The antibody detects a formalin-resistant epitope that is expressed by Reed-Sternberg cells in classic Hodgkin lymphoma, the majority of anaplastic large cell lymphomas, primary cutaneous CD30 positive T-cell lymphoproliferative disorders and in embryonal carcinomas. Occasionally diffuse large B-cell lymphoma stains with this antibody. This antibody also stains plasma cells in paraffin-embedded tissue as well as reactive immunoblasts. The staining pattern of anti-CD30 in lymphoma and embryonal carcinoma is different, with the former being membranous and exhibiting Golgi zone accentuation in location, and the latter being membranous only.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Ber-H2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Schwarting R, et al., Blood 1989 (74):1678-1689
References 2:
Fonatsch C, et al., Genomics 1992 (14):825-826
References 3:
George DH et al. Am J Surg Pathol. 2003 Apr;27(4): 487-93
References 4:
Hedvat CV et al. Hum Pathol. 2002 Oct;33(10): 968-74
CD31 has cytoplasmic, membranous expression in non-neoplastic and neoplastic vascular endothelial cells.1 It has been used as a tool to identify the vascular origin of neoplasms such as angiosarcomas, Kaposi sarcomas and epithelioid hemangioendothelioma. Immunohistochemical study with CD31 has also been shown useful to detect areas of tumor lymphovascular invasion. Additionally, detection of weak diffuse cytoplasmic CD31 immunoreactivity has been seen in cases of various carcinomas with occasional membranous staining in ductal carcinomas of the breast as well as in intratumoral macrophages.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
JC70
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Parums DV, et al.. J Clin Pathol. 1990; 43:752-7
References 2:
Attanoos RL, et al. Thorax. 2000; 55:860-3
References 3:
Alexander-Sefre F, et al. J Clin Pathol. 2003; 56:786-8
CD34 is a cell surface glycophosphoprotein expressed on human hematopoietic progenitor cells and can be used for identifying blast cells. CD34 is a marker for vascular endothelial cells and has been shown in literature to be highly sensitive for angiosarcomas and Kaposi's sarcomas. In addition, CD34 is expressed in soft tissue tumors such as gastrointestinal stromal tumors (GIST).
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
QBEnd/10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Civin, CL, et al., London Academic Press 1989:818-825
References 2:
Fina, L et al., Blood 1990;75:2417-2426
References 3:
Torlakovic G et al. Arch Pathol Lab Med. 2002 Jul;126(7):823-8
References 4:
Salizzoni M et al. Transplantation 2003 Sep 15;76(5):844-8
References 5:
Fanburg-Smith JC et al. Mod Pathol. 2003 Mar;16(3):263-71
CD43 is a transmembrane protein involved in immune function and T-cell activation. AntiCD43 reactivity is seen in T lymphocytes, monocytes, and granulocytes. No reactivity has been observed in normal or reactive B-cells. Reportedly, anti-CD43 reactivity is seen in the majority of T-cell lymphomas and some low grade B-cell lymphomas. Therefore, anti-CD43 is a useful immunohistochemical marker for the identification of T-cell lymphomas and some low grade B-cell lymphomas
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MT1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Leong AS-Y, et al. 2nd edition. Grenwich Medical Media. London. 2003
References 2:
Dabbs DJ. Diagnositc Immunohistochemistry. Third Edition. Saunders. 2006
The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kD or hematopoietic variant (CD44s) that is found in mesodermal cells such as hematopoietic, fibroblastic, and glial cells, as well as in some carcinoma cell lines. Higher molecular weight isoforms have been described in epithelial cells (CD44v) and are thought to function in intercellular adhesion and stromal binding. While many human tumors express CD44, a positive correlation between CD44v expression and tumor dedifferentiation has been demonstrated. MON 3237 may be useful in discrimination of urothelial carcinoma in-situ from non-neoplastic changes in the urothelium.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-13
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hudson D, et al. Int. J. Cancer. 1996; 66:457-63
References 2:
East JA, et al. Eur J Cancer. 1993; 29A:1921-2
References 3:
Gadalla HA, et al. BJU Int. 2004; 93:151-5
References 4:
McKenney JK, et al. Am J Surg Pathol. 2001; 25:1074-8
References 5:
Lopez-Beltran A, et al. Anal Quant Cytopathol Histpathol. 2013; 35:121-9
Anti-CD45 (anti-leukocyte common antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; therefore a positive result is highly indicative of hematolymphoid origin. Certain types of hematolymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
2B11 & PD7/26
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mason, DY, Am Pathol 1987;128:1-4
References 2:
Hall PA, Histopathology 1988;13:149-160
References 3:
Kurtin, PJ, Hum Path 1985;16:353-365
References 4:
Maluf HM et al. Mod Pathol. 1995 Feb; 8(2): 155-9
References 5:
Caballero T et al. J Clin Pathol. 1995 Aug;48(8): 743-8
Anti-CD45RO labels an isoform of the CD45 antigen also known as leukocyte common antigen. Anti-CD45RO reacts with thymocytes, mature activated T-cells, and a subpopulation of resting T-cells while showing no reactivity with B-cells, making this antibody helpful in identifying T-cell neoplasms.
