Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes.Clone KM51 is specific for alpha-synuclein and is unreactive with beta-synuclein. Pretreatment of tissue sections with 98-100% formic acid is also recommended.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
KM51
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Baba M et al. American Journal of Pathology. 152 (4): 879884 (1998)
References 2:
Polymeropoulos MH et al. Science. 276: 20452047 (1997)
References 3:
Spillantini MG et al. Nature. 388: 839840 (1997)
References 4:
Weinreb PH et al. Biochemistry. 35 (43): 1370913715 (1996)
NCL-CK5/6/8/18, NCL-L-CK5/6/8/18 and RTU-CK5/6/8/18 react with human cytokeratins 5, 6, 8 and 18. These products are cocktails of monoclonal antibodies designed to recognize cytokeratins reported to be expressed in almost all epithelial tissues.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5D3/LP34
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mMsodium azide
Storage:
2-8°C
References 1:
Hatzfeld M and Weber K. Journal of Cell Biology. 116: 157166 (1992)
References 2:
Angus B et al. Journal of Pathology. 155: 7175 (1988)
References 3:
Ghosh A K et al. British Journal of Haematology. 61: 2130 (1985)
References 4:
Gatter KC et al. Journal of Clinical Pathology. 35: 12531267 (1982)
Clones AE1 and AE3 are specific for the 56.5, 50, 50', 48 and 40 kD acidic cytokeratins as well as the 65 to 67, 64, 59, 58, 56 and 52 kD basic cytokeratins. The cocktail of clones AE1 and AE3 exhibit broad reactivity with two families of cytokeratin, acidic and basic.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
AE1/AE3
Concentration:
Greater than or equal to 225 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Nadji M, Morales AR. Laboratory Medicine. 1983; 14:767
References 2:
Omata M et al. Am.J.of Clin. Pathol. 1980; 73:626
References 3:
Su T et al. Diagnostic Pathology. 2014; 9: 179
References 4:
Zhao W et al. Int.J. of Clin. and Exp.Pathol. 2014; 7(11): 7951-7956
References 5:
Hammers HJ et al. Molecular Cancer Therapeutics. 2010; 9(6): 1525-1535
Cytokeratins 5, 6 and 18 are reported to be expressed in a broad range of human epithelial tissues, from simple glandular epithelia to stratified squamous epithelia. These include epithelial cells that are ectodermal, mesodermal, or endodermal in origin. These cytokeratins have been reported to be expressed in tumor cells of epithelial origin and less commonly of mesothelial origin. Non-epithelial tumors such as lymphomas do not express these cytokeratins. The recognition of cytokeratin 18 on formalin fixed paraffin embedded sections using clone LP34 may be variable.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
LP34
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Lyall F et al. The American Journal of Pathology. 2001;159(5):1827-1838
References 2:
Yokozaki H et al. Japanese Journal of Clinical Oncology. 2000;30(2):101-104
References 3:
Lyall F et al. The American Journal of Pathology. 1999;154(4):1105-1114
Clone 5D3 reacts with human cytokeratin intermediate filament proteins of 52.5 kD and 45 kD, identified as cytokeratins 8 and 18, respectively. Clone 5D3 shares similar specificities to clone CAM5.2 (Angus B et al. Journal of Pathology. 153: 377-384 (1987)).
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5D3
Concentration:
Greater than or equal to 420 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Nadji M, Morales AR. Laboratory Medicine. 1983; 14:767
References 2:
Omata M et al. Am.J.of Clin. Pathol. 1980; 73:626
References 3:
Angus B et al. J.of Pathology. 1988; 155(1):7175
References 4:
Martin CA et al. Appl Immunohistochem Mol Morphol. 2001; 9(1):7073
References 5:
Mehes G et al. Am. J.of Pathol. 2001; 159(1):1720
Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.
