Analyte Specific Reagent. Analytical and performance characteristics are not established. The product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
Ham3/17B2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Lyophilized tissue culture supernatant containing 15 mM sodium azide. Reconstitute with the volume of sterile distilled water indicated on the vial label.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
13H6
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Blake DJ et al. Physiological Reviews. 82 (2): 291329 (2002)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
34C5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Blake DJ et al. Physiological Reviews. 82 (2): 291329 (2002)
References 2:
Oliveira AS et al. Arq Neuropsiquiatr. 50 (4): 478485 (1992
References 3:
Haginoya K et al. Journal of Neurology. 238 (7): 375378 (1991)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the carboxy terminus (between amino acids 3669 and 3685) of human dystrophin. Also crosssreacts strongly with skeletal, cardiac and smooth muscle dystrophin from normal mouse, rat, rabbit, dog, chicken and hamster. No crossreactivity with mdx mouse tissue. Crossreacts very weakly with pig dystrophin.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
DY8/6C5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the amino terminal domain (between amino acids 321 and 494) of human dystrophin. Patient immunoreactivity indicates epitope is near exons 10 to 12. Epitope mapping suggests that sequences from amino acids 308 to 351 are involved in antibody binding. This region spans the junction of exons 9 and 10 and the epitope recognised may be part of a hinge region joining the amino domain to the central rod domain. No reactivity with DMD/BMD patients deleted for exons 10 to 12. No crossreaction is observed with mouse (high background only), rat, rabbit, dog, chicken, hamster and pig dystrophin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
DY10/12B2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the rod domain (between amino acids 1181 and 1388) of human dystrophin. Also reacts with skeletal, cardiac and smooth muscle dystrophin from normal mouse, rat, rabbit, dog, hamster and pig. No reactivity with mdx mouse tissue of DMD/BMD patients who have a gene deletion which removes the antibody binding site. No reaction is seen with chicken dystrophin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
Dy4/6D3
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
36B5
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Elston MS et al. J.of Clin.Endocrinology and Metabolism. 2009; 94(4):1436-1442.
References 2:
Munhoz NG et al. The Open Pathology Journal. 2009; 3:10-17
References 3:
Chetty R and Serra S. Histopathology 2008; 52: 325330
References 4:
Schott M et al. Endocrinology and Metabolism 2007; 92(9):3378- 3382
References 5:
Dansranjavin T et al. Oncology Reports. 2006; 15:1125-1131
Analyte Specific Reagent. Analytical and performance characteristics are not established. NCL-EMERIN is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
4G5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Muschen M et al. Cancer Research. 61 (5): 20802084 (2001)
References 2:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
EGFR.113
Concentration:
Greater than or equal to 26 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Lodge AJ et al. Journal of Clinical Pathology. 2003; 56(4):300304
References 2:
Sriplakich S et al. BJU Int. 1999; 83(4):498503
References 3:
Inoue K et al. Acta Med Okayama 1998; 52(6):305310
References 4:
Tungekar MF and Linehan J. Journal of Clinical Pathology. 1998; 51:583587
Epithelial membrane antigen (EMA), also known as episialin, is reported to be expressed in a variety of normal and neoplastic epithelia. It has been reported that markers to CD45 (LCA) when used in conjunction with markers to EMA are useful in labeling cells of lymphoid origin, whereas the combination of anti-cytokeratin antibodies together with EMA is useful to characterize cells of epithelial origin. EMA is also notably described to be expressed in a subset of Hodgkin's lymphomas.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
GP1.4
Concentration:
Greater than or equal to 11 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Kim JH et al. The Korean Journal of Pathology. 2002; 36:6669
References 2:
Kim GY et al. The Korean Journal of Pathology. 2002; 36:5154
References 3:
Kojima M et al. Modern Pathology. 2002; 15(7):750758
References 4:
Yokozaki H et al. Japanese Journal of Clinical Oncology. 2000; 30:101104
Estrogen receptor (ER) content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. The introduction of highly specific monoclonal antibodies to ER has allowed the determination of receptor status of breast tumors to be carried out in routine histopathology laboratories.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
6F11
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Bevitt DJ et al. Journal of Pathology 1997; 183(2), 228232
References 2:
Kaplan, PA et al. Am J Clin Pathol 2005: 276280
References 3:
Zafrani B et al. Histopathology 2000; 37(6), 536545
References 4:
Harvey JM et al. Journal of Clinical Oncology 1999; 17(5), 14741481
References 5:
Khan SA et al.European Journal of Cancer 2000; 36(Suppl 4), S27S28
Polycomb-group proteins (PcG) such as EZH2 (Enhancer of Zeste Homolog 2 (Drosophila)) form multimeric gene repressing complexes involved in axial patterning, hematopoiesis and cell cycle regulation. PcG proteins ensure correct embryonic development by expressing homeobox genes as well as contributing to the regulation of lymphopoiesis.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
