003; 44(4):185-191
References 3:
Maeda K et al. The Journal of Histochem. and Cytochem.2002; 50(11):1475-1485
References 4:
Watson P et al. Histopathology 2000 36(2), 145-150
The CD38 molecule is a type II single transmembrane glycoprotein with a molecular weight of 46 kD. It is an ectoenzyme with the activities of ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD glycohydrolase and is involved in both the formation and hydrolysis of cADPR, a second messenger that regulates the mobilization of intracellular Ca2+ ions. Although the CD38 molecule was originally identified as a T lymphocyte differentiation antigen, it is reported to be expressed in a wide range of cells and tissues. CD38 antigen can deliver potent growth and differentiation signals to lymphoid and myeloid cells. It is found on immature cells of the B and T cell lineages but not on most mature resting peripheral lymphocytes. It is also present on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, Ig-secreting plasma cells, monocytes, NK cells, erythroid and myeloid progenitors in the bone marrow and brain cells. CD38 antigen has also been reported in neurofibrillary tangles, the pathological indicator of Alzheimer's disease that occurs in the neuronal perikarya and proximal dendrites.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
SPC32
Concentration:
Greater than or equal to 46 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Krukemeyer MG et al. Transplantationsmedizin. 2003; 15:4046
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