CD34 is a cell surface glycophosphoprotein expressed on human hematopoietic progenitor cells and can be used for identifying blast cells. CD34 is a marker for vascular endothelial cells and has been shown in literature to be highly sensitive for angiosarcomas and Kaposi's sarcomas. In addition, CD34 is expressed in soft tissue tumors such as gastrointestinal stromal tumors (GIST).
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
QBEnd/10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Civin, CL, et al., London Academic Press 1989:818-825
References 2:
Fina, L et al., Blood 1990;75:2417-2426
References 3:
Torlakovic G et al. Arch Pathol Lab Med. 2002 Jul;126(7):823-8
References 4:
Salizzoni M et al. Transplantation 2003 Sep 15;76(5):844-8
References 5:
Fanburg-Smith JC et al. Mod Pathol. 2003 Mar;16(3):263-71
Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical injury. In humans, at least 14 mucin genes have been identified that code for the mucin proteins. Reportedly, mucin expression is associated with tumor type of gastric carcinomas, with MUC2 being associated with mucinous carcinomas. Anti- MUC2 reactivity is seen in goblet cells of the small intestine and colon, and it is useful in immunohistochemistry for identifying colonic, gastric and esophageal carcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-18
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Chaves P, et al. Dis Esophagus. 2005; 18:383-7
References 2:
Leteurtre E, et al. World J Gastroenterol. 2006; 12:3324-31.
References 3:
Mino-Kenudson M, et al. Arch Pathol Lab Med. 2007; 131:86-90
References 4:
Mizoshita T, et al. Histol Histopathol. 2007; 22:251-60
References 5:
OConnell FP, et al. Arch Pathol Lab Med. 2005; 129:338-47
E-cadherin is an adhesion protein that is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, gastrointestinal tract and ovary. Another application involves the differentiation of ductal (which is membrane staining) vs. lobular cancer of the breast (which is cytoplasmic staining). It has also been shown to be positive in some thyroid carcinomas. A combination of E-cadherin and p120 catenin helps distinguish ductal carcinoma of the breast from lobular carcinoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP700Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Han AC, et al. Hum Pathol. 1997; 28:641-5
References 2:
Simsir A, et al. Diagn Cytopathol. 1999; 20:125-30
References 3:
Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8
References 4:
Acs G, et al. Am J Clin Pathol. 2001; 115:85-98
References 5:
Dabbs DJ, et al. Am J Surg Pathol. 2007; 31:427-37
Neuron-specific enolase (NSE) is the glycolytic isoenzyme of the enolase gamma-gamma dimer specifically detected in neurons of neuroendocrine cells, and their corresponding tumors. In addition, NSE has been demonstrated immunohistochemically in the non-neoplastic cells of the pituitary, peptide secreting tissues, pineolocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. Anti-NSE immunostaining is also positive in normal striated muscle, hepatocytes and, to a lesser extent, smooth muscle. Anti-NSE is a useful marker to identify peripheral nerves.5 When used for the identification of neuroendocrine differentiation, it is suggested that it be employed in a panel with more specific markers such as anti-synaptophysin, anti-chromogranin, and anti-neurofilament.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-55
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wick MR, et al. Am J Clin Pathol. 1983; 79:703-7
References 2:
Vinores SA, et al. Arch Pathol Lab Med. 1984; 108:536-40
The antibody is a monoclonal, anti-melanoma antibody that reacts with an antigen that has yet to be identified.1 Notably used as a melanoma marker, KBA.62 also detects smooth muscle, basal cells of the epidermis and hair shaft epithelia of the skin.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
KBA.62
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Pages C, et al.. Hum Pathol. 2008; 39:1136-42
References 2:
Aung P, et al. Am J Surg Pathol. 2012; 36:265-72
References 3:
E Cohen-Knafo et al. J Clin Pathol. 1995; 48:826-831
References 4:
Kaufmann O, et al.. Mod Pathol, 1998 Aug; 11(8):740-6
