Anti-hepatocyte specific antigen, also known as anti-Hep-Par1, recognizes both benign and malignant liver-derived tissues including such tumors as hepatocellular carcinoma. It recognizes both normal adult and fetal liver tissue. The typical pattern is a granular cytoplasmic staining. This antibody is useful in differentiating hepatocellular carcinomas with adenoid features from adenocarcinomas, either primary in the liver or metastatic lesions to the liver
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
OCH1E5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Minervini MI, et al. Mod Pathol. 1997; 10:686-92
References 2:
Chu PG, et al. Am J Surg Pathol. 2002; 26:978-88
References 3:
Wieczorek T, et al. Am J Clin Pathol. 2002; 118:911-21
References 4:
Fasano M, et al. Mod Pathol. 1998; 11:934-8
References 5:
Maitra A, et al. Am J Clin Pathol. 2001; 115:689-94
Human germinal center associated lymphoma (HGAL) protein is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the interfollicular and paracortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. Anti-HGAL has the highest overall sensitivity of detecting follicular lymphoma (FL) and in detecting the interfollicular and diffuse components of FL compared with antibodies against bcl2, LMO2, CD10, and bcl6. The addition of anti-HGAL to the immunohistologic panel is beneficial in the work-up of nodal and extranodal B-cell lymphomas, and the efficacy of anti-HGAL in detecting the follicular, interfollicular, and diffuse components of FL is of particular value in the setting of variant immunoarchitectural patterns
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-49
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Natkunam Y, et al. Blood. 2005; 105:397986
References 2:
Natkunam Y, et al. Blood. 2007; 109:298-305
References 3:
Younes SF, et al. Am J Surg Pathol. 2010; 34:1266-76
References 4:
Higgins RA, et al. Arch Pathol Lab Med. 2008; 132:441-6
Human herpesvirus type 8 (HHV-8) is the likely etiological agent of Kaposis sarcoma (KS). HHV-8 DNA sequences have been found in Kaposis sarcoma lesions, primary effusion lymphoma, and multicentric Castlemans disease via polymerase chain reaction and in situ hybridization. Latent nuclear antigen (LNA1, LNA, LANA-1), also known as ORF73, is a 222- or 234 kD protein that is consistently expressed in HHV8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
13B10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Corbellino M et al AIDS Res Hum Retroviruses.;12(8):651-7 (1996)
References 2:
Schwartz EJ et al. Am J Surg Pathol.;27(12):1546-50 (2003)
References 3:
Boulanger E et al. Am J Hematol.;76(1):88-91 (2004)
References 4:
Courville P et al. Ann Pathol.;22(4):267-76 (2002)
CD33, also known as gp67 or SIGLEC-3, is a 67 kDa glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. Although the precise physiological function of CD33 is unknown, it may mediate cell to cell adhesion and modulate inflammatory and immune response. In normal tissue, anti-CD33 labels myeloid cells (especially myeloid precursors), liver Kupffer cells, lung alveolar macrophages, and placental syncytiotrophoblasts. In neoplastic tissue, anti-CD33 is useful for the identification of acute myeloid leukemia.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
PWS44
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Freeman SD, et al. Blood. 1995; 85:2005-12
References 2:
Laszlo GS, et al. Oncotarget. 2016; 7:43281-94
References 3:
Crocker, PR et al. Biochem Soc Symp 2002; 69:83-96
Anti-GCDFP-15, mouse monoclonal (23A3), and anti-mammaglobin, mouse monoclonal (304-1A5) and rabbit monoclonal (31A5), is an antibody cocktail. GCDFP-15 is a 15 kDa glycoprotein which is localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. Mammaglobin (10 kDa) is a breast-associated glycoprotein distantly related to the secretoglobin family that includes human uteroglobin and lipophilin.This antibody cocktail is useful in identifying breast carcinoma.