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
UCHL-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. CD56 is involved in cellcell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues. In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms. well
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
123C3.D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Langdon, SP, et al. Cancer Research 1988;48(21):6161-6165
References 2:
Moolenaar, CE, et al. Cancer Research 1990;50(4):1102-1106
References 3:
Sumi M et al. Leuk Lymphoma. 2003 Jan; 44(1): 201-4
References 4:
Kibbelaar, RE, et al. Euro J of Cancer 1991;27(4):431-435
References 5:
Michalides, R, et al. International J of Cancer Sup 1994;8:34-37
CD57, also known as HNK-1 (human natural killer-1), is a cell surface carbohydrate epitope expressed on terminally differentiated T-cells and subsets of natural killer (NK) cells.1 It has also been identified on cells of neural crest origin.2 Anti-CD57 is often used to visualize the non-neoplastic bystander T-cells that may form rosettes around the neoplastic lymphocyte-predominant (LP) cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).3
Antibody Isotype:
IgM-k
Monosan Range:
MONOSAN Ready To Use
Clone:
NK1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Kared H, et al. Cancer Immunol Immunother. 2016; 65:441-52
References 2:
Nielsen CM, et al. Front Immunol. 2013; 4:422
References 3:
Sattarzadeh A, et al. Exp Hematol Oncol. 2015; 4:27
Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells. CD5 expression is useful in distinguishing mature T-cell neoplasms and differentiating among mature small lymphoid cell malignancies. Anti-CD5 does not react with granulocytes or monocytes.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
4C7
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jones NH, et al., Nature 1986;323: 346-349
References 2:
Tan SH et al. Br J Dermatol. 2003 Sep;149(3): 542-53
References 3:
Chang CC et al. Mod Pathol. 2002 Oct;15(10): 1051-7
References 4:
Hatano B et al. Pathol Int. 2002 May-Jun;52(5-6): 400-5
References 5:
West RB et al. Am J Clin Pathol. 2002 Apr;117(4): 636-43
CD61 also known as integrin beta chain beta 3 (ITGB3) is an integrin cell-surface protein associated with cellular adhesion and cell-surface mediated signaling. Immunohistochemical staining for CD61 can be useful in evaluating normal and abnormal megakaryocytes, which can aide in the identification of some hematopoietic malignancies. Anti-CD61 reactivity is also seen in platelets, osteoclasts and macrophages.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
2f2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Duperray A et al. Blood. 1989 Oct; 74(5):1603-11
References 2:
Goldman BI et al. Modern Pathology 14:589-594 (2001)
References 3:
Thiele J et al. Virchows Archiv B Cell Pathol (1990) 58:295-302
CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and the majority of malignant melanomas. Anti-CD63 is a useful immunohistochemical marker for the identification of malignant melanoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
NKI/C3
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Azorsa DO, et al. Blood. 1991; 78:280-4
References 2:
Barrio MM, et al. Hybridoma. 1998; 17:355-64
References 3:
Demetrick DJ,et al. J Natl Cancer Inst. 1992; 84:422-9
The antibody marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; lymphomas are negative or show few granules. This antibody may be useful for the identification of myelomonocytic and histiocytic tumors. Since this detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also stain.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Kp-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells. Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes. Therefore, anti-CD71 is a useful marker for highlighting erythroid precursors in bone marrow specimens. Increased CD71 expression is also associated with active cell growth including neoplastic tumor growth and may be seen in various carcinomas such as thyroid carcinomas, lung carcinomas, breast carcinomas, hepatocellular carcinomas and colorectal carcinomas.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-48
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ponka P, et al. Int J Biochem Cell Biol. 1999; 31:1111-1137
References 2:
Sieff C, et al. Blood. 1982; 60:703-713
References 3:
Lesley J, et al. Cell Immunol.1984; 83:14-25
References 4:
