The antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-40
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wiedenmann, B, et al. Cell 1985;41:1017-1028
References 2:
Navone, F et al. J Cell Biol 1986;103:2511-2527
References 3:
Lyda MH et al. Hum Pathol. 2000 Aug;31(8):980-7
References 4:
Skacel M et al. Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):302-9
The antibody detects astrocytes, Schwann cells, satellite cells, enteric glial cells, and some groups of ependymal cells. This marker is mainly used to distinguish neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP672Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jessen, KR, et al. J Neurosci 1983;3:2206-2218
References 2:
Regner A et al. J Neurotrauma. 2001 Aug;18(8):783-92
References 3:
Nagashima G et al. Clin Neurol Neurosurg. 2002 May;104(2):125-31
References 4:
Choi, BH, et al. Science 1984;223:407-409
References 5:
Viale, G, et al. Virchows Arch A Pathol Anat 1991;418:339-348
Carbohydrate Antigen 19-9 (CA19-9) is a sialylated Lewis A blood group antigen. It is synthesized by glycosyltransferases and has been identified as a component of gangliosides, glycoproteins and mucins. Anti-CA19-9 reacts with epithelial cells of normal pancreas, stomach, and colon as well as various adenocarcinomas, including pancreatic, gastric, and colorectal adenocarcinomas.
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
121SLE
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Encabo G, et al., Bull cancer (Paris) 1986;73:256-9
References 2:
Wu E, et al. Clin Adv Hematol Oncol. 2013; 11:535
References 3:
Partyka K, et al. Proteomics. 2012; 12:2212-20
References 4:
Remmers N, et al. Clin Cancer Res. 2013; 19:1981-93
The antibody abels a 50kDa, multiple myeloma oncogen-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of terminal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma /leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-43
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Grossman A, et al. Genomics. 1996; 37:229-33
References 2:
Neresh KN. Haematologica. 2007; 92:267-8
References 3:
Van Imhoff GW, et al. J Clin Oncol. 2006; 24:4135-42
References 4:
Gualco G, et al. Appl Immunohistochem Mol Morphol. 2010; 18:301-10
Anti-cytokeratin 7 reacts with proteins that are found in most ductal, glandular, transitional, and biliary duct epithelial cells. Cytokeratin 7 (CK7) labeling can help distinguish between lung,breast carcinomas, and urothelial carcinomas that typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression.CK 7 is a common marker of primary lung adenocarcinomas (almost all cases) with a lower specificity since it is also observed in other primary lung carcinomas and non-pulmonary carcinomas.1 Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarian neoplasms.This antibody does not recognize intermediate filament proteins.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
OV-TL 12/30
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jerome MV, et al. Histopathology. 2004; 45:125-34
References 2:
Murray SK, et al. Am J Surg Pathol. 2004; 28:1154-62
References 3:
Ramalingam P, et al. Ann Diagn Pathol. 2003; 7:112-9
References 4:
McCluggage WG, et al. Histopathology. 2005; 47:231-247
References 5:
Roy S, et al. Arch Pathol Lab Med. 2011; 135:1601-5
Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes and in natural killer cells. Anti-Granzyme B has been useful in diagnosing Natural killer/T cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T cells have been shown to be an unfavorable prognostic indicator in Hodgkins disease.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kummer JA, et al. Clin Exp Immunol. 1995; 100:164-72
Cytokeratin 5 is an intermediate filament protein of 58 kD molecular weight within the cytokeratin family. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium. Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Epithelioid mesotheliomas are strongly positive in almost all cases, but a minority of pulmonary adenocarcinomas will show focal immunoreactivity. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with anti-CK 5. Anti-CK 5, along with antip63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-CK. This antibody, along with anti-CK 14, has found application in identifying basal-like breast carcinoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP1601Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ordonez NG. Human Pathology. 2007; 38:116
References 2:
Kargi A, et al. Appl Immunohistochem Mol Morphol.; 15:415420 (2007)
PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5.4 PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation.1,3 Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
24
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50
Cytokeratin 20 is a 46-kDa intermediate filament protein which reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells.1-4 Anti-Cytokeratin 20 is useful in the identification of specific types of these epithelial cells under normal hyperplastic and neoplastic conditions.3 Cytokeratin 20 has been detected in adenocarcinomas of the colon, stomach and biliary tract.5-7 Merkel cell carcinomas have shown reactivity. In contrast, carcinomas of the breast are generally non-reactive.
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Ks20.8
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Oct-4 is a transcription factor that functions in the regulation and maintenance of pluripotency in embryonic stem and primordial germ cells. Oct-4 immunoreactivity has been demonstrated in gonadal and extra-gonadal seminomas, dysgerminomas and embryonal carcinomas. In addition, the immunohistochemical detection of Oct-4 assists in the evaluation of intratubular germ cell neoplasia (IGCN).
