Cytoplasmic actins are part of the microfilament system of cytoskeletal proteins. Smooth muscle actin is found in vascular walls, intestinal muscularis mucosae and muscularis propria and in the stroma of various tissues. Enzyme pretreatment may enhance staining in some cases. Human alpha smooth muscle actin. Reactive with smooth muscle cells in blood vessel walls, gut wall, myometrium and arrectores pili of skin. Myoepithelial cells such as those in breast and salivary gland also contain actin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
alpha sm-1
Concentration:
Greater than or equal to 4,5 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Skalli O et al. The Journal of Cell Biology. 1986; 103:2787-2796
References 2:
Ramos JG et al. Endocrinology. 2003; 144(7):3206-3215
References 3:
Suárez-Vilela D and Izquierdo-Garcia FM. Histopathology. 2003; 43(4):398-400
References 4:
Vicario JH et al. Rev Fed Arg Cardiol. 2002; 31:441-449
References 5:
Barry-Lane PA et al. Journal of Clinical Investigation. 2001; 108(10):1513-1522
DES-DERII reacts with an 18 kD rod piece of the intermediate filament protein desmin (53 kD) in muscle cells. The antibody does not appear to recognize other intermediate filament proteins. In normal tissues, Clone DE-R-11 reacts with both striated (skeletal and cardiac) and smooth muscle cells. The labeling is confined to the Z bands in skeletal and cardiac muscle giving a characteristic striated appearance.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
DE-R-11
Concentration:
Greater than or equal to 27 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Beaton LJ et al. Journal of Physiology. 2002; 544(Pt3):849-859
References 2:
Barber A et al.The FASEB Journal. 2001; 15:1158-1168
References 3:
Debus E et al.The EMBO Journal. 1983; 2(12):2305-2312
References 4:
Baghdiguian S et al. Nature Medicine. 1999; 5(5):503-511
References 5:
Lyall F et al. American Journal of Pathology. 2001; 159(5):1827-1838
Cytokeratins are a large family of cytoskeletal proteins found in epithelial cells. They are co-ordinately synthesized in pairs so that at least one member of each family is expressed in each epithelial cell. Cytokeratins assemble into obligatory heteropolymers composed of type I (acidic) and type II (basic) polypeptides to form higher order tetramers and protofilaments. Basal cells of human epidermis express acidic keratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kD protein that is closely related to cytokeratin 6. Point mutations in the cytokeratin 5 gene at locus 12q11-q13 can cause various types of epidermolysis bullosa simplex. Cytokeratin 5 is also reported to be expressed in most epithelial and biphasic mesotheliomas. Clone XM26 is specific for the 58 kD intermediate filament protein known as cytokeratin 5. It is not cross-reactive with cytokeratin 6.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
XM26
Concentration:
Greater than or equal to 21 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
Bhargava R et al. The American Journal of Clinical Pathology . 2008; 130:724-730
References 2:
Laakso M e al. Clinical Cancer Research. 2006; 12(14):4185-4191
References 3:
Miettinen M et al. American Journal of Surgical Pathology. 2003; 27(2):150158
References 4:
Zhang RR et al. Breast Cancer Research. 2003; 5:R151R156
Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokeratins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
OV-TL 12/30
Concentration:
Greater than or equal to 67 mg/L
Storage buffer:
Tissue culture supernatant with Sodium azide
Storage:
2-8°C
References 1:
van de Molengraft FJJM et al.Histopathology. 1993; 22:35-38
References 2:
van Niekerk CC et al. Journal of Pathology. 1991; 165(2):145-15
Cytokeratins 14 and 5 are useful to distinguish stratified epithelial cell types from simple epithelial cell types. Cytokeratin 14 has been reported to be expressed in neoplasms of squamous cell origin.Clone LL002 reacts with the human cytokeratin intermediate filament protein (50 kD) identified as cytokeratin 14.