Antibody Isotype:
IgG2a/IgG1/IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
23A3+(304-1A5+31A5)
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Cohen, C et al. Arch Pathol Lab Med. 1993; 117:291-4
References 2:
Bhargava R, et al. Am J Clin Pathol. 2007; 127:103-13
References 3:
Takeda Y, et al. Arch Pathol Lab Med. 2008; 132:239-43
References 4:
Tornos C, et al. Am J Surg Pathol. 2005; 29:1482-9
Neuron-specific enolase (NSE) is the glycolytic isoenzyme of the enolase gamma-gamma dimer specifically detected in neurons of neuroendocrine cells, and their corresponding tumors. In addition, NSE has been demonstrated immunohistochemically in the non-neoplastic cells of the pituitary, peptide secreting tissues, pineolocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. Anti-NSE immunostaining is also positive in normal striated muscle, hepatocytes and, to a lesser extent, smooth muscle. Anti-NSE is a useful marker to identify peripheral nerves.5 When used for the identification of neuroendocrine differentiation, it is suggested that it be employed in a panel with more specific markers such as anti-synaptophysin, anti-chromogranin, and anti-neurofilament.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-55
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wick MR, et al. Am J Clin Pathol. 1983; 79:703-7
References 2:
Vinores SA, et al. Arch Pathol Lab Med. 1984; 108:536-40
p21 is one of the inhibitors of the phosphorylation of the cyclin-cdk complex. p21, which is an inhibitor of G1 cdks, suppresses the cell cycle and inhibits DNA synthesis. Although p21 is induced by p53 and inhibits cdk (cyclin-dependent kinase) activity, there was virtually no correlation between the expression of p21 and that of p53; this finding was consistent with two reports, though another reported an inverse correlation between the expression of p21 and that of p53. p53independent expression of p21 might account for the discrepancy between the expression of p53 and that of p21. It is expressed in normal human tissue and a wide array of tumors.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
DCS-60.2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
The parathyroid glands function within the endocrine system to promote blood calcium homeostasis through controlled release of parathyroid hormone (PTH). This process involves the synthesis and secretion of PTH by activated parathyroid chief cells during conditions of hypocalcemia. With the anatomical proximity to the thyroid and capacity of associated neoplasms of the parathyroid to mimic thyroid tumors, challenges can arise in distinguishing between these types of abnormalities. In cases where there is uncertainty about a tumor being of parathyroid origin, immunohistochemical evaluation using anti-PTH can be of value.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-31
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Aldinger KA, et al. Cancer; 49:388-97 (1982)
References 2:
Brown EM. Mineral Electrolyte Metal; 8:130-50 (1982)
References 3:
Abate EG, et al. Front Endocrinol (Lausanne).; 7:172 (2017)
References 4:
Duan K, et al. Turk Patoloji Derg.; 31 Suppl 1:80-97 (2015)
References 5:
Chen HL, et al. Journal of Biology and Chemistry; 277:19374-81 (2002)
S100P is a member of the S100 family of proteins. The family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. Anti-S100P with nuclear or nuclear/cytoplasmic immunoreactivity can be seen in pancreatic ductal adenocarcinomas, while it is rarely detectable in benign pancreatic ducts. It may also help to distinguish urothelial carcinomas from other genitourinary neoplasms such as prostate carcinoma
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
16/f5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Lin F, et al. Am J Surg Pathol 2008; 32:78-91
References 2:
Deng HB. Am J Clin Pathol 2008; 129:81-8
References 3:
Nakata K et al. Hum Pathol 2010; 41:824-31
References 4:
Higgins JP, et al. Am J Surg Pathol 2007; 31:673-80
T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. TCL1 is expressed in differentiated Bcells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. The Anti-TCL1 immunohistochemical reactivity is reportedly useful identifying B-cell lymphomas including follicular lymphoma and Burkitt lymphoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-7
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Takizawa J, et al. Jpn J Cancer Res. 1998; 89:712-8
References 2:
Narducci MG, et al. Cancer Res. 2000; 60:2095-100
References 3:
Rodig SJ, et al. Am J Surg Pathol. 2008; 32:113-22
References 4:
Herling M, et al. Leukemia. 2006; 20:280-5
References 5:
Pescarmona E, et al. Histopathology. 2006; 49:343-8
IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%).