Antibody Isotype:
IgG2a, kappa
Monosan Range:
MONXtra
Clone:
Ks20.8
Concentration:
Greater than or equal to 9,26 mg/L
Storage buffer:
PBS (pH 7.6) with 1% BSA and sodium azide
Storage:
2-8°C
References 1:
Botta MC et al. Pathologica. 2001; 93(6):640-644
References 2:
Leech SN et al. Journal of Clinical Pathology. 2001; 54:727-729
References 3:
Tan J et al. Human Pathology. 1998; 29(4):390-396
References 4:
Longatto Filho A et al. Acta Cytol. 1997; 41(4):961-971
References 5:
Moll R et al. American Journal of Pathology. 1992; 140(2):427-447
Cytokeratins 14 and 5 are useful to distinguish stratified epithelial cell types from simple epithelial cell types. Cytokeratin 14 has been reported to be expressed in neoplasms of squamous cell origin.Clone LL002 reacts with the human cytokeratin intermediate filament protein (50 kD) identified as cytokeratin 14.
Antibody Isotype:
IgG3
Monosan Range:
MONXtra
Clone:
LL002
Concentration:
Greater than or equal to 24 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Reis-Filho JS et al. Journal of Clinical Pathology. 2004; 57:83-86
References 2:
Sivard P et al. Experimental Dermatology. 2003; 12(4):346355
References 3:
Fong LYY et al. Cancer Research. 2003; 63:186195
References 4:
Nagao T et al. Histopathology. 2001; 38(1):3036
References 5:
Nakayama H et al. Japanese Journal of Clinical Oncology. 1997; 27(6):427432
Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokeratins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
OV-TL 12/30
Concentration:
Greater than or equal to 67 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
van de Molengraft FJJM et al.Histopathology. 1993; 22:35-38
References 2:
van Niekerk CC et al. Journal of Pathology. 1991; 165(2):145-15
Cytokeratins are a large family of cytoskeletal proteins found in epithelial cells. They are co-ordinately synthesized in pairs so that at least one member of each family is expressed in each epithelial cell. Cytokeratins assemble into obligatory heteropolymers composed of type I (acidic) and type II (basic) polypeptides to form higher order tetramers and protofilaments. Basal cells of human epidermis express acidic keratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kD protein that is closely related to cytokeratin 6. Point mutations in the cytokeratin 5 gene at locus 12q11-q13 can cause various types of epidermolysis bullosa simplex. Cytokeratin 5 is also reported to be expressed in most epithelial and biphasic mesotheliomas. Clone XM26 is specific for the 58 kD intermediate filament protein known as cytokeratin 5. It is not cross-reactive with cytokeratin 6.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
XM26
Concentration:
Greater than or equal to 21 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Bhargava R et al. The American Journal of Clinical Pathology . 2008; 130:724-730
References 2:
Laakso M e al. Clinical Cancer Research. 2006; 12(14):4185-4191
References 3:
Miettinen M et al. American Journal of Surgical Pathology. 2003; 27(2):150158
References 4:
Zhang RR et al. Breast Cancer Research. 2003; 5:R151R156
DES-DERII reacts with an 18 kD rod piece of the intermediate filament protein desmin (53 kD) in muscle cells. The antibody does not appear to recognize other intermediate filament proteins. In normal tissues, Clone DE-R-11 reacts with both striated (skeletal and cardiac) and smooth muscle cells. The labeling is confined to the Z bands in skeletal and cardiac muscle giving a characteristic striated appearance.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
DE-R-11
Concentration:
Greater than or equal to 27 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Beaton LJ et al. Journal of Physiology. 2002; 544(Pt3):849-859
References 2:
Barber A et al.The FASEB Journal. 2001; 15:1158-1168
References 3:
Debus E et al.The EMBO Journal. 1983; 2(12):2305-2312
References 4:
Baghdiguian S et al. Nature Medicine. 1999; 5(5):503-511
References 5:
Lyall F et al. American Journal of Pathology. 2001; 159(5):1827-1838
Cytoplasmic actins are part of the microfilament system of cytoskeletal proteins. Smooth muscle actin is found in vascular walls, intestinal muscularis mucosae and muscularis propria and in the stroma of various tissues. Enzyme pretreatment may enhance staining in some cases. Human alpha smooth muscle actin. Reactive with smooth muscle cells in blood vessel walls, gut wall, myometrium and arrectores pili of skin. Myoepithelial cells such as those in breast and salivary gland also contain actin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
alpha sm-1
Concentration:
Greater than or equal to 4,5 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Skalli O et al. The Journal of Cell Biology. 1986; 103:2787-2796
References 2:
Ramos JG et al. Endocrinology. 2003; 144(7):3206-3215
References 3:
Suárez-Vilela D and Izquierdo-Garcia FM. Histopathology. 2003; 43(4):398-400
References 4:
Vicario JH et al. Rev Fed Arg Cardiol. 2002; 31:441-449
References 5:
Barry-Lane PA et al. Journal of Clinical Investigation. 2001; 108(10):1513-1522
Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase of 58 kD located in the cell nucleus which catalyzes the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is reported to be expressed in primitive T and B lymphocytes of the normal thymus and bone marrow. The identification of TdT-positive cell populations in primary and secondary lymphoid organs during maturation of the immune system is one area of interest but it is the reported occurrence of high levels of enzyme activity in white blood cells and bone marrow in certain leukemias which is of particular interest.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
SEN28
Concentration:
Greater than or equal to 30 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Tai YC and Peh SC. FSingapore Medical Journal. 2003; 44(5):250-255
Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520??).
Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5A4
Concentration:
Greater than or equal to 32 mg/L
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Liu A et al. Acta Histochemica et Cytochemica. 2004; 37(1):21-30
Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
11F1
Concentration:
Greater than or equal to 47 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Lee HK et al. J Korean Med Sci. 2003; 18:272276
References 2:
Theate I et al.European Journal of Haematology. 2002; 69(4):248253
Human von Willebrand factor (or factor VIII-related antigen) is a 270 kD multimeric plasma glycoprotein. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein Ib/IIIa, collagen and heparin. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
36B11
Concentration:
Greater than or equal to 21 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Zhang Y et al. Human Pathology. 2005; 36:797-805
References 2:
Su H et al. Proceedings of the National Academy of Sciences, USA. 2000; 97(25):13801-13806
The biosynthesis of melanin in melanocytes involves a family of enzymes, a key member of which is tyrosinase. Tyrosinase deficiency is associated with various forms of albinism and in particular oculocutaneous albinism. L-tyrosinase is the initial substrate for melanin biosynthesis and its conversion to dopaquinone is catalyzed by tyrosinase, whose expression is reported in melanocytes and melanomas.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
T311
Concentration:
Greater than or equal to 89 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Shidham VB et al. BMC Cancer. 2003; 3(1):15
References 2:
Lohmann CM et al. American Journal of Surgical Pathology. 2002; 26(10):13511357
References 3:
Clarkson KS et al. Journal of Clinical Pathology. 2001; 54(3):196200
References 4:
de Vries TJ et al. Journal of Pathology. 2001; 193(1):1320
References 5:
Jungbluth AA et al. Pathol Res Pract. 2000; 196(4):235242
Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
SPT24
Concentration:
Greater than or equal to 108 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Unal B et al. Turkish Journal of Pathology. 2014; 30(3): 201-205
References 2:
Klingen TA et al. Diagnostic Pathology. 2013; 8: 80-86
References 3:
Berghmans T et al. Lung Cancer. 2006; 52(2): 219-224
References 4:
Penman D et al. Journal of Clinical Pathology. 2006; 59:663-664.