Antibody Isotype:
IgG3
Monosan Range:
MONXtra
Clone:
LL002
Concentration:
Greater than or equal to 24 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Reis-Filho JS et al. Journal of Clinical Pathology. 2004; 57:83-86
References 2:
Sivard P et al. Experimental Dermatology. 2003; 12(4):346355
References 3:
Fong LYY et al. Cancer Research. 2003; 63:186195
References 4:
Nagao T et al. Histopathology. 2001; 38(1):3036
References 5:
Nakayama H et al. Japanese Journal of Clinical Oncology. 1997; 27(6):427432
Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.
Antibody Isotype:
IgG2a, kappa
Monosan Range:
MONXtra
Clone:
Ks20.8
Concentration:
Greater than or equal to 9,26 mg/L
Storage buffer:
PBS (pH 7.6) with 1% BSA and sodium azide
Storage:
2-8°C
References 1:
Botta MC et al. Pathologica. 2001; 93(6):640-644
References 2:
Leech SN et al. Journal of Clinical Pathology. 2001; 54:727-729
References 3:
Tan J et al. Human Pathology. 1998; 29(4):390-396
References 4:
Longatto Filho A et al. Acta Cytol. 1997; 41(4):961-971
References 5:
Moll R et al. American Journal of Pathology. 1992; 140(2):427-447
Clone 5D3 reacts with human cytokeratin intermediate filament proteins of 52.5 kD and 45 kD, identified as cytokeratins 8 and 18, respectively. Clone 5D3 shares similar specificities to clone CAM5.2 (Angus B et al. Journal of Pathology. 153: 377-384 (1987)).
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5D3
Concentration:
Greater than or equal to 420 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Nadji M, Morales AR. Laboratory Medicine. 1983; 14:767
References 2:
Omata M et al. Am.J.of Clin. Pathol. 1980; 73:626
References 3:
Angus B et al. J.of Pathology. 1988; 155(1):7175
References 4:
Martin CA et al. Appl Immunohistochem Mol Morphol. 2001; 9(1):7073
References 5:
Mehes G et al. Am. J.of Pathol. 2001; 159(1):1720
Cytokeratins 5, 6 and 18 are reported to be expressed in a broad range of human epithelial tissues, from simple glandular epithelia to stratified squamous epithelia. These include epithelial cells that are ectodermal, mesodermal, or endodermal in origin. These cytokeratins have been reported to be expressed in tumor cells of epithelial origin and less commonly of mesothelial origin. Non-epithelial tumors such as lymphomas do not express these cytokeratins. The recognition of cytokeratin 18 on formalin fixed paraffin embedded sections using clone LP34 may be variable.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
LP34
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Lyall F et al. The American Journal of Pathology. 2001;159(5):1827-1838
References 2:
Yokozaki H et al. Japanese Journal of Clinical Oncology. 2000;30(2):101-104
References 3:
Lyall F et al. The American Journal of Pathology. 1999;154(4):1105-1114
Clones AE1 and AE3 are specific for the 56.5, 50, 50', 48 and 40 kD acidic cytokeratins as well as the 65 to 67, 64, 59, 58, 56 and 52 kD basic cytokeratins. The cocktail of clones AE1 and AE3 exhibit broad reactivity with two families of cytokeratin, acidic and basic.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
AE1/AE3
Concentration:
Greater than or equal to 225 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Nadji M, Morales AR. Laboratory Medicine. 1983; 14:767
References 2:
Omata M et al. Am.J.of Clin. Pathol. 1980; 73:626
References 3:
Su T et al. Diagnostic Pathology. 2014; 9: 179
References 4:
Zhao W et al. Int.J. of Clin. and Exp.Pathol. 2014; 7(11): 7951-7956
References 5:
Hammers HJ et al. Molecular Cancer Therapeutics. 2010; 9(6): 1525-1535
NCL-CK5/6/8/18, NCL-L-CK5/6/8/18 and RTU-CK5/6/8/18 react with human cytokeratins 5, 6, 8 and 18. These products are cocktails of monoclonal antibodies designed to recognize cytokeratins reported to be expressed in almost all epithelial tissues.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
5D3/LP34
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15 mMsodium azide
Storage:
2-8°C
References 1:
Hatzfeld M and Weber K. Journal of Cell Biology. 116: 157166 (1992)
References 2:
Angus B et al. Journal of Pathology. 155: 7175 (1988)
References 3:
Ghosh A K et al. British Journal of Haematology. 61: 2130 (1985)
References 4:
Gatter KC et al. Journal of Clinical Pathology. 35: 12531267 (1982)
Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes.Clone KM51 is specific for alpha-synuclein and is unreactive with beta-synuclein. Pretreatment of tissue sections with 98-100% formic acid is also recommended.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
KM51
Concentration:
n/a
Storage buffer:
Tissue culture supernatant with 15mM sodium azide
Storage:
2-8°C
References 1:
Baba M et al. American Journal of Pathology. 152 (4): 879884 (1998)
References 2:
Polymeropoulos MH et al. Science. 276: 20452047 (1997)
References 3:
Spillantini MG et al. Nature. 388: 839840 (1997)
References 4:
Weinreb PH et al. Biochemistry. 35 (43): 1370913715 (1996)
Neurofilaments constitute the main structural elements of neuronal axons and dendrites. Neurofilaments are composed of three major subunits referred to as the neurofilament triplet, with molecular weights of 68 kD, 160kD and 200 kD. Within tumors, only neoplastic cells of neural origin or those exhibiting neuronal differentiation, have been reported to express neurofilaments. NF-H (200 kD) polypeptide of human neurofilament. This antibody reacts with both phosphorylated and unphosphorylated forms of NF-H.
Protein gene product (PGP) 9.5 is a neuron-specific protein, structurally and immunologically distinct from neuron specific enolase. The protein which has a molecular weight of 27 kD was first identified by high resolution two dimensional PAGE. PGP9.5 expression has been reported in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. PGP9.5 is a member of the ubiquitin C-terminal hydroxylase family and is also concentrated within inclusion bodies suggesting that such structures may be metabolically active regions of the cells.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
10A1
Concentration:
Greater than or equal to 35 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Beresford L et al. Immunology. 2004; 111(1):118125
Synaptophysin is an integral membrane glycoprotein with a molecular weight of 38 kD. It is reported to occur in presynaptic vesicles of neurons in brain, spinal cord, retina, in similar vesicles of the adrenal medulla as well as in neuromuscular junctions. Synaptophysin may be involved in synaptic vesicle formation and exocytosis. Synaptophysin is reported to be expressed in a wide spectrum of neuroendocrine tumors including neuroblastomas, ganglioneuroblastomas, phaeochromocytomas, chromaffin and non-chromaffin paragangliomas. Synaptophysin is also reported to be expressed in neuroendocrine tumors of epithelial type including pituitary adenomas, islet cell tumors, medullary carcinomas of thyroid, parathyroid adenomas, carcinoids of the bronchopulmonary and gastrointestinal tracts, neuroendocrine carcinomas of the bronchopulmonary and gastrointestinal tract and neuronendocrine carcinomas of the skin.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
27G12
Concentration:
Greater than or equal to 42 mg/L
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Takeda S et al. Neuropathology. 2003; 23(4):254261
NCL-b-DG is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
43DAG1/8D5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 2:
Muschen M et al. Cancer Research. 61 (5): 20802084 (2001)
References 3:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
This antibody reacts with full-size calpain 3 (94 kD) plus an additional fragment at 30 kD in human skeletal muscle. A band of 94 kD is seen with rabbit and dog muscle while extracts of hamster muscle show reactivity with the 94 kD band and a larger species of approximately 110 kD. This 110 kD band is the principal immunoreactive species seen in rat muscle extracts. This antibody produces no bands with mouse, pig or chicken muscle. Reconstitute with the volume of sterile distilled water indicated on the vial label.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
Calp3d/2C4
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Anderson LVB et al. American Journal of Pathology. 153 (4): 11691179 (1998)
References 2:
Topaloglu H et al. Neuropediatrics. 28: 212216 (1997)
This antibody reacts with full-size calpain 3 (94 kD) plus an additional breakdown product at 60 kD in human skeletal muscle. The 94 kD band can be seen in muscle extracts from rabbit, mouse, dog, chicken, hamster, pig and rat. Degraded calpain 3 bands starting at approximately 60 kD are also usually present. Additional bands corresponding in size to calpains 1 and/or 2 can be detected in skeletal muscle from mouse, rat, chicken and hamster. Reconstitute with the volume of sterile distilled water indicated on the vial label.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