Alpha-Methylacyl-CoA Racemase (also known as AMACR or P504s) is an essential enzyme in the ?oxidation of branched-chain fatty acids. AMACR over-expression has been demonstrated in several cancers including colorectal, prostate, ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma. Staining with the antibody to this enzyme has been useful in identifying prostate carcinoma and prostatic intraepithelial neoplasia, as well as atypical adenomatous hyperplasia in formalin-fixed paraffinized tissue in morphologically difficult cases.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
13H4
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Browne TJ et al. Hum Pathol. 2004 Dec;35(12):1462-8
References 2:
Wu CL et al. Hum Pathol. 2004 Aug;35(8):1008-13
References 3:
Evans AJ. J Clin Pthol. 2003 Dec;56(12):892-7
References 4:
Beach R, Gown AM, et al. Am J Surg Pathol. 2002 Dec;26(12):1588-96
References 5:
Jiang Z, Wu CL, et al. Am J Surg Pathol. 2002 Sep;26(9):1169-74
CD61 also known as integrin beta chain beta 3 (ITGB3) is an integrin cell-surface protein associated with cellular adhesion and cell-surface mediated signaling. Immunohistochemical staining for CD61 can be useful in evaluating normal and abnormal megakaryocytes, which can aide in the identification of some hematopoietic malignancies. Anti-CD61 reactivity is also seen in platelets, osteoclasts and macrophages.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
2f2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Duperray A et al. Blood. 1989 Oct; 74(5):1603-11
References 2:
Goldman BI et al. Modern Pathology 14:589-594 (2001)
References 3:
Thiele J et al. Virchows Archiv B Cell Pathol (1990) 58:295-302
Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.1,2 To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors.3-5 Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
R4A
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
van der Loop FT, et al. J Cell Biol. 1996; 134:401-11
References 2:
Maake C, et al. J Urol. 2006; 175:1152-7
References 3:
Paner GP, et al. Am J Surg Pathol. 2010; 34:792-9
References 4:
Council L, et al. Mod Pathol. 2009; 22:639-50
References 5:
Coco DP, et al. Am J Surg Pathol. 2009; 33:1795-801
The antibody targets the capsid proteins VP1 and VP2 on Human Parvovirus. Parvovirus B19 infection has been implicated as a cause in spontaneous abortion in humans and thus application of this antibody to placental tissues in such cases is appropriate. Parvovirus B19 is also associated with erythema infectiosum (fifth disease) in children and acute arthritis in adults, as well as chronic hemolytic anemia, with some patients experiencing aplastic crisis.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
R92F6
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Loughrey AC et al. J Med Vir 39:97-100 (1993)
References 2:
Moore L et al. Med J Australia 159:344-345 (1993)
References 3:
Morey AL et al. J Path 166:105-108 (1992)
References 4:
ONeill HJ et al. 123: 125-134 (1992)
References 5:
Silverberg SG et al. Principles and Practice of Surgical Pathology and Cytopathology, 3rd edition. 1997; p. 219-220
Collagen Type IV is the major component of the basal lamina so antibodies to this molecule confirm its presence and reveal the morphological appearance of the structure. Normal tissue stains with this antibody in a fashion consistent with the sites of mesenchymal elements and epithelial basal laminae. Anti-Collagen IV can also be useful in the classification of soft tissue tumors; schwannomas, leiomyomas. Their well differentiated, malignant counterparts usually immunoreact with this antibody. The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma can be revealed by this antibody with greater reliability than non-specific stains (e.g. silver reticulum).
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
CIV22
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gould, VE, et al., Pathol Annul 1976;11:353-386
References 2:
McArdle, JP, et al., Int J Cancer 1984;34:633-638
References 3:
De Iorio P et al. Anticancer Res. 2001;21(2B):1395-9
References 4:
Maatta M et al. J Histochem Cytochem. 2001 Jun;49(6):711-26
References 5:
Schmehl K et al. Int J Colorectal Dis. 2000 Feb;15(1):39-48
Pneumocystis carinii is a fungal organism which is detected in human tissues (typically in lung in immunocompromised patients) in the trophozoite stage. Anti-Pneumocystis carinii antibody reacts with an epitope on the organism which is resistant to formalin, picric acid, paraffin, as well as alchohol and xylene. No cross-reactivity has been demonstrated with other fungi or parasitic organisms.