6A10
Concentration:
Greater than or equal to 20 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Van Kemenade FJ et al. Blood, 97(12): 38963901 (2001)
References 2:
Raaphorst Fm et al.American Journal of Pathology, 157(3): 709715 (2000)
References 3:
Kattan M. Journal of the National Cancer Institute. 95(9): 634635 (2003)
Human fascin is a 55 to 58 kD actin-bundling protein, whose actin binding ability is regulated by phosphorylation. In normal tissues the detection of fascin is reported to be predominantly restricted to dendritic cells, and in the thymus has been observed only in medullary dendritic cells. In reactive nodes, interdigitating reticulum cells of T cell zones, cells in subcapsular areas, and cells of the reticular network express fascin. Variable expression is seen in follicular dendritic cells and endothelial cells. Lymphoid cells, myeloid cells and plasma cells do not express fascin; however, in cases of Hodgkin's disease, including nodular sclerosis, mixed cellularity lymphocyte depletion and unclassified cases, most or all Reed Sternberg cells are reported to be positive for fascin. Fascin expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
IM20
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mM Sodium azide
Storage:
2-8°C
References 1:
Ishikawa R et al. The Journal of Biological Chemistry. 273 (41): 2699126997 (1998)
References 2:
Ono S et al. The Journal of Biological Chemistry. 272 (4): 25272533 (1997)
References 3:
Pinkus GS et al. American Journal of Pathology. 150 (2): 543562 (1997)
Folate is a basic component of cell metabolism and DNA synthesis and repair. It is involved in essential one-carbon transfer reactions and is a vitamin required by both normal and tumor cells. Folate entry into cells is facilitated via two different systems: the reduced folate carrier, which utilizes a bidirectional anion-exchange mechanism, and the folate receptor system. Folate receptor alpha is a membrane-bound member of the folate receptor family, facilitating folate transport via a mechanism termed potocytosis where the receptor is internalized and then recycled back to the cell membrane. Folate receptor alpha expression is reported to be highly restricted in normal tissues and only selectively overexpressed in a limited number of epithelial malignancies.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
BN3.2
Concentration:
Greater than or equal to 67 mg/L
Storage buffer:
Tissue culture supernatant with 15mM Sodium azide
Storage:
2-8°C
References 1:
Smith AE et al. Hybridoma. 2007; 26(5):281288
References 2:
Kelemen L. International Journal of Cancer. 2006; 119:243250
Analyte Specific Reagent. Analytical and performance characteristics are not established. Human gamma-sarcoglycan (35 kD). The product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG2b, kappa
Monosan Range:
MONXtra
Clone:
35DAG/21B5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is reported to be expressed in proliferating lymphocytes and epithelial cells, for example, germinal centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of the testes, within the basal layers of the squamous epithelium of the skin and breast. Geminin is reported to be upregulated in cancers such as non-Hodgkin's lymphoma, B cell lymphoma, breast carcinoma and colon carcinoma.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
EM6
Concentration:
Greater than or equal to 19 mg/L
Storage buffer:
Tissue culture supernatant with 15mM Sodium azide
Storage:
2-8°C
References 1:
McGarry TJ and Kirschner MW. Cell. 1998; 93:10431053
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein of 52kD reported to be expressed in glial cells, for example, astrocytes and ependymal cells. In the peripheral nervous system, GFAP has been reported to be expressed in Schwann cells, enteric glial cells and satellite cells of human sensory ganglia and in neoplastic tissues GFAP has been reported to be expressed in astrocytomas and ependymomas. When using GFAP-GA5 the heat induced epitope retrieval (HIER) technique may improve staining in some cases.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
GA5
Concentration:
Greater than or equal to 70 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Louis ED et al. Brain 7. 2007; 130:3297-3307
References 2:
Barresi V et al. Archives of Pathology and Laboratory 8. Medicine 2006; 130:1208-1211
References 3:
Biondo B et al. Acta Neuropathologica 2004; 108:309-318
Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
11F1
Concentration:
Greater than or equal to 47 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Lee HK et al. J Korean Med Sci. 2003; 18:272276
References 2:
Theate I et al.European Journal of Haematology. 2002; 69(4):248253
Gross cystic disease of the breast is a benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive apocrine cystic secretions. This fluid is composed of several glycoproteins including a unique 15 kD monomer protein, GCDFP15. It has been reported that cytosolic analysis of normal tissue from all major organs has demonstrated GCDFP15 in apocrine epithelia, lacrimal, ceruminous and Moll's glands and in numerous serous cells of the submandibular, tracheal, bronchial, sublingual and minor salivary glands. Specificity Human gross cystic disease fluid protein (15 kD)
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
23A3
Concentration:
Greater than or equal to 55 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Sapino A et al. J. of Biol.Regulators & Homeostatic Agents. 2000; 14(4):259262
References 2:
Haagensen DE Jr et al. Annals of the New York Academy of Sciences.1990;586:161173
Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation.