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-44
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Sakata N, et al., Am J Surg Pathol. 2008; 32:553-9
References 2:
Dhobale S, et al., J Clin Rheumatol. 2009; 15:354-7
References 3:
Li Y, et al., Pathol Int. 2009; 59:636-41
References 4:
Koyabu M et al., J Gastroenterol. 2010; 45:732-41
References 5:
Kamisawa T, et al., World J Gastroenterol. 2009; 21:2357-60
Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. Inhibin is a dimer that consists of an alpha and beta subunit. In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex. Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
R1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Stewart CJ, et al. Histopathology. 1997; 31:67-74
References 2:
McCluggage WG, et al. J Clin Pathol. 1998; 51: 114-6
References 3:
Kommoss F, et al. Mod Pathol. 1998; 11:656-64
References 4:
Guerrieri C, et al. Int J Gynecol Pathol. 1998; 17:266-71
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1 that differ by the variable inclusion of amino acids are potentially produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics [medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs)] is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-27
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Bourdeaut F, et al. J Pathol. 2007; 211:323-30
References 2:
Fowler DJ, et al. Fetal Pediatr Pathol. 2006; 25:159-68
References 3:
Haberler C, et al. Am J SurgPathol. 2006; 30:1462-8
References 4:
Janson K, et al. Pediatr Blood Cancer. 2006 Sep:47(3):279-84
The antibody detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
L1C1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hertel, BF, et al. Lab Invest 1977;36:12
References 2:
Mendes S, Dreno B. Acta Derm Venereol. 2003;83(3):167-70
References 3:
Lee LA et al. Am J Otolaryngol. 2002 Sep-Oct;23(5):316-20
References 4:
Taylor, CL Arch Pathol Lab Med 1978;12:113-121
References 5:
Schmid U et al. Am J Surg Pathol. 1995 Jan;19(1):12-20
Kidney-specific cadherin (Ksp-cadherin) is a member of the cadherin family of cell adhesion molecules that is found exclusively in the basolateral membrane of renal tubular epithelial cells of the distal tubules and collecting duct. Ksp-cadherin may be useful in distinguishing between renal neoplasms of distal nephron origin from those of proximal tubule origin.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-33
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
The antibody detects surface immunoglobulin on normal and neoplastic B-cells. Anti-lambda staining is seen in B-cell follicles of human lymphoid tissue. When dealing with B-cell neoplasms, the determination of light chain ratios remains helpful. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder is very likely.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
Lamb14
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hertel, BF, et al. Lab Invest 1977;36:12
References 2:
Taylor, CL Arch Pathol Lab Med 1978;12:113-121
References 3:
Abbondanzo SL et al. Ann Diagn Pathol. 1999 Oct;3(6):394
References 4:
Kurtin PJ et al. Am J Clin Pathol. 1999 Sep;112(3):319-29
References 5:
Ashton-Key M et al. Histopathology. 1996 Dec;29(6):525-31
MART-1 (also known as Melan A) is a melanocyte differentiation antigen. MART-1 is a transmembrane protein present in melanocytes of normal skin, retina, nevi, and most melanomas. MART-1 is a very useful marker for identifying metastatic melanomas.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
A103
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kageshita T et al. J Immunother 1997 Nov;20(6):460-5
References 2:
Yaziji H, et al. In J Surg Pathol. 2003 Jan;11(1):11-5
References 3:
Mocellin S et al. J Immunother. 2001 Nov-Dec;24(6):447-58
References 4:
Perez RP et al. Hum Pathol. 2000 Nov;31(11):1381-8
References 5:
Hoang MP et al. J Cutan Pathol. 2001 Sep;28(8):400-6
