Anti-FSH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with FSH-producing cells (gonadotrophs).
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Baenziger JU, et al. Biochim Biophys Acta. 1988; 947:287-306
References 2:
Nussey SS, et al. BIOS Scientific Publishers Ltd; 2001 p. 217-79
References 3:
Uccella S, et al. Pituitary. 2000; 3:131-9
References 4:
Schmid M, et al. Pathol Res Pract. 2001; 197:663-9
Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gurley LR, et al. Eur J Biochem 1978; 84:1-15
References 2:
Hendzel MJ, et al. J Biol Chem 1998; 273:24470-8
References 3:
Colman H, et al. Am J Surg Pathol. 2006; 30:657-64
References 4:
Nasr MR, et al. Am J Dermatopathol. 2008; 30:117-22
Anti-Synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneths cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-Synaptophysin is an independent broadrange marker of neural and neuroendocrine differentiation.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Navone F, et al. J Cell Biol. 1986; 103:2511-27
References 2:
Wiedenmann B, et al. Cell. 1985; 41:1017-28
References 3:
Kayser K, et al. Pathol Res Pract. 1988; 183:412-7
Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly). It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Rezaei M, et al. J Res Med Sci. 2012; 17:681-5
References 2:
Al-Brahim NY, et al. J Clin Pathol. 2006; 59:1245-53
References 3:
Fukaya T, et al. Cancer. 1980; 45:1598-1603
References 4:
Kovacs K, et al. Virch Arch Pathol Anat. 1982; 395:59-68
The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kD or hematopoietic variant (CD44s) that is found in mesodermal cells such as hematopoietic, fibroblastic, and glial cells, as well as in some carcinoma cell lines. Higher molecular weight isoforms have been described in epithelial cells (CD44v) and are thought to function in intercellular adhesion and stromal binding. While many human tumors express CD44, a positive correlation between CD44v expression and tumor dedifferentiation has been demonstrated. MON 3237 may be useful in discrimination of urothelial carcinoma in-situ from non-neoplastic changes in the urothelium.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-13
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hudson D, et al. Int. J. Cancer. 1996; 66:457-63
References 2:
East JA, et al. Eur J Cancer. 1993; 29A:1921-2
References 3:
Gadalla HA, et al. BJU Int. 2004; 93:151-5
References 4:
McKenney JK, et al. Am J Surg Pathol. 2001; 25:1074-8
References 5:
Lopez-Beltran A, et al. Anal Quant Cytopathol Histpathol. 2013; 35:121-9
S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.1,2,6 Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly.1-4 A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue, 3 and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.4,5 Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
4C4.9
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Nakajima T, et al. Ad J Surg Path. 1982; 6:715-727
References 2:
Kuhn HJ, et al. Am J Clin Path. 1983; 79:341-347
References 3:
Yaziji H, et al. Int J Surg Pathol. 2003; 11:11-5
References 4:
Patel P, et al. J Am Acad Dermatol. 2002; 46:264-70
References 5:
Morrison CD, et al. Semin Diagn Pathol. 2000; 17:204-15
Anti-CEA specifies a group of proteins in the Carcinoembryonic Antigen (CEA) family of proteins which are present in the epithelia of various types and tumors (both benign and malignant) derived from such epithelia. Such tissues are represented by the epithelia of colon, bronchus, alveoli, breast, pancreas, biliary tract, superficial layer and parietal layers of the stomach. Predominately biliary canaliculi are labelled in the liver and this factor is useful in the diagnosis of hepatocelluar carcinoma. Anti-CEA has been quite useful in differentiating adenocarcinoma of the lung vs. mesothelioma. Associated products: CK 5/6, Calretinin, WT-1, E-Cadherin, TTF-1, TAG-72, EMA, CK 20
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Shield PW, et al. Am J Clin Pathol. 1996; 105:157-62
References 2:
Sheahan K, et al. Am J Clin Pathol. 1990; 94:157-64
hCG is a protein secreted in large quantities by normal trophoblasts; the antibody detects cells and tumors of trophoblastic origin such as Choriocarcinoma. Large Cell Carcinoma and Adenocarcinoma of Lung demonstrate hCG positivity in 90% and 60% of cases respectively. 20% of Squamous Cell Lung Carcinomas are positive for hCG. hCG expression by nontrophoblastic tumors may indicate aggressive behavior since it has been observed that hCG may play a role in the host response to a given tumor.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Helicobacter pylori is strongly associated with inflammation of the stomach and is also implicated in the development of gastric malignancy, peptic ulcers, and gastric lymphomas in humans. Helicobacter pylori can exist in a number of locations: in the mucus, attached to epithelial cells, or inside of vacuoles in epithelial cells, where it produces adhesions that bind to membrane-associated lipids and carbohydrates in or on epithelial cells. The most reliable method for detecting H. pylori infection is a biopsy during endoscopy histologic examination and detection by immunohistochemistry. Immunohistochemical staining of H. pylori on the surface of gastric mucosa is a valuable tool for identification of H. pylori infections.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Immunohistochemical staining with anti-calcitonin antibody has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Matias-Guiu X, et al. Endocr Pathol. 2014; 25:21-9
