SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (apoptosis), or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-4
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gurney, E.G., et al. J Virl. 34:752-763 (1980)
References 2:
Huang, H., Reis,R. et al. Brain Pathol., 9:33-42 (1999)
References 3:
Arrington, A.S., et al. Molecular and Clinical Perspectives; 461-489 (2001)
BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC). BCL6 antibodies stain malignant cells in follicular lymphoma, diffuse large B-cell lymphomas, Burkitt lymphoma,4 classical Hodgkin lymphoma, as well as majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma. BCL6 expression has been also seen in anaplastic large cell lymphomas (ALCL)
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
GI191E/A8
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 Tcell development from naïve T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers or mantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B-cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-46
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Szabo SJ, et al. Cell. 2000; 100:665-69
References 2:
Jöhrens K, et al. Am J Surg Pathol. 2007; 31:1181-5
References 3:
Atayar C, et al. Am J Pathol. 2005; 166:127-34
References 4:
Dorfman DM, et al. Am J Clin Pathol. 2004; 122:292-7
Programmed death-1 (PD-1), also known as CD279, is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
NAT105
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Bolstad AI, et al. Arthritis Rheum. 2003 Jan;48(1):174-85
References 2:
Dorfman DM, et al. Am J Surg Pathol. 2006 Jul;30(7):802-10
References 3:
Hamanishi J, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3360-5
References 4:
Konishi J, et al. Clin Cancer Res. 2004 Aug 1;10(15):5094-100
References 5:
Mataki N, et al. Am J Gastroenterol. 2007 Feb;102(2):302-12
Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. Inhibin is a dimer that consists of an alpha and beta subunit. In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex. Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
R1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Stewart CJ, et al. Histopathology. 1997; 31:67-74
References 2:
McCluggage WG, et al. J Clin Pathol. 1998; 51: 114-6
References 3:
Kommoss F, et al. Mod Pathol. 1998; 11:656-64
References 4:
Guerrieri C, et al. Int J Gynecol Pathol. 1998; 17:266-71
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16nm crystalline particles. UPIII is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
AU-1
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Moll R, et al. Am J Pathol. 1995; 147:1383-97
References 2:
Olsburgh J, et al. J Pathol. 2003; 199:41-9
References 3:
Parker DC, et al. Am J Surg Pathol. 2003; 27:1-10
References 4:
Ohtsuka Y, et al. BJU Int. 2006; 97:1322-6
References 5:
Logani S, et al. Am J Surg Pathol. 2003 Nov;27(11):1434-41
The antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53.1 Positive nuclear staining with this antibody has been shown to be a factor in breast carcinoma, lung carcinoma, colorectal carcinoma, urothelial carcinoma, and ependymoma.2-8 Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma, as well as a marker for intratubular germ cell neoplasia.
Antibody Isotype:
IgG2b-k
Monosan Range:
MONOSAN Ready To Use
Clone:
DO7
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mauri FA et al. Int J Oncol 1999 Dec;15(6):1137-47
References 2:
Caffo O et al. Clin Cancer Res 1996 Sep;2(9):1591-9
References 3:
Bebenek M et al. Anticancer Res 1998 Jan-Feb;18(1B):619-23
References 4:
Midulla C et al. Anticancer Res 1999 Sep-Oct;19(5B):4033-7
References 5:
Moore BE et al. App.IHC and Mol. Morphol. 2001;9(3): 203 206
MLH1 is a mismatch repair gene that is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MLH1 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
G168-728
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Christensen M et al. Cancer 2002;95: 2422-30
References 2:
Wright CL et al. Am J Surg Pathol. 2003;27: 1393-1406
References 3:
Renkonen E et al. J Clin Oncol 2003; 21: 3629-3637
References 4:
Hoedema R. et al. The American Surgeon 2003, May 69(5): 387-92
References 5:
Brueckl WM et al. Anticancer Research 2003; 23: 1773-1778
CD25, Interleukin-2 receptor alpha chain, is the alpha subunit of the cell surface receptor which regulates regulatory T-cells. CD25 has been detected in various hematological malignancies including adult T-cell leukemia/lymphoma, and hairy cell leukemia. MON 3230 has also been useful in identifying mast cells in skin biopsies in the setting of Urticaria Pigmentosa, which is predictive of Systemic Mastocytosis.
