Human germinal center associated lymphoma (HGAL) protein is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the interfollicular and paracortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. Anti-HGAL has the highest overall sensitivity of detecting follicular lymphoma (FL) and in detecting the interfollicular and diffuse components of FL compared with antibodies against bcl2, LMO2, CD10, and bcl6. The addition of anti-HGAL to the immunohistologic panel is beneficial in the work-up of nodal and extranodal B-cell lymphomas, and the efficacy of anti-HGAL in detecting the follicular, interfollicular, and diffuse components of FL is of particular value in the setting of variant immunoarchitectural patterns
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-49
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Natkunam Y, et al. Blood. 2005; 105:397986
References 2:
Natkunam Y, et al. Blood. 2007; 109:298-305
References 3:
Younes SF, et al. Am J Surg Pathol. 2010; 34:1266-76
References 4:
Higgins RA, et al. Arch Pathol Lab Med. 2008; 132:441-6
Neuron-specific enolase (NSE) is the glycolytic isoenzyme of the enolase gamma-gamma dimer specifically detected in neurons of neuroendocrine cells, and their corresponding tumors. In addition, NSE has been demonstrated immunohistochemically in the non-neoplastic cells of the pituitary, peptide secreting tissues, pineolocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. Anti-NSE immunostaining is also positive in normal striated muscle, hepatocytes and, to a lesser extent, smooth muscle. Anti-NSE is a useful marker to identify peripheral nerves.5 When used for the identification of neuroendocrine differentiation, it is suggested that it be employed in a panel with more specific markers such as anti-synaptophysin, anti-chromogranin, and anti-neurofilament.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-55
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wick MR, et al. Am J Clin Pathol. 1983; 79:703-7
References 2:
Vinores SA, et al. Arch Pathol Lab Med. 1984; 108:536-40
CD11c is an adhesion receptor of the leukocyte function-associated family of molecules. Reportedly CD11c is expressed in hairy cell leukemia whereas the majority of other small B-cell lymphomas do not express CD11c antigen. This indicates that immunohistochemical staining of formalin-fixed biopsies with anti-CD11c can be useful for identification of hairy cell leukemia.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
5D11
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Korinna, J et al. Pathobiology 2008; 75:252256
References 2:
Jones, G et al. Br J Hemaetol 2011; 156:186-195
References 3:
Went, PT et al. Am J Surg Pathol 2005; 29:474478
References 4:
Miranda, RN et al. Modern Pathology 2000; 13:13081314
CD33, also known as gp67 or SIGLEC-3, is a 67 kDa glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. Although the precise physiological function of CD33 is unknown, it may mediate cell to cell adhesion and modulate inflammatory and immune response. In normal tissue, anti-CD33 labels myeloid cells (especially myeloid precursors), liver Kupffer cells, lung alveolar macrophages, and placental syncytiotrophoblasts. In neoplastic tissue, anti-CD33 is useful for the identification of acute myeloid leukemia.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
PWS44
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Freeman SD, et al. Blood. 1995; 85:2005-12
References 2:
Laszlo GS, et al. Oncotarget. 2016; 7:43281-94
References 3:
Crocker, PR et al. Biochem Soc Symp 2002; 69:83-96
S100P is a member of the S100 family of proteins. The family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. Anti-S100P with nuclear or nuclear/cytoplasmic immunoreactivity can be seen in pancreatic ductal adenocarcinomas, while it is rarely detectable in benign pancreatic ducts. It may also help to distinguish urothelial carcinomas from other genitourinary neoplasms such as prostate carcinoma
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
16/f5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Lin F, et al. Am J Surg Pathol 2008; 32:78-91
References 2:
Deng HB. Am J Clin Pathol 2008; 129:81-8
References 3:
Nakata K et al. Hum Pathol 2010; 41:824-31
References 4:
Higgins JP, et al. Am J Surg Pathol 2007; 31:673-80