References 2:
Fisher S, et al. Arch Pathol Lab Med. 2008;132:359-72
The antibody detects surface immunoglobulin on normal and neoplastic B-cells. Anti-lambda staining is seen in B-cell follicles of human lymphoid tissue. When dealing with B-cell neoplasms, the determination of light chain ratios remains helpful. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder is very likely.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
Lamb14
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hertel, BF, et al. Lab Invest 1977;36:12
References 2:
Taylor, CL Arch Pathol Lab Med 1978;12:113-121
References 3:
Abbondanzo SL et al. Ann Diagn Pathol. 1999 Oct;3(6):394
References 4:
Kurtin PJ et al. Am J Clin Pathol. 1999 Sep;112(3):319-29
References 5:
Ashton-Key M et al. Histopathology. 1996 Dec;29(6):525-31
The antibody detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
L1C1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hertel, BF, et al. Lab Invest 1977;36:12
References 2:
Mendes S, Dreno B. Acta Derm Venereol. 2003;83(3):167-70
References 3:
Lee LA et al. Am J Otolaryngol. 2002 Sep-Oct;23(5):316-20
References 4:
Taylor, CL Arch Pathol Lab Med 1978;12:113-121
References 5:
Schmid U et al. Am J Surg Pathol. 1995 Jan;19(1):12-20
Anti-Myeloperoxidase detects granulocytes and monocytes in blood and precursors of granulocytes in the bone marrow. This antibody can detect myeloid cell populations of the bone marrow as well as in other sites.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Pinkus GS, et al. Mod Pathol. 1991; 4:733-41
References 2:
Markoc F, et al. Tumori. 2010; 96:149-53
References 3:
Alexiev BA, et al. Diagn Pathol. 2007; 31;2:42
References 4:
Saravanan L, et al. Int J Lab Hematol. 2010; 32:132-6
References 5:
Manaloor EJ, et al. Am J Clin Pathol. 2000; 113:814-22
Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases +), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma. Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
AC-1A1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Nemes Z, Hum Pathol 1992 Jul; 23(7):805-10
References 2:
Horenstein MG et al. Am J Surg Pathol. 2000 Jul;24(7):996-1003
References 3:
Kraus MD et al. Am J Dermatopathol. 2001 Apr;23(2):104-11
References 4:
Dehner LP. Am J Surg Pathol. 2003 May;27(5):579-93
References 5:
Deguchi M et al. Arch Dermatol Res. 2002 Oct;294(7):297-302
Human placental lactogen (hPL), also previously known as human chorionic somatomammotropin, is a 22-kD protein with partial homology to growth hormone. hPL is first detectable in the maternal serum in the fifth week of gestation and is involved in maintaining nutritient supply to the fetus. Anti-hPL reactivity is seen in syncytiotrophoblastic cells of placenta and choriocarcinoma
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Shih IM, et al. Am J Surg Pathol. 2004; 28:1177-83
References 2:
Ulbright TM, et al. Am J Surg Pathol. 1997; 21:282-8
Alpha-fetoprotein (AFP) is a fetal tumor-associated polypeptide of the albuminoid gene family that binds and transports molecules in addition to many other proposed functions. This secretory protein is synthesized primarily in the fetal liver whereas expression is repressed in adult liver.Anti-AFP has been immunohistochemically demonstrated in hepatocellular carcinoma (HCC) and shows no immunoreactivity in normal liver.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mizejewski GJ et al. Exp Biol Med. 2001; 226:377-408
References 2:
Lazarevich NL et al.Biochemistry (Mosc). 2000; 65:117-33
References 3:
Yusof YA, et al. Anal Quant Cytol Histol. 2003; 25:332-8
The immunohistochemical staining of Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for A-1-Antitrypsin may also be used in detection of benign and malignant lesions of an histiocytic nature. Sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain etiology.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Callea F, et al. J Hepatol. 1986; 2:389-401
References 2:
Palmer PE, et al.Am J Clin Pathol. 1974; 62:350-4
References 3:
Palmer PE, et al. Cancer. 1980; 45:1424-31
References 4:
Raintoft I, et al. Hum Pathol. 1979; 10:419-24
References 5:
Ramsay AD, et al. Appl Immunohistochem Mol Morphol. 2008; 16:140-7
