Thyroid peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of thyroid peroxidase (TPO) described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. Some studies have shown qualitative, as well as quantitative differences in thyroid peroxidase expression in thyroid cancer compared to normal tissue.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
AC25
Concentration:
Greater than or equal to 10.8 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Kimura S et al. Proceedings of the National Academy of Science USA 84: 5555-5559 (1987)
References 2:
De Micco C et al. Cancer 67(12): 30363041 (1991)
References 3:
Czarnocka B et al. Breast Journal Cancer 85(6): 875880 (2001)
References 4:
Tanaka T et al. Journal of Pathology 179: 8994 (1996)
Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
N1NK
Concentration:
Greater than or equal to 69 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Del Sordo R et al. Histology and histopathology. 2014; 29(1):101-106
References 2:
Miettinen M et al. American Journal of Surgical Pathology. 2014; 38(3):410-420
References 3:
Paine SML et al. Neuropathology and applied neurobiology. 2014; 40:544-550
References 4:
Antic T et al. American Journal of Pathology. 2011; 136:872-880
Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. Napsin A is reported to be predominantly expressed in lamellar bodies of type II pneumocytes, secondary lysosomes of alveolar macrophages, respiratory epithelium of terminal and respiratory bronchioles, plasma cells, within a subset of lymphocytes in normal lung, as well as in epithelial cells of renal tubules in normal kidney and is weakly expressed in normal spleen. Studies have reported that Napsin A is expressed in 90% of primary lung adenocarcinomas.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
IP64
Concentration:
Greater than or equal to 8.3 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Yamashita Y et al. Modern Pathology. 2015; 28: 111-11
References 2:
Kandalaft PL et al. American Journal of Clinical Pathology. 2014; 142: 830-836
Mismatch repair gene MutS Homolog 6 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutS protein homolog 6 (MSH6). MSH6 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.
Antibody Isotype:
IgG
Monosan Range:
MONXtra
Clone:
PU29
Concentration:
Greater than or equal to 200 mg/L
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Warren J et al. Molecular Cell. 2007; 26:579-592
References 2:
Marti T et al. Journal of Cellular Physiology. 2002; 191:28-41.
Mismatch repair gene hMLH1 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutL protein homolog 1 (MLH1). MLH1 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
ES05
Concentration:
Greater than or equal to 165 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Tamura G et al.World Journal of Gastroenterology 2006; 12(2): 192198
References 2:
Abdel-Rahman W et al. Critical Reviews in Oncology/Hematology 2006; 58: 208220
References 3:
Mitchell R et al. American Journal of Epidemiology 2002; 156:885902
References 4:
Kuismanen S et al. American Journal of Pathology 2000; 156(5): 17731779
CD33 antigen is reported to appear on myelomonocytic precursor cells after CD34 antigen expression. It then continues to be expressed on both the myeloid and monocyte lineages, although it is reported to be absent on granulocytes. It has been reported that expression of CD33 is restricted to monocytes, premyelocytes, myeloid blasts, some acute undifferentiated leukemias and acute lymphoblastic leukemias.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
PWS44
Concentration:
Greater than or equal to 417 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Bradshaw EM et al. Nature Neuroscience. 2013, 16(7): 848 852
References 2:
Hoyer JD et al. American Journal of Clinical Pathology. 2008; 129(2): 316 323.