Antibody Isotype:
IgG2b
Monosan Range:
MONOSAN Ready To Use
Clone:
4C9
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Hahn HP, et al. Am J Surg Pathol. 2007 Nov;31(11):1669-76
References 2:
Hollmann TJ, et al. Am J Surg Pathol. 2008 Jan;32(1):139-45
References 3:
Létourneau S, et al. Clin Immunol. 2009; 123:758-62
References 4:
De Totero D, et al.. Leuk Lymphoma. 1994; 104:412-9
References 5:
Qayyum S, et al. Archives of Pathology & Lab Med. 2014; 138:282-6
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. In another study, Pfaltz et al. have shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.
Monosan Range:
MONOSAN Ready To Use
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Bickerstaff A, et al. Am J Pathol. 2008; 173:347-57
References 2:
Kuypers DR, et al. Transplantation. 2003; 76:102-8
Beta-catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. Mutations in the beta-catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis (desmoid tumors) of the breast and abdomen and, therefore, is useful in differentiating from other spindle cell neoplasms that may occur in these locations.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
14
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Alman BA, et al. Am J Pathol. 1997; 151:329-34
References 2:
Li C, et al. Am J Pathol. 1998; 153:709-14
References 3:
Abraham SC, et al. Hum Pathol. 2002; 33:39-46
References 4:
Montgomery E, et al. Am J Surg Pathol. 2002; 26:1296-301
CD14 is a 55kDa glycosyl-phosphatidylinositol-linked membrane protein, involved in endotoxin binding and recognition of apoptotic cells. CD14 is expressed on monocytes, macrophages, follicular dendritic cells, and granulocytes. Anti-CD14 can detect these cells, including monocyte-derived cells which are frequently increased in diffuse large B-cell lymphoma (DLBCL), as well as in neoplastic cells in acute myeloid leukemia with monocytic differentiation and chronic myelomonocytic leukemia.
Antibody Isotype:
IgG
Monosan Range:
MONOSAN Ready To Use
Clone:
EPR3653
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Gregory CD, et al. Apoptosis. 1999; 4:11-20
References 2:
Wright SD, et al. Science. 1990; 249: 1431-33
References 3:
Marmey B, et al. Hum Pathol. 2006; 37:68-77
References 4:
Smeltzer JP, et al. Clin Cancer Res. 2014; 20:2862-72
References 5:
Rollins-Raval MA, et al. Histopathology. 2012; 60: 933-42
Podoplanin is a transmembrane mucoprotein (38 kD) recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, and Kaposi sarcomas. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas and seminomas.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
D2-40
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Ordóñez NG. Adv Anat Pathol. 2006; 13:83-8
References 2:
Niakosari F, et al. Arch Dermatol. 2005; 141:440-4
CD2 is a surface antigen present on all peripheral T-cell lymphocytes. CD2 is associated with signaling and mediating adhesion to other T-cells through the lymphocyte function-associated antigen and CD48/BCM1 complex. MON 3225 is a useful immunohistochemical reagent for identification of normal T-lymphocytes, and for assessing lymphoid malignancies.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-11
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Aguilera NS, et al. Arch Pathol Lab Med. 2006; 130:1772-9
References 2:
Barrionuevo C, et al. Appl Immunohistochem Mol Morphol. 2007; 15:38-44
References 3:
Bovenschen HJ, et al. Br J Dermatol. 2005; 153:72-8
References 4:
Foon KA, et al. Blood. 1986; 68:1-31
References 5:
Gonzalez L, et al. Journal of Comparative Pathology 2001; 125:41-7
Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues.1 Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression.2 Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes.1,2 In conjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelial origin, such as distinguishing between lung adenocarcinoma and mesothelioma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
MOC31
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Schnell U, et al. Biochim Biophys Acta. 2013; 1828:1989-2001
MART-1 (also known as Melan A) is a melanocyte differentiation antigen. It is present in melanocytes of normal skin, retina, nevi and in the majority of melanomas. Tyrosinase is an enzyme integral in the process of melanin synthesis, and found in most malignant melanomas. Therefore, this cocktail is useful for the identification of melanomas and melanocytic lesions
Antibody Isotype:
IgG2b/IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
M2-7C10 & T311
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately most primary renal cell carcinomas and can aid in the diagnosis when renal cell carcinoma enters the differential diagnosis. Other tumors that may react with this antibody are parathyroid adenoma, an occasional breast carcinoma. Nephroblastoma, oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
PN-15
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Dabbs, D. 4th Edition. Elsevier Saunders. 2014; p234
References 2:
Bakshi N, et al. Appl Immunohistochem Mol Morphol. 2007; 15:310-5
References 3:
McGregor DK, et al. Am J Surg Pathol. 2001; 25:1485-92
References 4:
Avery, AK et al. Am J Surg Pathol 24(2): 203-210, 2000
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-23
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Chu PG, et al. Ann Diagn Pathol. 1999; 3:104-33
References 2:
Bittmann I, et al. Arch. 2004; 445:375-81