T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. TCL1 is expressed in differentiated Bcells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. The Anti-TCL1 immunohistochemical reactivity is reportedly useful identifying B-cell lymphomas including follicular lymphoma and Burkitt lymphoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-7
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Takizawa J, et al. Jpn J Cancer Res. 1998; 89:712-8
References 2:
Narducci MG, et al. Cancer Res. 2000; 60:2095-100
References 3:
Rodig SJ, et al. Am J Surg Pathol. 2008; 32:113-22
References 4:
Herling M, et al. Leukemia. 2006; 20:280-5
References 5:
Pescarmona E, et al. Histopathology. 2006; 49:343-8
Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.1,2 To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors.3-5 Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
R4A
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
van der Loop FT, et al. J Cell Biol. 1996; 134:401-11
References 2:
Maake C, et al. J Urol. 2006; 175:1152-7
References 3:
Paner GP, et al. Am J Surg Pathol. 2010; 34:792-9
References 4:
Council L, et al. Mod Pathol. 2009; 22:639-50
References 5:
Coco DP, et al. Am J Surg Pathol. 2009; 33:1795-801
CD2 is a surface antigen present on all peripheral T-cell lymphocytes. CD2 is associated with signaling and mediating adhesion to other T-cells through the lymphocyte function-associated antigen and CD48/BCM1 complex. MON 3225 is a useful immunohistochemical reagent for identification of normal T-lymphocytes, and for assessing lymphoid malignancies.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-11
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Aguilera NS, et al. Arch Pathol Lab Med. 2006; 130:1772-9
References 2:
Barrionuevo C, et al. Appl Immunohistochem Mol Morphol. 2007; 15:38-44
References 3:
Bovenschen HJ, et al. Br J Dermatol. 2005; 153:72-8
References 4:
Foon KA, et al. Blood. 1986; 68:1-31
References 5:
Gonzalez L, et al. Journal of Comparative Pathology 2001; 125:41-7
CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. MON 3028 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas. Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers. Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP3093
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Dillon KM et al. J Clin Pathol. 2002 Oct;55(10):791-4
CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/ macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-57
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells. Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes. Therefore, anti-CD71 is a useful marker for highlighting erythroid precursors in bone marrow specimens. Increased CD71 expression is also associated with active cell growth including neoplastic tumor growth and may be seen in various carcinomas such as thyroid carcinomas, lung carcinomas, breast carcinomas, hepatocellular carcinomas and colorectal carcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-48
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ponka P, et al. Int J Biochem Cell Biol. 1999; 31:1111-1137
References 2:
Sieff C, et al. Blood. 1982; 60:703-713
References 3:
Lesley J, et al. Cell Immunol.1984; 83:14-25
References 4:
Nakahata T, et al. Leuk Lymphoma. 1994; 13:401-409
References 5:
Marsee DK, et al. Am J Clin Pathology. 2010; 13:429-435
CD99, as detected with a variety of antibodies, is expressed by virtually almost all Ewings sarcoma and primitive peripheral neuroectodermal tumors (ES/PNET) and demonstrates strong and diffuse membranous staining. Other tumors that may show CD99 expression include neuroendocrine carcinomas, mesenchymal chondrosarcomas, solitary fibrous tumors, synovial sarcomas, vascular tumors, small round blue cell tumors, lymphoblastic lymphoma, acute myeloid leukemia, and myeloid sarcoma.5 However, strong and diffuse membranous reactivity for CD99 favors ES/PNET over the other diagnostic considerations. The other CD99+ tumors usually show cytoplasmic and more heterogeneous staining. Therefore, when making a final diagnostic interpretation, CD99 must be considered in a panel with other antibodies.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EPR3097Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Rettig WJ, et al. Lab Invest. 1992; 66:133
References 2:
Fellinger EJ, et al. Amer J Surg Pathol. 1992; 16:746
References 3:
Ambros IM, et al. Cancer. 1991; 139:317
References 4:
Khoury JD. Adv Anat Pathol. 2005; 12:212-20
References 5:
Dabbs DJ. Theranostic and Genomic Applications. 2014; 126