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Cheng L, et al. J Pathol. 2007; 211:1-9
References 2:
Weissferdt A, et al. Hum Pathol. 2015; 46:376-83
References 3:
Browne P, et al. Am J Clin Pathol. 2003 Nov;120(5):767-77
References 4:
García-Cosío M, et al. Mod Pathol. 2004 Dec;17(12):1531-8
References 5:
Gibson SE, et al. Am J Clin Pathol. 2006 Dec;126(6):916-24
Smooth Muscle Myosin, heavy chain (SMMS-1) is a cytoplasmic structural protein that is a major component of the contractile apparatus of the smooth muscle cells. SMMS-1 is also a myoepitheliumassociated protein. Anti-SMMS-1 is a mouse monoclonal antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in distinguishing between benign sclerosing breast lesions and infiltrating carcinomas in difficult cases since it strongly stains the myoepithelial layer in the benign lesions while it is negative in the infiltrating carcinomas.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
SMMS-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Werling RW, et al. Am J Surg Pathol. 2003; 27:82-90
References 2:
Agoff SN, et al. Appl Immunohistochem Mol Morphol. 2001; 9:164-9
References 3:
Popnikolov NK, et al. Am J Clin Pathol. 2003; 120:161-7
References 4:
Lazard D, et al. Proc Natl Acad Sci USA. 1993; 90:999-1003
GCDFP-15 is a 15 kD glycoprotein which is localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, ear canal, and in salivary glands. GCDFP-15 positivity is seen in breast carcinomas. On the other hand, colorectal carcinomas, lung carcinoma, mesotheliomas rarely stain with this antibody. Because of its specificity for breast carcinoma, this antibody is often helpful in distinguishing metastasis of unknown primary.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
23A3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mazoujian G, et al. Am J Pathol. 1983; 110:105-12
References 2:
Liegl B, et al. Histopathology. 2007; 50:439-47
References 3:
Bhargava R, et al. Am J Clin Pathol. 2007; 127:103-13
References 4:
Tornos C, et al. Am J Surg Pathol. 2005; 29:1482-9
References 5:
Takeda Y, et al. Arch Pathol Lab Med. 2008; 132:239-43
Calponin is a 34 kD polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue. Anticalponin has been found to be useful in staining myoepithelium and is, therefore, useful for differentiating benign sclerosing adenosis of the breast from infiltrating ductal carcinoma. Calponin positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma3 of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP798Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wang NP, et al. Appl Immunohistochem. 1997; 5:141-151
References 2:
Nagao T, et al. Cancer. 1998; 83:1292-9
References 3:
Savara AT, et al. Mod Pathol. 1997; 10:1093-1100
References 4:
Fanburg-Smith JC, et al. Hum Pathol. 1999; 30:1336-43
References 5:
Hornick JL, et al. Am J Surg Pathol. 2003; 27: 1183-96
Cyclooxygenase 2 (COX-2) is an essential enzyme involved not only in the mediation of inflammation but also carcinogenesis. Increased expression of COX-2 has been shown in carcinomas of many organ systems including stomach, colorectum, breast and lung.
Antibody Isotype:
IgG-1
Monosan Range:
MONOSAN Ready To Use
Clone:
SP21
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Villin is an actin-binding glycoprotein that serves an important role in the maintenance of the microvilli brush border in gastrointestinal (GI) mucosal epithelium and its associated tumors. Recent immunohistochemical studies with villin have shown that villin is not only expressed in carcinomas of the gastrointestinal tract, but also in renal cell carcinomas, pancreatic carcinomas, endometrial carcinomas, as well as carcinomas of the ovary and lungs. In addition, positive villin expression may be seen in neuroendocrine/carcinoid tumors of the GI tract and lungs.