Nakahata T, et al. Leuk Lymphoma. 1994; 13:401-409
References 5:
Marsee DK, et al. Am J Clin Pathology. 2010; 13:429-435
The antibody is a B-cell marker that is generally used to complement CD20. This antibody will stain many of the same lymphomas as CD20, but also is more likely to stain precursor B-lymphoid leukemias than CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Anti-CD79a will stain many cases of acute promyelocytic leukemia (FAB-M3), but only rarely stains other types of myeloid leukemia.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
JCB117
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mason DY, et al., Eur J Immun; 22:2753-2756 (1992)
References 2:
Lin BT, Weiss LM. Hum Pathol.; 28(9):1083-90 (1997)
References 3:
Pilozzi E et al. J Pathol.; 186(2):140-3 (1998)
References 4:
Kurtin PJ et al. Am J Clin Pathol.; 112(3):319-29 (1999)
References 5:
Blakolmer K et al. Mod Pathol.; 13(70:766-72 (2000)
CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin gene superfamily. While its precise function is not known, it is suggested that CD7 plays a role in T-cell interactions as it is one of the earliest T-cell lineage associated antigens expressed during T-cell ontogeny. CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoid and myeloid progenitors. CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukemias, and is therefore a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T cell neoplasms, it is the most common pan-T antigen to be aberrantly absent and its absence in a T cell population is a useful pointer to a neoplastic conversion.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-56
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hodak E, et al. J Am Acad Derma¬tol. 2006 Aug;55(2):276-84
References 2:
Stillwell R, et al. Immunol Res. 2001; 24:31-52
References 3:
Schanberg LE, et al. Proc Natl Acad Sci USA. 1991; 88:603-7
The CD8 (cluster of differentiation 8) antigen is a cell surface glycoprotein made up of two subunits alpha and beta.1 Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes. CD8 is also detected on NK cells, some thymocytes, some null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic Tcells.3 CD8 expression has been found to be negative in Mycosis Fungoides. Rarely does anti-CD8 label non-hematolymphoid neoplasms.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
C8/144B
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Rossi, ML, Sanchez, FC, et al., J Clin Path 1988;41:314-319
References 2:
Stein, H, Lennart, K, et al., Adv Cancer Res 1984;42:67-147
References 3:
Phan-Dinh-Tuy, F, Niaudet, P, et al., Mol Immun 1982;19:1649-1654
Anti-CEA is employed as a tool to assist in the distinction between adenocarcinoma and mesotheliomas, along with other markers such as calretinin, CK 5/6, D2-40, HBME-1, Napsin A, MOC31, and Ber-EP4. Anti-CEA positivity is seen in adenocarcinomas from the lung and colon, as well.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
CEA31
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Go, VLW, et al., Cancer 1976;37:562-566
References 2:
Delellis, RA, et al., Am J Clin Pathol 1978;50:587-594
References 3:
Abutaily AS et al. J Clin Pathol. 2002 Sep;55(9):662-8
References 4:
Bhatnagar J et al. Anticancer Res. 2002;22(3):1849-57
References 5:
Carella R. et al. Am J Surg Pathol. 2001 Jan;25(1):43-50
Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, thyroid, and parathyroid. Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
LK2H10
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Wilson, BS, et al., Am J Pathol; 115:458-468 (1984)
References 2:
Lyda MH, Weiss LM. Hum Pathol. 31(8):980-7 (2000)
References 3:
ontochristopoulous GJ et al. Dermatology.; 201(2):123-6 (2000)
References 4:
Qvigstad G et al. Histochem J.; 32(9):551-6 (2000)
Collagen Type IV is the major component of the basal lamina so antibodies to this molecule confirm its presence and reveal the morphological appearance of the structure. Normal tissue stains with this antibody in a fashion consistent with the sites of mesenchymal elements and epithelial basal laminae. Anti-Collagen IV can also be useful in the classification of soft tissue tumors; schwannomas, leiomyomas. Their well differentiated, malignant counterparts usually immunoreact with this antibody. The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma can be revealed by this antibody with greater reliability than non-specific stains (e.g. silver reticulum).