Blood group Lewis carbohydrate determinants are oligosaccharides on glycolipids and glycoproteins. In healthy individuals the LewisY antigen is a type 2 antigen usually only expressed in low levels of a few cell types such as some epithelial cells. Reportedly these antigens are aberrantly expressed in high levels in many carcinomas. Anti-BG8, LewisY reactivity in immunohistochemistry is seen in carcinomas of the breast, lung, and colon
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
F3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Davidson B, et al. Virchows Arch. 1999; 435:43-9
References 2:
King JE, et al. Histopathology. 2006; 48:223-32
References 3:
Marchevsky AM et al. Appl Immunohistochem Mol Morphol. 2007; 15:140-4
Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases +), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma. Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP3372
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Nemes Z, Hum Pathol 1992 Jul; 23(7):805-10
References 2:
Horenstein MG et al. Am J Surg Pathol. 2000 Jul;24(7):996-1003
References 3:
Kraus MD et al. Am J Dermatopathol. 2001 Apr;23(2):104-11
References 4:
Abenoza P, et al. Am J Dermatopathol. 1993; 15:429-34
References 5:
Anstey A, Cerio R, et al.: Am J Dermatopathol 1994 Feb: 16(1):14-22
GCDFP-15 is a glycoprotein localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, ear canal, and in salivary glands. GCDFP-15 positivity is seen in breast carcinomas. On the other hand, colorectal carcinomas, lung carcinoma, mesotheliomas rarely stain with this antibody. Because of its specificity for breast carcinoma, this antibody is often helpful in distinguishing metastasis of unknown primary.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP1582Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mazoujian G, et al. Am J Pathol. 1983; 110:105-12
References 2:
Liegl B, et al. Histopathology. 2007; 50:439-47
References 3:
Bhargava R, et al. Am J Clin Pathol. 2007; 127:103-13
References 4:
Tornos C, et al. Am J Surg Pathol. 2005; 29:1482-9
References 5:
Takeda Y, et al. Arch Pathol Lab Med. 2008; 132:239-43
Mi is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
C5/D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Liegl B, et al. Am J Surg Pathol. 2008; 32:608-14
References 2:
Righi A, et al. Int J Surg Pathol. 2008; 16:16-20
References 3:
Weinreb I, et al.. Virchows Arch. 2007; 450:463-70
References 4:
Ohsie SJ, et al. J Cutan Pathol. 2008; 35:433-44
References 5:
Hornick JL, et al. Am J Surg Pathol. 2008; 32:493-501
Anti-Cytokeratin (OSCAR) is well suited to distinguish epithelial carcino¬ma from non-epithelial malignancies and is used to aid epithelial tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin containing cells in epithelia during normal development and during the develop¬ment of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in recognizing epithelial cells, and carcinomas.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
OSCAR
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gown, AM, et al. Am J Clin Pathol 1985;84:413
References 2:
Battifora, H. Am J Surg Pathol 1988;12:24
References 3:
Lewis JE et al. Hum Pathol. 1997 Jun;28(6):664-73
References 4:
Mueller JD et al. Cancer. 2000 Nov 1;89(9):1874-82
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and, despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing.Various lymphomas are also positive for this marker including the following: Bchronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and classic Hodgkin lymphoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Browne P, et al. Am J Clin Pathol. 2003; 120:767-77
References 2:
García-Cosío M, et al. Mod Pathol. 2004; 17:1531-8
References 3:
Gibson SE, et al. Am J Clin Pathol. 2006; 126:916-24
The antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-40
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wiedenmann, B, et al. Cell 1985;41:1017-1028
References 2:
Navone, F et al. J Cell Biol 1986;103:2511-2527
References 3:
Lyda MH et al. Hum Pathol. 2000 Aug;31(8):980-7
References 4:
Skacel M et al. Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):302-9
Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD) with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin. Antithrombomodulin has demonstrated positivity in benign vascular tumors such as hemangioma and most malignant vascular tumors (Kaposis sarcoma and epitheliod hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of antithrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas. Anti-thrombomodulin is immunoexpressed in a variety of other tumors including urothelial cell carcinomas
