Newmarket Scientific Product Search Results for estrogen receptor

Product Search Results: estrogen receptor
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Monosan

MONX10118

1 ml

£853.00

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Product Detail:	Mouse anti-Progesterone Receptor, clone 16 (monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	human
Immunogen:	Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor.
Applications:	IHC-P (1:100-1:200)
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.
Antibody Isotype:	IgG1
Monosan Range:	MONXtra
Clone:	16
Concentration:	Greater than or equal to 324 mg/L
Storage buffer:	Tissue culture supernatant with sodium azide
Storage:	2-8°C
References 1:	Hungermann D et al. Journal of Pathology 2002; 198: 487494

Monosan

MONX10178

1 ml

£876.00

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Product Detail:	Mouse anti-Epidermal Growth Factor Receptor, clone EGFR.113 (monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	human
Immunogen:	Prokaryotic fusion protein corresponding to the external domain of the epidermal growth factor receptor molecule.
Applications:	IHC-P (1:20)
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
Antibody Isotype:	IgG2a
Monosan Range:	MONXtra
Clone:	EGFR.113
Concentration:	Greater than or equal to 26 mg/L
Storage buffer:	Tissue culture supernatant with Sodium azide
Storage:	2-8°C
References 1:	Lodge AJ et al. Journal of Clinical Pathology. 2003; 56(4):300304
References 2:	Sriplakich S et al. BJU Int. 1999; 83(4):498503
References 3:	Inoue K et al. Acta Med Okayama 1998; 52(6):305310
References 4:	Tungekar MF and Linehan J. Journal of Clinical Pathology. 1998; 51:583587

Monosan

MONX11161

1ml

£845.00

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Product Detail:	Mouse anti-Polo-Like Kinase 1 (PLK-1), clone MJS1 (monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	human
Immunogen:	107 amino acids from central region of human PLK-1 protein.
Applications:	IHC-P (1:100)
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	Polo-Like Kinase-1 (PLK1) also known as Serine/Threonine Protein Kinase 13 is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis and maintenance of genome stability. PLK-1 localizes to centrosomes and kinetochores where it plays a key role in late prophase and prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells. Overexpression of PLK-1 is associated with tumor development, with elevated levels of expression reported in non-small cell lung cancers, head and neck, gastric, breast, ovarian, colon and several other cancer types.
Antibody Isotype:	IgG1, kappa
Monosan Range:	MONXtra
Clone:	MJS1
Concentration:	Greater than or equal to 320 mg/L
Storage buffer:	Tissue culture supernatant with sodium azide
Storage:	2-8°C

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