Antibody Isotype:
N/A
Monosan Range:
MONOSAN Ready To Use
Clone:
CWWB1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Robert W. Werling et al. Am J Surg. Path.2003; 27(3):303-310
References 2:
Tamboli P. et al Arch Pathol Lab Med 2002;126:1057-1063
References 3:
Zhang P. J. et al. Arch Pathol Lab Med. 1999;123:812-816
References 4:
Nishizuka S et al. Cancer Res. 2003 Sep 1;63(17):5243-50
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. CD56 is involved in cellcell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-42
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Langdon, SP et al. Cancer Research 1988; 48(21):6161-6165
References 2:
Kaufmann, O et al. Hum Pathol. 1997 Dec; 28(12): 1373-8
References 3:
Tao, J et al. Am J Surg Pathol. 2002 Jan; 26(1):111-8
References 4:
Ely, SA et al. Am J Pathol. 2002 Apr; 160(4): 1293-9
References 5:
Sumi, M et al. Leuk Lymphoma. 2003 Jan; 44(1): 201-4
The antibody is a B-cell marker that is generally used to complement CD20. This antibody will stain many of the same lymphomas as CD20, but also is more likely to stain precursor B-lymphoid leukemias than CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Anti-CD79a will stain many cases of acute promyelocytic leukemia (FAB-M3), but only rarely stains other types of myeloid leukemia.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
JCB117
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mason DY, et al., Eur J Immun; 22:2753-2756 (1992)
References 2:
Lin BT, Weiss LM. Hum Pathol.; 28(9):1083-90 (1997)
References 3:
Pilozzi E et al. J Pathol.; 186(2):140-3 (1998)
References 4:
Kurtin PJ et al. Am J Clin Pathol.; 112(3):319-29 (1999)
References 5:
Blakolmer K et al. Mod Pathol.; 13(70:766-72 (2000)
The parathyroid glands function within the endocrine system to promote blood calcium homeostasis through controlled release of parathyroid hormone (PTH). This process involves the synthesis and secretion of PTH by activated parathyroid chief cells during conditions of hypocalcemia. With the anatomical proximity to the thyroid and capacity of associated neoplasms of the parathyroid to mimic thyroid tumors, challenges can arise in distinguishing between these types of abnormalities. In cases where there is uncertainty about a tumor being of parathyroid origin, immunohistochemical evaluation using anti-PTH can be of value.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-31
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Aldinger KA, et al. Cancer; 49:388-97 (1982)
References 2:
Brown EM. Mineral Electrolyte Metal; 8:130-50 (1982)
References 3:
Abate EG, et al. Front Endocrinol (Lausanne).; 7:172 (2017)
References 4:
Duan K, et al. Turk Patoloji Derg.; 31 Suppl 1:80-97 (2015)
References 5:
Chen HL, et al. Journal of Biology and Chemistry; 277:19374-81 (2002)
Toxoplasma gondii is a spindle-to-oval-shaped protozoan which presents as an infection in humans of various sorts. The cyst (30 um) and trophozoite (7 um) stages can be identified in humans is such cases. This intracellular parasite is transmitted via raw/undercooked meat, contaminated soil, or by direct contact with an infected host. Infection in humans is usually associated with a variable degree of immunosuppression such as in pregnancy or immunosuppression due to various drugs.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
PU.1 is a transcription factor that has been shown to be important for normal B-cell development. PU.1 belongs to the ETS family of transcription factors. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the prepro stage. Very little is known about PU.1 function in later stages of B-cell development. PU.1 does not seem to play a role in the end-stage of B-cell development and is not expressed in plasma cells. PU.1 exerts an important role in the regulation of the expression of crucial B-cell proteins, such as immunoglobulin (Ig) genes, and CD20 and its putative binding sites were also identified in the promoters of CD79, CD10, and CD22. PU.1 binds to the 3 enhancer region of both the Ig kappa and lambda light chain genes and it also regulates the immunoglobulin heavy chain genes through the intron enhancer region.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EPR3158Y
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD15 is a carbohydrate antigen with the common trisaccharide structure 3-fucosyl-N-acetyllactosamine, also known as Lewis x (Lex) or stage-specific embryonic antigen 1 (SSEA-1).1-3 CD15 is expressed in myeloid cells and mediates neutrophil adhesion to dendritic cells.2-3 CD15 is also expressed in Reed-Sternberg cells and is thus a useful marker for identifying Hodgkins lymphoma.
Antibody Isotype:
IgM
Monosan Range:
MONOSAN Ready To Use
Clone:
MMA
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Pellegrini W, et al. Haematologica. 2007; 92:708-9
S100P is a member of the S100 family of proteins. The family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. Anti-S100P with nuclear or nuclear/cytoplasmic immunoreactivity can be seen in pancreatic ductal adenocarcinomas, while it is rarely detectable in benign pancreatic ducts. It may also help to distinguish urothelial carcinomas from other genitourinary neoplasms such as prostate carcinoma
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
16/f5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Lin F, et al. Am J Surg Pathol 2008; 32:78-91
References 2:
Deng HB. Am J Clin Pathol 2008; 129:81-8
References 3:
Nakata K et al. Hum Pathol 2010; 41:824-31
References 4:
Higgins JP, et al. Am J Surg Pathol 2007; 31:673-80
CD1a is a non-polymorphic, major histocompatibility complex, class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with ?-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating cells, and rare antigen-presenting cells of the lymph node. CD1a positivity has also been seen in Langerhans cell histiocytosis (histiocytosis X), and a subset of pre-T lymphoblastic lymphoma/leukemia (cortical T LBL/L).
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EP3622
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Krenacs L, et al. J Pathol. 1993; 171:99-104
References 2:
Angel CE, et al. Blood. 2009; 113:1257-67
References 3:
Emile JF, et al. Am J Surg Pathol. 1995; 19:636-41
References 4:
Stefano, AP et al. Br J Haematol. 1999; 105:394-401
The antibody has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, syncytio trophoblast, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
Antibody Isotype:
IgG2b-k
Monosan Range:
MONOSAN Ready To Use
Clone:
KP10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kihara M, et al. J Reprod Med. 2005; 50:307-12
References 2:
Romaguera RL, et al. Fetal Pediatr Pathol. 2004; 23:181-90
References 3:
Marjoniemi VM. Pathology. 2004; 36:109-19
References 4:
Jun SY, et al. Histopathology. 2003; 43:17-25
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