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
CIV22
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gould, VE, et al., Pathol Annul 1976;11:353-386
References 2:
McArdle, JP, et al., Int J Cancer 1984;34:633-638
References 3:
De Iorio P et al. Anticancer Res. 2001;21(2B):1395-9
References 4:
Maatta M et al. J Histochem Cytochem. 2001 Jun;49(6):711-26
References 5:
Schmehl K et al. Int J Colorectal Dis. 2000 Feb;15(1):39-48
Cytokeratin 14 is a member of the Type I family of cytokeratins and is generally expressed in the basal cell layer of squamous epithelium. The cytokeratin 14 protein forms a heterotetramer with homodimers of cytokeratin 5 to contribute to the structural integrity of the intracellular cytoskeletal network. Anticytokeratin 14 has immunohistochemical utility as an aid in distinguishing squamous cell carcinomas from other tumors of epithelial origin.
Antibody Isotype:
IgG3
Monosan Range:
MONOSAN Ready To Use
Clone:
LL002
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Reis-Filho JS et al. Appl Immunohistochem Mol Morphol; 11(1):1-8 (2003)
Anti-Cytokeratin 19 reacts with a wide variety of epithelium and epithelial malignancies including Adenocarcinomas of the Colon, stomach, pancreas, biliary tract, liver and breast. Perhaps the most useful application is the identification of Thyroid carcinoma of the Papillary type, although Follicular Carcinoma is also labeled by this antibody approximately 50-60% of the time.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
A53-B/A2.26
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Cerilli LA, et al. Am J Clin Pathol 2002;118:186-193
References 2:
Jain R, et al. Appl Immunohistochem Mol Morphol. 2010; 18:9-15
Cytokeratin 20 is a 46-kDa intermediate filament protein which reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells.1-4 Anti-Cytokeratin 20 is useful in the identification of specific types of these epithelial cells under normal hyperplastic and neoplastic conditions.3 Cytokeratin 20 has been detected in adenocarcinomas of the colon, stomach and biliary tract.5-7 Merkel cell carcinomas have shown reactivity. In contrast, carcinomas of the breast are generally non-reactive.
Antibody Isotype:
IgG2a-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Ks20.8
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Anti-CK 5/6 positivity is seen in nearly 100% of malignant mesotheliomas and in nearly 0% of lung adenocarcinomas. Anti-CK 5/6 positivity can be seen in undifferentiated large cell carcinoma as well as squamous carcinoma, and has been useful in recognizing spindle cell squamous cell carcinoma of the skin. Less than 10% of carcinomas of the breast, colon, and prostate stain positively for this marker. Anti-CK 5/6 has also been used successfully as a myoepithelial cell marker in the prostate and breast to determine malignancy.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
D5/16B4
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ordonez NG. Am J Surg Pathol 1998; 22(10):1215-1221
References 2:
Abarahams NA et al. Am J Clin Pathol. 2003 Sep;120(3):368-76
References 3:
Reis-Filho JS et al. Virchows Arch. 2003 Aug;443(2):122-32
References 4:
Lin L et al. J Cutan Pathol.2003 Feb;30(2):114-7
References 5:
Otterbach F et al. Histopathology. 2000 Sep;3793):232-40
Anti-Cytokeratin 5 & 6 is a marker for eptihelioid mesotheliomas. Anti-Cytokeratin 5 & 6 stains the cytoplasm of such cells. Anti-TTF-1 stains the nuclei in the case of lung adenocarcinomas and is negative in nearly all mesotheliomas. The nuclear vs. cytoplasmic staining pattern of this cocktail can be useful in distinguishing between mesothelioma and adenocarcinoma of the lung.
Antibody Isotype:
IgG1/IgG1/IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
D5/16B4 & 8G7G3/1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ordóñez NG. Am J Surg Pathol. 1998; 22:1215-21
References 2:
Jang KY, et al. Anal Quant Cytol Histol; 2001; 23:400-4
References 3:
Srodon M, et al. Hum Pathol. 2002; 33:642-5
References 4:
Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8
References 5:
Bejarano PA, et al. Arch Pathol Lab Med. 2003; 127:193-5
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