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
1009
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Acebo E, et al. Histol. Histopath. 2001; 16:1031-6
References 2:
Appleton MA, et al. Histopathology. 1996; 29:153-7
References 3:
Attanoos RL, et al. Histopathology. 1996; 29:209-15
References 4:
Attanoos RL, et al. Histopathology. 2001; 39:584-8
Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A (NAPSA) and napsin B (NAPSB). Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung.4 In normal tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney. Napsin A is a useful marker for lung adenocarcinoma
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Brasch F, et al. J Biol Chem. 2003; 278: 49006-14
References 2:
Jagirdar J et al. Arch Pathol Lab Med. 2008; 132:384-96
References 3:
Bishop JA, et al. Hum Pathol. 2010; 41:20-5
References 4:
Ye J, et al. Appl Immunohistochem Mol Morphol. 2011; 19:313-17
References 5:
Mukhopadhyay S, et al. Am J Surg Pathol. 2011; 35:15-25
Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A (NAPSA) and napsin B (NAPSB). Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung. In normal tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney. Napsin A is a useful marker for lung adenocarcinoma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-60
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jagirdar J. Arch Pathol Lab Med.; 132:384-96 (2008)
References 2:
Bishop JA, et al.. Hum Pathol.; 41:20-5 (2010)
References 3:
Ye J, et al. Appl Immunohistochem Mol Morphol.; 19:313-17 (2011)
References 4:
Mukhopadhyay S, et al. Am J Surg Pathol.; 35:15-25 (2011)
References 5:
Rawlings ND and Salvesen GS. Academic Press.; p.69-71 (2013)
Transcription factor E3 (TFE3) is a protein expressed in many cell types that are encoded by the TFE3 gene. This gene may be involved in chromosomal translocations that occur in some cancers.Xp11 translocation renal cell carcinomas (RCC) are a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus.1 Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma of uncertain differentiation. The hallmark of ASPS is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an ASPSCR1-TFE3 fusion gene responsible for an aberrant transcription factor presumably enabling pathogenesis.1-5
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-37
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Argani P. Am J Clin Pathol. 2006; 126:332-4
References 2:
Argani P, et al. Am J SurgPathol. 2003; 27:750-61
References 3:
Argani P, et al. Clin Lab Med.2005; 25:363-78
References 4:
Lazar AJ, et al. Histopathol. 2009; 55:750-5
References 5:
Lin G, et al. Arch Pathol Lab Med. 2015; 139:106-21
Glucose transporter type I (GLUT1), a prototype member of GLUT super family, reacts with a 55 kD protein, is a membrane-associated erythrocyte glucose transport protein. It is a major glucose transporter in the mammalian blood-brain barrier, and also mediates glucose transport in endothelial cells of the vasculature, adipose tissue and cardiac muscle. GLUT1 is detectable in many human tissues including those of colon, lung, stomach, esophagus, and breast. GLUT1 is overexpressed in malignant cells and in a variety of tumors that include the breast, pancreas, cervix, endometrium, lung, mesothelium, colon, bladder, thyroid, bone, soft tissues, and oral cavity. Immuohistochemical detection of GLUT1 can discriminate between reactive mesothelium and malignant mesothelioma. Anti-GLUT1 with anti-Claudin1, and anti-EMA are perineurial markers in diagnosis of perineuriomas. Anti-GLUT1 is also useful in distinguishing benign endometrial hyperplasia from atypical endometrial hyperplasia and adenocarcinoma. GLUT1 expression has been associated with increased malignant potential, invasiveness, and a poor prognosis in general. Expression of GLUT1 is a late event in colorectal cancer and expression in a high proportion of cancer cells is associated with a high incidence of lymph node metastases.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kato Y, et al. Mod Pathol. 2006; 20:215-20
References 2:
Afify A, et al. Acta Cytol. 2005; 49:621-6
References 3:
Parente P, et al. J Exp Clin Cancer Res. 2008; 27:34
References 4:
Zimmerman RL, et al. Cancer. 2002; 96:53-7
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.
