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Product Search Results: SPC-200D

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Product Search Results: SPC-200D

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StressMarq SPC-200D 100 µg £234.00
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Product Detail: This antibody is available conjugated to the following 23 tags: AP (Alkaline Phosphatase), HRP (Horseradish peroxidase), Biotin, Streptavidin, Dylights 350, 405, 488, 594, 633, APC/Cy7; ATTO 390, ATTO 488, ATTO 565, ATTO 594, PE/ATTO594, ATTO633, ATTO 655, ATTO 680, ATTO700, FITC, R-PE, APC, PerCP. Please call for pricing.
Background Info: The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa (6).
Product Type: Antibodies
Format: PBS, 50% glycerol, 0.09% sodium azide
Storage Temp: -20ºC
Host Animal: Rabbit
Species Reactivity: Hu | Ms
Immunogen: Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4
Applications: WB | IHC | ICC/IF | FCM | FACS
Application Details: WB (1:500), IHC (1:50); optimal dilutions for assays should be determined by the user.
Research Area(s): Immunology | Innate Immunity | Macrophage | Immunology | Immunoglobulins | Immunoglobulin Receptors | Cardiovascular System | Atherosclerosis | Vascular Inflammation | Inflammatory Mediators | Immunology | Adaptive Immunity | Regulatory T Cells | Immunology | Innate Immunity | TLR Signaling
Target: TLR4
Conjugate: Unconjugated
Alternative Name(s): ARMD10 Antibody, CD284 Antibody, TLR 4 Antibody, TOLL Antibody, Toll like receptor 4 Antibody
Category: Polyclonal
Immunogen Species: Human
Accession Number: NP_612564.1
Gene ID: 7099
Swiss-Prot: O00206
Species Reactivity Full Name: Human | Mouse
Purification: Protein A Purified
Concentration: 1 mg/ml
Specificity: Detects ~75-80kDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
Certificate of Analysis: 2 µg/ml of SPC-200 was sufficient for detection of TLR4 in 100 ng of partial recombinant mouse TLR4 protein by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cellular Localization: Membrane
References: 1. Muzio M., Natoli G., Saccan S., Levrero M., and Mantovani A. (1998) J. Exp. Med. 187: 2097-2101.
2. Medzhitov R. and Janeway C.A (1997) Cell. 91: 295-298.
3. Chuang T.H. and Ulevitch R.J. (2001) Biochim. Biophys. Acta. 1518(1-2): 157-161.
4. Takeuchi O., et al. (1999) Immunity. 11: 443.
5. Poltorak A., Riccardi-Castagnoli P., Citterio S., and Butler B. (2000) Proc. Natl. Acad. Sci USA. 97: 2163-2167.
6. Medzhitov R., Preston-Hurlburt P. and Janeway C.A. (1997) Jr. Nature. 388(6640): 394-397.
Tarriff Code: 3002.15.0000
ADR Code: Non-hazardous
UN Code for transport: Non-hazardous
Country of Origin: Canada
Cite this Product: StressMarq Biosciences Cat# SPC-200D, RRID: AB_2204998