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
3F6
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A (NAPSA) and napsin B (NAPSB). Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung. In normal tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney. Napsin A is a useful marker for lung adenocarcinoma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-60
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jagirdar J. Arch Pathol Lab Med.; 132:384-96 (2008)
References 2:
Bishop JA, et al.. Hum Pathol.; 41:20-5 (2010)
References 3:
Ye J, et al. Appl Immunohistochem Mol Morphol.; 19:313-17 (2011)
References 4:
Mukhopadhyay S, et al. Am J Surg Pathol.; 35:15-25 (2011)
References 5:
Rawlings ND and Salvesen GS. Academic Press.; p.69-71 (2013)
Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. This antibody has shown cross-reaction with human intestinal alkaline phosphatase.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
NB-10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Paiva, J, et al. Am J Pathol 1984;111:156-165
References 2:
Burke, AP, et al. Hum Path 1988;19:663-670
References 3:
Wick, MR, et al. Hum Path 1987;18:946-954
References 4:
Saad RS et al. Appl Immunohistochem Mol Morphol. 2003 Jun;11(2):107-12
References 5:
Goldsmith JD et al. Am J Surg Pathol. 2002 Dec;26(12):1627-33
CDX-2 is a caudal-related homeobox transcription factor whose expression in the adult is normally present in the gastrointestinal (GI) epithelium. It is implicated in the development and maintenance of the intestinal mucosa. This protein is expressed immunohistochemically in the nuclei of normal GI epithelium. CDX-2 protein expression has been seen in GI carcinomas. Anti-CDX-2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also stain positively with this antibody, which limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma versus mucinous carcinoma of the ovary.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EPR2764Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60
References 2:
Erickson LA, et al. Endocr Pathol. 2004; 15:247-52
References 3:
Saqi A, et al. Am J Clin Pathol. 2005; 123:394-404
References 4:
Saad RS, et al. Am J Clin Pathol. 2004; 122:421-7
References 5:
Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9
Wilms tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed in tissues of mesodermal origin. The Wilms tumor gene encodes a protein that functions as a tumor suppressor gene. WT1 is detected in tumor cells of Wilms Tumor (also known as nephroblastoma) and mesothelioma. Additionally, WT1 expression has been found in ovarian serous carcinomas and some breast carcinomas.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
6F-H2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Charles AK; Moore IE; Berry PJ. Histopathology ; 30(4):312-4 (1997)
References 2:
Ordonez NG. Am J Surg Pathol 24(4):598-606, (2000)
References 3:
Foster MR, et al. Arch Pathol Lab Med; 125:1316-20 (2001)
References 4:
Nakatsuka S, et al. Mod Pathol; 19:804-14 (2006)
References 5:
May RJ, et al. Clin Cancer Res.; 13: 4547-55 (2007)
Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells (2), it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK Campbell et al demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Campbell LK, et al. Mod Pathol. 2003; 16:963-9
References 2:
Bassotti G, et al. J Clin Pathol. 2005; 58:973-7
References 3:
Mahalingam M, et al. J Cutan Pathol. 2001; 28:282-6.
References 4:
Mahalingam M, et al. J Cutan Pathol. 2006; 33:51-6.