References 3:
dAmore ES, et al. Pediatr Dev Pathol. 2007; 10:181-91
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells. It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma. ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineageassociated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL. Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers. Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
B-A38
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Chilosi M, et al. Mod Pathol. 1999; 12:1101-6
References 2:
Sebestyén A, et al. Br J Haematol. 1999; 104:412-9
References 3:
Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8
References 4:
OConnell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
References 5:
Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47
Myogenin also identified as myogenic factor 4 is a muscle specific transcription factor associated with muscle differentiation and cell cycle.1 Anti-myogenin reactivity is seen in the nuclei of myoblasts in developing muscle tissue. Anti-myogenin is a useful immunohistochemical reagent for identification of rhabdomyosarcoma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
F5D
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Miller JB. J Cell Biol.; 111:1149-59 (1990)
References 2:
Wang NP, et al. Am J Pathol.; 147:1799-810 (1995)
References 3:
Cui S, et al. Pathol Int.; 49:62-8 (1999)
References 4:
Kaspar et al. Sci Rep.; 5:15090 (2015)
References 5:
Rudzinski et al. Am J Surg Pathol.; 38:654-9 (2014)
The antibody recognizes a human breast carcinoma associated glycoprotein BCA-225 (220-225kD). This protein differs in size and distribution from other breast carcinoma antigens. Anti-BCA-225 primary antibody labels breast cancer antigen 225 (BCA-225) in primary and metastatic breast carcinoma. BCA-225 was first identified in T47D breast carcinoma cells, but its expression in other carcinomas such as lung, kidney, ovary and endometrium has
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
Cu-18
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Mesa-Tejada R, et al. Am J Pathol; 1988 130:305-14
Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical injury. In humans, at least 14 mucin genes have been identified that code for the mucin proteins. Mucin genes are expressed in a regulated cell- and tissue-specific manner. The stomach provides a good example of such differential expression of mucin genes. MUC1 is detected in mucous cells of the surface epithelium and neck region of the gastric antrum, as well as in pyloric glands and oxyntic glands of the body region. The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN Ready To Use
Clone:
MRQ-17
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Chaves P, et al. Dis Esophagus. 2005; 18:383-7
References 2:
Leteurtre E, et al. World J Gastroenterol. 2006; 12:3324-31.
References 3:
Mino-Kenudson M, et al. Arch Pathol Lab Med. 2007; 131:86-90
References 4:
Mizoshita T, et al. Histol Histopathol. 2007; 22:251-60
References 5:
OConnell FP, et al. Arch Pathol Lab Med. 2005; 129:338-47
Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues. Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show EpCAM expression. Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes. In conjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelial origin, such as distinguishing between lung adenocarcinoma and mesothelioma.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
Ber-EP4
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Schnell U, et al. Biochim Biophys Acta. 2013; 1828:1989-2001
Human cytomegalovirus (CMV) is a ?-herpesvirus (human herpesvirus 5) that causes widespread persistent infection. CMV continues to be an important opportunistic pathogen in immunocompromised patients. It is estimated that 30% of transplant recipients experience CMV disease. The range of organ involvement in post-transplant CMV disease is wide; hepatitis occurs in 40% of liver transplant recipients, and pneumonitis is more frequently seen in heart and heart-lung transplant patients. Other organs that are commonly affected are the gastrointestinal tract and the peripheral and central nervous systems. Histologic diagnosis of CMV in fixed tissues usually rests on identifying characteristic cytopathic effects including intranuclear inclusions, cytoplasmic inclusions, or both, especially in the endothelial cells. However, histologic examination lacks sensitivity, and in some cases atypical cytopathic features can be confused with reactive or degenerative changes.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
8B1.2,1G5.2&2D4.2
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Drummer, JS et al. J Infect Dis 1985; 152:1182-1191
References 2:
Cote, L et al. J Clin Microbiol 1993; 31:2066-2069
CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. MON 3027 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas. Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.
Antibody Isotype:
IgG2a
Monosan Range:
MONOSAN Ready To Use
Clone:
2G9
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Dillon KM et al. J Clin Pathol.; 55(10):791-4 (2002)
References 2:
Cheuk W, et al. Am J Surg Pathol.; 25:721-31 (2001)
References 3:
Pileri SA, et al.Histopathology.; 41:1-29 (2002)
References 4:
Maeda K, et al. J Histochem Cytochem.; 50:1475-1486 (2002)
References 5:
Biddle DA, et al. Mod Pathol.; 15:50-8 (2002)
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