MART-1 (also known as Melan A) is a melanocyte differentiation antigen. It is present in melanocytes of normal skin, retina, nevi and in the majority of melanomas. Tyrosinase is an enzyme integral in the process of melanin synthesis, and found in most malignant melanomas. Therefore, this cocktail is useful for the identification of melanomas and melanocytic lesions
Antibody Isotype:
IgG2b/IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
M2-7C10 & T311
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
The antibody is a monoclonal, anti-melanoma antibody that reacts with an antigen that has yet to be identified.1 Notably used as a melanoma marker, KBA.62 also detects smooth muscle, basal cells of the epidermis and hair shaft epithelia of the skin.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
KBA.62
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Pages C, et al.. Hum Pathol. 2008; 39:1136-42
References 2:
Aung P, et al. Am J Surg Pathol. 2012; 36:265-72
References 3:
E Cohen-Knafo et al. J Clin Pathol. 1995; 48:826-831
References 4:
Kaufmann O, et al.. Mod Pathol, 1998 Aug; 11(8):740-6
The antibody s useful as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. Anti-PNL2 reactivity is identified in the cytoplasm of cutaneous and oral mucosal melanocytes. Anti-PNL2 labels intraepidermal nevi, while the dermal components of compound nevi are largely non-reactive.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
PNL2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigens present on immature melanosomes. Anti-HMB45 is useful for identifying amelanotic melanoma from other neoplastic lesions with similar morphology.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
HMB-45
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gown AM, et al. Am J Pathol. 1986; 123:195-203
References 2:
Wick MR, et al. Arch Pathol Lab Med. 1988; 112:616-20
References 3:
Abrahamsen HN, et al. Cancer. 2004; 100:1683-91
References 4:
Vaggelli L, et al. Tumori. 2000; 86:346-8
References 5:
Baisden BL, et al. Am J Surg Pathol. 2000; 24:1140-6
Hector Battifora mesothelial-1 (HBME-1) is a membrane antigen that exists in the microvilli of mesothelial cells and other epithelial cells. Anti-HBME-1 labels thyroid papillary carcinoma and follicular carcinoma but not normal thyroid making it a valuable marker for distinguishing thyroid malignacies from benign thyroid lesions. It has also been demonstrated to label mesothelial cells, both be
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
HBME-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Coli A, Bigotti G, et al. J Exp Clin Cancer Res. 2007 Jun;26(2):221-7
Mi is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
C5/D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Liegl B, et al. Am J Surg Pathol. 2008; 32:608-14
References 2:
Righi A, et al. Int J Surg Pathol. 2008; 16:16-20
References 3:
Weinreb I, et al.. Virchows Arch. 2007; 450:463-70
References 4:
Ohsie SJ, et al. J Cutan Pathol. 2008; 35:433-44
References 5:
Hornick JL, et al. Am J Surg Pathol. 2008; 32:493-501
MLH1 is a mismatch repair gene that is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MLH1 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
G168-728
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Christensen M et al. Cancer 2002;95: 2422-30
References 2:
Wright CL et al. Am J Surg Pathol. 2003;27: 1393-1406
References 3:
Renkonen E et al. J Clin Oncol 2003; 21: 3629-3637
References 4:
Hoedema R. et al. The American Surgeon 2003, May 69(5): 387-92
References 5:
Brueckl WM et al. Anticancer Research 2003; 23: 1773-1778
MSH2 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MSH2 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
G219-1129
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Christensen M et al. Cancer 2002;95: 2422-30
References 2:
Wright CL et al. Am J Surg Pathol. 2003;27: 1393-1406
References 3:
Renkonen E et al. J Clin Oncol 2003; 21: 3629-3637
References 4:
Hoedema R. et al. The American Surgeon 2003, May 69(5): 387-92
References 5:
Brueckl WM et al. Anticancer Research 2003; 23: 1773-1778
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