Prolactin (PRL) is a single-chain polypeptide of 226 amino acids and plays a role in multiple processes including cell growth, reproduction, and immune function. Anti-Prolactin reacts with prolactin-producing cells and is a useful marker in classification of pituitary tumors and the study of pituitary disease.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Asa SL, et al. Arch Pathol Lab Med. 1982; 106:360-3
References 2:
Duello TM, et al. Am J Anat. 1980; 158:463-9
References 3:
Minniti G, et al. Surg Neurol. 2002; 57:99-103
References 4:
Popadic A, et al. Surg Neurol. 1999; 51:47-54
References 5:
Nevalainen MT, et al. J Clin Invest. 1997; 99:618-27
Immunostaining with anti-myoglobin provides a specific, sensitive, and practical procedure for the identification of tumors of muscle origin. Since myoglobin is found exclusively in skeletal and cardiac muscle and is not present in any other cells of the human body, it may be used to distinguish rhabdomyosarcoma from other soft tissue tumors.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mukai K, et al. Am J Surg Pathol. 1979; 3:373-6
References 2:
Corson JM, et al.Am J Pathol. 1981; 103:384-9
References 3:
Brooks JJ. Cancer. 1982; 50:1757-63
References 4:
Furlong MA, et al. Ann Diagn Pathol. 2001; 5:199-206
Anti-Lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages, and monocytes in human tonsil, colon and skin. It is an important marker that may demonstrate the myeloid or monocytic nature of acute leukemia. The restrictive nature of anti-lysozyme antibody staining suggests that lysozyme may be synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. Anti-lysozyme may aid in the identification of histiocytic neoplasias, large lymphocytes and classifying lymphoproliferative disorders.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Rehg J, et al. Toxicol Pathol. 2012; 40: 345-74
References 2:
Seifert RP, et al. Annals Diag Pathol. 2014; 18:253-60.
Luteinizing hormone (LH) is a heterodimeric glycoprotein produced by gonadotropic cells of the pituitary gland. Anti-LH is a useful marker to aid in the classification of pituitary tumors and the study of pituitary disease.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Sano T, et al. Virchows Arch A Pathol Anat Histopathol. 1990; 417:361-7
References 2:
Felix I, et al. Hum Pathol. 1991; 22:719-21
References 3:
Saccomanno K, et al. J Clin Endocrinol Metab. 1994; 78:1103-7
DOG1 is expressed ubiquitously in gastrointestinal stromal tumors irrespective of c-kit or PDGFR alpha mutation status. Reactivity for DOG1 may aid in the diagnosis of gastrointestinal stromal tumors, including PDGFRA mutants that fail to express c-kit antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the c-kit tyrosine kinase. Positive control Gastrointestinal stromal tumor tissue
ACTH or Adrenocorticotropic hormone is synthesized from pre-pro-opiomelanocortin (pre-POMC). ACTH is produced and secreted from corticotrophs in the anterior lobe (or adenohypophysis) of the pituitary gland. The anti-ACTH immunohistochemical reagent could be useful in the study of neoplastic and non-neoplastic pituitary diseases
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Pizarro CB, et al. Braz J Med Biol Res. 2004; 37:235-43
References 2:
Kageyama K, et al. Am J Med Sci. 2002; 324:326-30
References 3:
Fan X, et al. J Histochem Cytochem. 2002; 50:1509- 16
References 4:
Japon MA, et al. J Clin Endocrinol Metab. 2002; 87:1879-84
Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid, germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. TTF-1 labeling is also seen in thyroid and thyroid-derived tumors. TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions. TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and largecell carcinomas.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
8G7G3/1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Bejarano PA, et al. Mod Pathol. 1996; 9:445-52
References 2:
Di Loreto C, et al. Cancer Lett. 1998; 124:73-8
References 3:
Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8
References 4:
Jang KY, et al. Anal Quant Cytol Histol. 2001; 23:400-4
Tumor associated glycoprotein (TAG)-72 is a high molecular weight glycoprotein that is present on the surface of many neoplastic cells, including adenocarcinomas of the breast, colon, and lung. TAG-72 is found in lung adenocarcinoma and is absent in mesothelioma, making the TAG-72 antibody useful in distinguishing adenocarcinoma from mesothelioma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
B72.3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Thor, A, et al. Cancer Res 1986;46:3118
References 2:
Schlom J, et al. Tumormarker Oncology;1987;2:3
References 3:
Osteen KG et al. In J Gynecol Pathol. 1992 Jul;11(3):216-20
References 4:
Ordonez NG. Am J Surg Pathol. 1998 Oct;22(10):1203-14
References 5:
Chhieng DC et al. Hum Pathol. 2003 Oct;34(10):1016-21
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.