CD99, as detected with a variety of antibodies, is expressed by virtually almost all Ewings sarcoma and primitive peripheral neuroectodermal tumors (ES/PNET) and demonstrates strong and diffuse membranous staining. Other tumors that may show CD99 expression include neuroendocrine carcinomas, mesenchymal chondrosarcomas, solitary fibrous tumors, synovial sarcomas, vascular tumors, small round blue cell tumors, lymphoblastic lymphoma, acute myeloid leukemia, and myeloid sarcoma.5 However, strong and diffuse membranous reactivity for CD99 favors ES/PNET over the other diagnostic considerations. The other CD99+ tumors usually show cytoplasmic and more heterogeneous staining. Therefore, when making a final diagnostic interpretation, CD99 must be considered in a panel with other antibodies.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EPR3097Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Rettig WJ, et al. Lab Invest. 1992; 66:133
References 2:
Fellinger EJ, et al. Amer J Surg Pathol. 1992; 16:746
References 3:
Ambros IM, et al. Cancer. 1991; 139:317
References 4:
Khoury JD. Adv Anat Pathol. 2005; 12:212-20
References 5:
Dabbs DJ. Theranostic and Genomic Applications. 2014; 126
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 is a useful marker for identifying hairy cell leukemia cells. ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia, it is therefore a useful marker for identifying hairy cell leukemia cells. By contrast, B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villous lymphocytes and patients with variant hairy cell leukemiaas defined by current morphologic, phenotypic, and clinical criteriaare ANXA1-negative. Additionally, aberrant expression of Annexin A1 has been reported in certain types of breast and gastric carcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Falini B, et al. Lancet.; 363:1869-70 (2004)
References 2:
Sobral-Leite M, et al. BMC Med.; 13:156 (2015)
References 3:
Cheng TY, et al. Cancer.; 118:5757-67 (2012)
References 4:
Sato Y, et al. Exp Ther Med.; 2:239-43 (2011)
References 5:
Wang KL, et al.. Clin Cancer Res.; 12:4598-604 (2006)
Herpes simplex virus is quite ubiquitous and is quite variable in its presentation in human disease. Type I usually infects the non-genital mucosal surfaces. It may affect the skin or internal organs (typically brain, lung, liver, adrenal gland, or GI tract) of immunocompromised individuals. This polyclonal antibody reacts with Type I Herpes viruses. There may be cross-reactivity with varicella zoster virus at higher concentrations. Cross-reactivity with CMV or Epstein-Barr virus is not seen with this antibody.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
The antibody s useful as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. Anti-PNL2 reactivity is identified in the cytoplasm of cutaneous and oral mucosal melanocytes. Anti-PNL2 labels intraepidermal nevi, while the dermal components of compound nevi are largely non-reactive.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
PNL2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
GATA binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.1 The human GATA3 gene has been mapped to chromosome 10p15.3 GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma. Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
L50-823
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Higgins JP, et al. Am J Surg Pathol. 2007; 31:673-80
CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and the majority of malignant melanomas. Anti-CD63 is a useful immunohistochemical marker for the identification of malignant melanoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
NKI/C3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Azorsa DO, et al. Blood. 1991; 78:280-4
References 2:
Barrio MM, et al. Hybridoma. 1998; 17:355-64
References 3:
Demetrick DJ,et al. J Natl Cancer Inst. 1992; 84:422-9
CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposis sarcoma, and tumors of smooth muscle origin.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
YR145
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Sircar K, et al. AM J Surg Pathol 23(4):377-389,1999
References 2:
Miettinen M et al. Am J Surg Pathol 24(2):211-222, 2000
References 3:
Miettinen M. et al. Am J Surg Pathol 23(9): 1109-1118
Anti-Cytokeratin (OSCAR) is well suited to distinguish epithelial carcino¬ma from non-epithelial malignancies and is used to aid epithelial tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin containing cells in epithelia during normal development and during the develop¬ment of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in recognizing epithelial cells, and carcinomas.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
OSCAR
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gown, AM, et al. Am J Clin Pathol 1985;84:413
References 2:
Battifora, H. Am J Surg Pathol 1988;12:24
References 3:
Lewis JE et al. Hum Pathol. 1997 Jun;28(6):664-73
References 4:
Mueller JD et al. Cancer. 2000 Nov 1;89(9):1874-82
References 5:
Sato F et al. Br J Surg. 2001 Mar;88(3):426-32
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