Calp3c/12A2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Anderson LVB et al. American Journal of Pathology. 153 (4): 11691179 (1998)
References 2:
Topaloglu H et al. Neuropediatrics. 28: 212216 (1997)
Analyte Specific Reagent. Analytical and performance characteristics are not established. The product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
Ham1/7B6
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Analyte Specific Reagent. Analytical and performance characteristics are not established. The product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG2b
Monosan Range:
MONXtra
Clone:
Ham3/17B2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the rod domain (between amino acids 1181 and 1388) of human dystrophin. Also reacts with skeletal, cardiac and smooth muscle dystrophin from normal mouse, rat, rabbit, dog, hamster and pig. No reactivity with mdx mouse tissue of DMD/BMD patients who have a gene deletion which removes the antibody binding site. No reaction is seen with chicken dystrophin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
Dy4/6D3
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the carboxy terminus (between amino acids 3669 and 3685) of human dystrophin. Also crosssreacts strongly with skeletal, cardiac and smooth muscle dystrophin from normal mouse, rat, rabbit, dog, chicken and hamster. No crossreactivity with mdx mouse tissue. Crossreacts very weakly with pig dystrophin.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
DY8/6C5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label. Reacts strongly with the amino terminal domain (between amino acids 321 and 494) of human dystrophin. Patient immunoreactivity indicates epitope is near exons 10 to 12. Epitope mapping suggests that sequences from amino acids 308 to 351 are involved in antibody binding. This region spans the junction of exons 9 and 10 and the epitope recognised may be part of a hinge region joining the amino domain to the central rod domain. No reactivity with DMD/BMD patients deleted for exons 10 to 12. No crossreaction is observed with mouse (high background only), rat, rabbit, dog, chicken, hamster and pig dystrophin.
Antibody Isotype:
IgG2a
Monosan Range:
MONXtra
Clone:
DY10/12B2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Analyte Specific Reagent. Analytical and performance characteristics are not established. Product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG1, kappa
Monosan Range:
MONXtra
Clone:
34C5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Blake DJ et al. Physiological Reviews. 82 (2): 291329 (2002)
References 2:
Oliveira AS et al. Arq Neuropsiquiatr. 50 (4): 478485 (1992
References 3:
Haginoya K et al. Journal of Neurology. 238 (7): 375378 (1991)
Analyte Specific Reagent. Analytical and performance characteristics are not established. NCL-EMERIN is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label.
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
4G5
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Muschen M et al. Cancer Research. 61 (5): 20802084 (2001)
References 2:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
The muscle-specific form of laminin, merosin, is composed of three chains: alpha 2, beta 1 and gamma 1.Analyte Specific Reagent. Analytical and performance characteristics are not established. Reacts strongly with laminin alpha 2 chain of merosin in human and rabbit skeletal muscle. No reaction is observed in muscle sections from mouse, rat, dog, chicken, hamster or pig. The product is a lyophilized tissue culture supernatant containing sodium azide as a preservative. The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label
Antibody Isotype:
IgG1
Monosan Range:
MONXtra
Clone:
Mer3/22B2
Concentration:
n/a
Storage buffer:
Lyophilized
Storage:
2-8°C
References 1:
Marafioti T et al. American Journal of Pathology. 162 (3): 861871 (2003
References 2:
Hess J et al. Molecular and Cellular Biology. 21 (5): 15311539 (2001)
References 3:
Re D et al. Cancer Research. 61 (5): 20802084 (2001)
References 4:
Luo Y and Roeder R G. Molecular and Cellular Biology. 15 (8): 41154124 (1995)
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