Anti-CEA specifies a group of proteins in the Carcinoembryonic Antigen (CEA) family of proteins which are present in the epithelia of various types and tumors (both benign and malignant) derived from such epithelia. Such tissues are represented by the epithelia of colon, bronchus, alveoli, breast, pancreas, biliary tract, superficial layer and parietal layers of the stomach. Predominately biliary canaliculi are labelled in the liver and this factor is useful in the diagnosis of hepatocelluar carcinoma. Anti-CEA has been quite useful in differentiating adenocarcinoma of the lung vs. mesothelioma. Associated products: CK 5/6, Calretinin, WT-1, E-Cadherin, TTF-1, TAG-72, EMA, CK 20
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Shield PW, et al. Am J Clin Pathol. 1996; 105:157-62
References 2:
Sheahan K, et al. Am J Clin Pathol. 1990; 94:157-64
Anti-CEA is employed as a tool to assist in the distinction between adenocarcinoma and mesotheliomas, along with other markers such as calretinin, CK 5/6, D2-40, HBME-1, Napsin A, MOC31, and Ber-EP4. Anti-CEA positivity is seen in adenocarcinomas from the lung and colon, as well.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
CEA31
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Go, VLW, et al., Cancer 1976;37:562-566
References 2:
Delellis, RA, et al., Am J Clin Pathol 1978;50:587-594
References 3:
Abutaily AS et al. J Clin Pathol. 2002 Sep;55(9):662-8
References 4:
Bhatnagar J et al. Anticancer Res. 2002;22(3):1849-57
References 5:
Carella R. et al. Am J Surg Pathol. 2001 Jan;25(1):43-50
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells. It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma. ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineageassociated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL. Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers. Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
B-A38
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Chilosi M, et al. Mod Pathol. 1999; 12:1101-6
References 2:
Sebestyén A, et al. Br J Haematol. 1999; 104:412-9
References 3:
Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8
References 4:
OConnell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
References 5:
Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47
CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein, found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms. Solubilized in plasma, CD163 functions as an anti-inflammatory signal and has many roles in disease processes that range from autoimmune conditions such as rheumatoid arthritis to atherosclerosis.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-26
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Buechler C, et al. J Leukoc Biol. 67:97-103 (2000)
References 2:
Kristiansen M, et al. Nature. 409:198-201 (2001)
References 3:
Etzerodt A. et al. Antioxid Redox Signal. 18: 2352-63 (2013)
CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposis sarcoma, and tumors of smooth muscle origin.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
YR145
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Sircar K, et al. AM J Surg Pathol 23(4):377-389,1999
References 2:
Miettinen M et al. Am J Surg Pathol 24(2):211-222, 2000
References 3:
Miettinen M. et al. Am J Surg Pathol 23(9): 1109-1118
The antibody is a B-cell marker that is generally used to complement CD20. This antibody will stain many of the same lymphomas as CD20, but also is more likely to stain precursor B-lymphoid leukemias than CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Anti-CD79a will stain many cases of acute promyelocytic leukemia (FAB-M3), but only rarely stains other types of myeloid leukemia.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
JCB117
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mason DY, et al., Eur J Immun; 22:2753-2756 (1992)
References 2:
Lin BT, Weiss LM. Hum Pathol.; 28(9):1083-90 (1997)
References 3:
Pilozzi E et al. J Pathol.; 186(2):140-3 (1998)
References 4:
Kurtin PJ et al. Am J Clin Pathol.; 112(3):319-29 (1999)
References 5:
Blakolmer K et al. Mod Pathol.; 13(70:766-72 (2000)
The antibody marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; lymphomas are negative or show few granules. This antibody may be useful for the identification of myelomonocytic and histiocytic tumors. Since this detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also stain.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Kp-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and the majority of malignant melanomas. Anti-CD63 is a useful immunohistochemical marker for the identification of malignant melanoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
NKI/C3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Azorsa DO, et al. Blood. 1991; 78:280-4
References 2:
Barrio MM, et al. Hybridoma. 1998; 17:355-64
References 3:
Demetrick DJ,et al. J Natl Cancer Inst. 1992; 84:422-9
CD61 also known as integrin beta chain beta 3 (ITGB3) is an integrin cell-surface protein associated with cellular adhesion and cell-surface mediated signaling. Immunohistochemical staining for CD61 can be useful in evaluating normal and abnormal megakaryocytes, which can aide in the identification of some hematopoietic malignancies. Anti-CD61 reactivity is also seen in platelets, osteoclasts and macrophages.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
2f2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Duperray A et al. Blood. 1989 Oct; 74(5):1603-11
References 2:
Goldman BI et al. Modern Pathology 14:589-594 (2001)
References 3:
Thiele J et al. Virchows Archiv B Cell Pathol (1990) 58:295-302
CD57, also known as HNK-1 (human natural killer-1), is a cell surface carbohydrate epitope expressed on terminally differentiated T-cells and subsets of natural killer (NK) cells.1 It has also been identified on cells of neural crest origin.2 Anti-CD57 is often used to visualize the non-neoplastic bystander T-cells that may form rosettes around the neoplastic lymphocyte-predominant (LP) cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).3
Antibody Isotype:
IgM-k
Monosan Range:
MONOSAN Ready To Use
Clone:
NK1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kared H, et al. Cancer Immunol Immunother. 2016; 65:441-52
References 2:
Nielsen CM, et al. Front Immunol. 2013; 4:422
References 3:
Sattarzadeh A, et al. Exp Hematol Oncol. 2015; 4:27
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. CD56 is involved in cellcell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues. In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms. well
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
123C3.D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Langdon, SP, et al. Cancer Research 1988;48(21):6161-6165
References 2:
Moolenaar, CE, et al. Cancer Research 1990;50(4):1102-1106
References 3:
Sumi M et al. Leuk Lymphoma. 2003 Jan; 44(1): 201-4
References 4:
Kibbelaar, RE, et al. Euro J of Cancer 1991;27(4):431-435
References 5:
Michalides, R, et al. International J of Cancer Sup 1994;8:34-37
Anti-CD45RO labels an isoform of the CD45 antigen also known as leukocyte common antigen. Anti-CD45RO reacts with thymocytes, mature activated T-cells, and a subpopulation of resting T-cells while showing no reactivity with B-cells, making this antibody helpful in identifying T-cell neoplasms.
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
UCHL-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Anti-CD45 (anti-leukocyte common antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; therefore a positive result is highly indicative of hematolymphoid origin. Certain types of hematolymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
2B11 & PD7/26
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mason, DY, Am Pathol 1987;128:1-4
References 2:
Hall PA, Histopathology 1988;13:149-160
References 3:
Kurtin, PJ, Hum Path 1985;16:353-365
References 4:
Maluf HM et al. Mod Pathol. 1995 Feb; 8(2): 155-9
References 5:
Caballero T et al. J Clin Pathol. 1995 Aug;48(8): 743-8
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