The CD7 molecule is a membrane-bound glycoprotein of 40 kD and is the earliest T cell specific antigen to be expressed in lymphocytes. CD7 antigen is also the only early marker to persist throughout differentiation. The function and role of the CD7 molecule has not yet been fully identified, although the activation of T cells with gamma/delta receptors has been proposed based on mAb-induced activation. CD7 antigen is reported to be found on the majority of peripheral blood T cells, most natural killer cells and thymocytes.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
LP15
Concentration:
Greater than or equal to 351 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Leong FJW et al. The Journal of Histotechnology. 2002; 25(4):215-227
References 2:
Ormsby A et al. Journal of the American Academy of Dermatology. 2001; 45(3):405-413
Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is reported to be expressed in proliferating lymphocytes and epithelial cells, for example, germinal centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of the testes, within the basal layers of the squamous epithelium of the skin and breast. Geminin is reported to be upregulated in cancers such as non-Hodgkin's lymphoma, B cell lymphoma, breast carcinoma and colon carcinoma.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
EM6
Concentration:
Greater than or equal to 19 mg/L
Storage buffer:
Tissue culture supernatant with 15mM Sodium azide
Storage:
2-8°C
References 1:
McGarry TJ and Kirschner MW. Cell. 1998; 93:10431053
Prokaryotic recombinant protein corresponding to a 70 amino acid component of the N-terminal region of the cytokeratin 20 intermediate filament protein
Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
PW31
Concentration:
Greater than or equal to 37 mg/L
Storage buffer:
Tissue culture supernatant with 15 mM sodium azide
Storage:
2-8°C
References 1:
Campbell F and Herrington CS. Current Diagnostic Pathology. 2001; 7:113-122
References 2:
Leech SN et al. Journal of Clinical Pathology. 2001; 54:727-729
References 3:
Ferrari L et al. Anticancer Research. 1999; 19: 3415-3428
Calretinin is a calcium-binding protein of 29 kD that is a member of the family of so-called EF-hand proteins that also includes S-100 proteins. Calretinin is reported to be abundantly expressed in neurons. Outside the nervous system, calretinin is reported to be expressed in a range of cell types including mesothelial cells, steroid producing cells, (for example adrenal cortical cells, Leydig cells, ovarian theca interna cells, Sertoli cells, some neuroendocrine cells, eccrine sweat glands) and other cell types.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
CAL6
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Groves P et al. Acta Biochimica Polonica 2001, 48(1), 113-119
References 2:
Rogers JH .The Journal of Cell Biology 1987, 105, 1343-1353
Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. Clone LN10 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone LN10 recognizes T cells in thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
LN10
Concentration:
Greater than or equal to 32 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Krynitz B et al. Acta Dermato Venerologica. 2010; 90:379-385
Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
WT49
Concentration:
Greater than or equal to 44 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Omeroglu A and Omeroglu G. Arch Pathol Lab Med. 2003; 127:e347-e348
References 2:
Lee SB and Haber DA. Experimental Cell Research. 2001; 264:74-99
IL-6 is a multifunctional cytokine that is secreted by both lymphoid and non-lymphoid cells. It plays a key role in immune responses, hematopoiesis and is an important cytokine in cell proliferation and differentiation. It may also play an important role as an autocrine growth factor in metastatic prostate cancer. IL-6 has been reported to play a role in secretion or release of pituitary hormone in pituitary hormone secreting cells and adenomas. In addition, IL-6 has been suggested to have a trophic effect in nerve cells and to have a direct pathogenic role in CNS disorders. There are an increasing number of reports that cytokines of the IL-6 family play an important regulatory role in heart physiology.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
10C12
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM Sodium azide
Storage:
2-8°C
References 1:
Salgado R et al. International Journal of Cancer. 103 (5): 642646 (2003)
References 2:
Kurotani R et al. Modern Pathology. 14 (8): 791797 (2001)
References 3:
Menet E et al. European Cytokine Network. 12 (4): 639646 (2001)
References 4:
Ono S et al. Journal of the Neurological Sciences. 187 (12): 2734 (2001)
References 5:
Yasukawa K et al. The EMBO Journal. 6 (10): 29392945 (1987)
Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokeratins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
RN7
Concentration:
Greater than or equal to 17 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
van de Molengraft FJJM et al.Histopathology. 1993; 22:35-38
References 2:
van Niekerk CC et al. Journal of Pathology. 1991; 165(2):145-15
CD79b, also known as B29 and Ig-beta is thought to function in the cellular activation and signaling that occurs when surface immunoglobulin (Ig) on B cells binds antigen or becomes cross-linked by anti-Ig antibody. This function occurs with the formation of a membrane signaling complex that is associated with Ig at the surface of B cells. CD79b, together with CD79a, forms the B cell antigen receptor (mlg) complex.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
JS01
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Matutes E. Journal of Clinical Pathology. 55: 180183 (2002)
References 2:
McCarron K F et al. American Journal of Clinical Pathology. 113 (6): 805813 (2000)
References 3:
Moreau E J et al. American Journal of Clinical Pathology. 108: 378382 (1997)
CD11c is a member of the leukocyte integrin family of adhesion proteins. It is reported to be expressed in normal tissues, mainly on myeloid cells, for example, in bone marrow myelocytes, premyelocytes, metamyelocytes, non-segmented and segmented neutrophils with high levels reported on tissue macrophages and monocytes and with lowest levels in granulocytes. It is also reported to be expressed on NK cells, activated T cells, lymphoid cell lines, including hairy cell leukemias and a proportion of interdigitating dendritic cells.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
5D11
Concentration:
Greater than or equal to 30 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Barth TFE et al. Journal of Pathology. 2007; 211:305-313
References 2:
Venkatraman L et al. Modern Pathology. 2005; 18: 255A-256A 1183 Supplement 1
aveolin-1 is a major structural component of caveolae, which are vesicular invaginations present on the plasma membrane of different cell types. It plays a regulatory role in several signaling pathways and is reported to be most abundantly expressed in terminally differentiated mesenchymal cells such as smooth muscle cells, adipocytes and endothelial cells. High levels are also reported in fibroblasts where a fine granular membranous and diffuse cytoplasmic staining pattern is described.
