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Agrisera

AS00 001

50 µg

£317.00

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Background Info:	Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII).
Product Type:	Antibody
Antibody Type:	Polyclonal
Format:	Lyophilized
Storage Temp:	Store lyophilized/reconstituted at -20 °C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them, to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Host Animal:	Rabbit
Species Reactivity:	Human
Expected Species:	Primates
Immunogen:	Recombinant human Factor VIIa (NovoSeven , Novo Nordisk A/S Denmark)
Applications:	Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	This antibody is purified using Protein G, to obtain a total IgG fraction
Application Details:	1 : 15 000 (I-ELISA), 14 g/ml (IL)
Purity:	Immunogen affinity purified IgG in PBS pH 7.4.
Reconstitution:	For reconstitution add 50 l of sterile water
Molecular Weight:	52 kDa (this is MW of Factor VIIa)
Not reactive in:	No confirmed exceptions from predicted reactivity are currently known
Selected references:	Lopez-Vilchez et al. (2009). Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1). (immunolocalization)
Special application note:	No significant difference in binding to Factor VII and Factor VIIa.Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
UniProt number:	Q9FI56 , Q9SXJ7
Research area:	Immunology

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FVIIa | Coagulation factor VIIa (50 µg)