The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells. Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation. The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
HMB45
Concentration:
Greater than or equal to 10.8 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Swetter SM et al. Archives of Dermatology. 2004; 140:99-103
References 2:
Kapur RP et al. The Journal of Histochemistry and Cytochemistry. 1992; 40(2):207-212
References 3:
Gown AM et al. American Journal of Pathology. 1986; 123(2):195-203
Human herpesvirus type 8 (HHV8), is the proposed etiological agent of Kaposi's sarcoma (KS). It is reported that HHV8 has been demonstrated in KS tissues by immunohistochemistry, in situ PCR and also in situ hybridization. HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene ORF73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity. HHV8 has been reported to be expressed in multicentric Castleman's disease (MCD) and in angioimmunoblastic lymphadenopathies. The localization of HHV8 in subcapsular spindle cell proliferations, which is where early intranodal KS begins, and endothelial cells in Castleman's disease may explain the link between intranodal KS and MCD. In MCD, HHV8 is reported to be expressed in mantle zone large immunoblastic B cells.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
13B10
Concentration:
Greater than or equal to 35 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Pereira PF et al. 2013. Anais Brasileiros de Dermatologia 88;2:243- 46.
References 2:
Urquhart JL et al.The American Journal of Dermatopathology. 2006; 28(4): 317-321
References 3:
Cheuk W et al. American Journal of Clinical Pathology. 2004; 121(3): 335-342
ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.
Antibody Isotype:
IgG2b, kappa
Monosan Range:
MONXtra
Clone:
L453R
Concentration:
Greater than or equal to 449 mg/L
Storage buffer:
PBS with sodium azide
Storage:
2-8°C
References 1:
Orchard J et al. Leukaemia and Lymphoma 2005; 46(12):16891698
References 2:
Wang J et al. Applied Immunohistochemistry and Molecular Morphology 2005; 13(4):323332
References 3:
Mustelin T and Tasken K.Biochemical Journal 2003; 371:1527
References 4:
Van Oers N and Weiss A. Seminars in Immunology 1995; 7:227236
IgA is a member of the antibody class of the immunoglobulin superfamily. There are several classes and subclasses (isotypes) of antibody, the antibody isotype being defined by the immunoglobulin heavy chain present in the molecule. The basic structure of an immunoglobulin molecule consists of two identical heavy chains (gamma , mu, alpha , delta , epsilon) and two identical light chains, either kappa or lambda. IgA contains the alpha -chain and may be present in a serum or secretory form. In serum, 90% of IgA is monomeric, while in its secretory form it is the main immunoglobulin found in secretions including tears, saliva, intestinal and bronchial mucous, sweat, colostrum, and secretions from the prostate and respiratory epithelia, where it has the job of defending exposed external surfaces of the body against attack from micro organisms. Secretory IgA is synthesized locally by plasma cells and dimerized intracellularly with a cysteine-rich J-chain. Clone N1CLA was developed to produce reduced background staining that is associated with polyclonal antibodies on paraffin sections.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
N1CLA
Concentration:
Greater than or equal to 46 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Merluzzi S et al. Blood Journal. 2010; 115(14):2810-2817
References 2:
Fagarasan S and Honjo T. Current opinion in Immunology. 2004; 16(3):277-283
References 3:
Pilette C et al. European Respiratory Journal. 2001; 18:571-588
The human immunoglobulins consist of two identical heavy chains (~50 kD) and two identical light chains, which are linked together by disulphide bonds. The light chains can be either kappa or lambda. The five immunoglobulins IgA, IgD, IgE, IgG and IgM differ in their heavy chains, and IgA and IgM differ as they can occur in polymeric forms. The heavy chain of IgG is named the gamma-chain. In humans, IgG consists of four sub classes that differ only marginally in their amino acid composition. Antibodies to IgG have been reported to be useful in the identification of plasma cells, lymphoid cells containing IgG and classifying B cell derived neoplasms. The normal B cell population is polyclonal, expressing a range of different immunoglobulins. In contrast, the majority of B cell neoplasms are characterized by the proliferation of monoclonal cells expressing one type of light chain, whereas more than one type of heavy chain can be expressed by the same cell.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
RWP49
Concentration:
Greater than or equal to 59 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Karamchandani JR et al. American Journal of Clinical Pathology. 2012; 137: 699-711
References 2:
Janeway C et al.Chapter 3. Garland Science. New York and London. 2001
References 3:
Fridman W et al. FASEB Journal. 1991; 5: 2684-2690
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