References 5:
Comperat E et al. Modern Pathology. 2005; 18(10):1371-1376
Prostatic acid phosphatase (PAP) is an isoenzyme of acid phosphatase found in large amounts in the prostate and seminal fluid. The precise function of PAP is unknown, but it may act as a hydrolase to split phosphoryl choline in semen and also function as a transferase. Elevated serum levels of the enzyme are reported in metastatic prostatic carcinoma.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
PASE/4LJ
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Haines AMR et al. British Journal of Cancer. 60: 887892 (1989)
References 2:
Haines AMR et al. Biochemical Society Transactions. 15: 11791180 (1987)
Prostate specific antigen (PSA) is a 34 kD protein belonging to the kallikrein family of serine proteases and was originally isolated and purified from human seminal plasma. It was found to be immunologically identical and biologically similar to a protein isolated from the prostate gland. PSA is distinct from prostatic acid phosphatase. Low levels of expression of PSA have been reported in non-prostatic tissues and tumors such as breast carcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
35H9
Concentration:
Greater than or equal to 43 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Watt KWK et al. Proceedings of the National Academy of Sciences USA. 1986; 83:3166-3170
Placental alkaline phosphatase (PLAP) is a membrane-associated sialoglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. This high degree of homology between PLAP and PLAP-like enzyme together with cross-reacting antibodies has led to some confusion of the distribution of PLAP and PLAP-like enzyme in various tissues. PLAP is reported to be expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. PLAP expression is rare in malignant germ cell tumors. PLAP-like enzyme is reported to be predominantly found in normal fetal and neonatal testis, and in thymus. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
8A9
Concentration:
Greater than or equal to 26 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Bartkova J et al. Oncogene. 2000; 19: 4146-4150
References 2:
Franke FE et al. Human Pathology 2000; 31(12), 14661476
References 3:
Hoei-Hansen CE et al. Molecular Cancer. 2007; 6:12
References 4:
McCann-Crosby B et al. International Journal of Pediatric Endocrinology 2015; 1:14
Rhabdomyosarcomas are a class of myoblast-derived soft tissue sarcomas that usually express a number of muscle-specific genes and primarily affect children and young adults. Differentiation of myogenic cells is controlled by a set of regulatory genes including MyoD1, myogenin, Myf-5 and Myf-6. Myf-4 is the human homolog of myogenin. Its gene product, together with that of Myf-3, accumulates in the nucleus of differentiated cells.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
LO26
Concentration:
Greater than or equal to 13 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Den Bakker MA et al. Histopathology. 2003; 43(3):297299
References 2:
Ingeholm P et al. APMIS. 2002; 110(9):639645
References 3:
Kumar S et al. Modern Pathology. 2000; 13(9):988993
References 4:
Gilpin BJ et al. Journal of Biological Chemistry. 1998; 273(1):157166
Microphthalmia transcription factor (MITF) gene product, a nuclear transcription factor of the basic-helix-loop-helix type, is thought to play a role in the regulation of genes encoding the enzymes necessary for melanogenesis. These include tyrosinase, TRP-1 and TRP-2. MITF is critical for the embryonic development and postnatal viability of melanocytes. The melanocyte-specific isoform of microphthalmia transcription factor MITF-M, is reported to be expressed in normal and malignant melanocytes. The other isoforms, MITF-A, MITF-C and MITF-H, differ structurally at the N-terminus from MITF-M.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
34CA5
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM Sodium azide
Storage:
2-8°C
References 1:
Fang D and Setaluri V. Biochem. and Biophys. Research Comm. 256 (3): 657663 (1999)
References 2:
King R et al. American Journal of Pathology. 155 (3): 731738 (1999)
References 3:
Amae S et al. Biochem.and Biophys.Research Comm. 247: 710715 (1998)
References 4:
Watanabe A et al. Nature Genetics. 18: 283286 (1998)
Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule.
Mesothelin is a glycosyl-phosphatidylinositol-linked (GPI) glycoprotein of 40kD present on the surface of mesothelial cells, mesotheliomas, epithelial ovarian cancers and some squamous cell carcinomas. It is synthesized as a 69 kD precursor which is enzymatically processed into an N-terminal secreted form of 30 kD and the GPI-linked membrane-bound form of 40 kD. The secreted form is identical to the megakaryocyte potentiating factor, but it is the GPI-linked membrane-bound form which has generated interest. Mesothelin is abundantly expressed in the kidney and in occasional epithelial cells of the trachea, tonsil and fallopian tube. The function of mesothelin is unclear but it may have a role in cellular adhesion. Mesothelin is reported to be abundant in the normal mesothelial cells from which malignant mesotheliomas and ovarian cystadenocarcinomas are derived.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5B2
Concentration:
Greater than or equal to 40 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Ordonez NG. American Journal of Surgical Pathology. 2003; 27(11):14181428
References 2:
Ordonez NG. Modern Pathology. 2003; 16(3):192197
References 3:
Argani P et al. Clinical Cancer Research. 2001; 7(12):38623868
Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
A103
Concentration:
Greater than or equal to 22 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Shidham VB et al. BioMed Central cancer. 2003; 3(1):15
References 2:
Clarkson KS et al. Journal of Clinical Pathology. 2001; 54:196200
References 3:
De Vries TJ et al. Journal of Pathology. 2001; 193:1320
References 4:
Fang D et al. American Journal of Pathology. 2001; 158(6):21072115
References 5:
Chen YT et al. Proceedings of the National Academy of Sciences USA. 1996; 93:59155919
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