Antibody Isotype:
IgG2a, kappa
Monosan Range:
MONXtra
Clone:
4D6
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Wiechen K et al. American Journal of Pathology. 158 (3): 833839 (2001).
References 2:
Scherer PE et al. PNAS. 93: 131135 (1996)
References 3:
Lisanti MP et al. Journal of Cellular Biology. 126 (1): 111126 (1994).
Pax genes are a family of developmental control genes that encode nuclear transcription factors and have been implicated in the control of mammalian development. Pax-5 is a B cell specific transcription factor that is expressed in pro B cells, pre-B and mature B cells, and subsequently in all stages of B cell development until the plasma cell stage in which it is downregulated.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
1EW
Concentration:
Greater than or equal to 29 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Hansson M et al. European Journal of Haematology. 2007; 79:159-165
Human fascin is a 55 to 58 kD actin-bundling protein, whose actin binding ability is regulated by phosphorylation. In normal tissues the detection of fascin is reported to be predominantly restricted to dendritic cells, and in the thymus has been observed only in medullary dendritic cells. In reactive nodes, interdigitating reticulum cells of T cell zones, cells in subcapsular areas, and cells of the reticular network express fascin. Variable expression is seen in follicular dendritic cells and endothelial cells. Lymphoid cells, myeloid cells and plasma cells do not express fascin; however, in cases of Hodgkin's disease, including nodular sclerosis, mixed cellularity lymphocyte depletion and unclassified cases, most or all Reed Sternberg cells are reported to be positive for fascin. Fascin expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
IM20
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mM Sodium azide
Storage:
2-8°C
References 1:
Ishikawa R et al. The Journal of Biological Chemistry. 273 (41): 2699126997 (1998)
References 2:
Ono S et al. The Journal of Biological Chemistry. 272 (4): 25272533 (1997)
References 3:
Pinkus GS et al. American Journal of Pathology. 150 (2): 543562 (1997)
E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
36B5
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Elston MS et al. J.of Clin.Endocrinology and Metabolism. 2009; 94(4):1436-1442.
References 2:
Munhoz NG et al. The Open Pathology Journal. 2009; 3:10-17
References 3:
Chetty R and Serra S. Histopathology 2008; 52: 325330
References 4:
Schott M et al. Endocrinology and Metabolism 2007; 92(9):3378- 3382
References 5:
Dansranjavin T et al. Oncology Reports. 2006; 15:1125-1131
The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
17C2
Concentration:
Greater than or equal to 51 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Curia MC et al. Modern Pathology. 2008; 21:7-14
References 2:
Ortega P et al. Clinical Cancer Research. 2008; 14(14):995-1001
References 3:
Daa T et al. J. of Exp.Clin.Cancer Research. 2005; 24(1):83-87
References 4:
Fadare O et al. World Journal of Surgical Oncology. 2005; 3(38)
References 5:
Gamachi A et al.Modern Pathology. 2003; 16(11):1124-1131
The neural cell adhesion molecules are a family of closely-related cell surface glycoproteins thought to play a role in embryogenesis, development and contact-mediated interactions between neural cells. The CD56 antigen (NCAM) consists of four major isoforms generated by differential splicing of the RNA transcript from a single gene located on chromosome 5. The CD56 antigen is expressed on neurons, astrocytes, Schwann cells, NK cells and a subset of activated T lymphocytes.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
CD564
Concentration:
Greater than or equal to 11 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Nakamoto Y et al. Clinical and Experimental Immunology. 2007; 147:296-305
References 2:
Wicherek L et al. Reproductive Biology and Endocrinology. 2006; 4:41
References 3:
Wicherek l et al. Journal of Reproductive Immunology. 2006; 70:119-131
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