Newmarket Scientific
Newmarket Scientific








Neuroscience Research


Proteins, antibodies, kits and other reagents for neuroscience


Affinity Biosciences logo   Agrisera logo     Biosensis logo   ImmunoStar logo  NS Reagents logo  

 


 

Newmarket Scientific provides Antibodies, Proteins, Kits and related reagents for neuroscience research.

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



Tdp 43 3 cat aa17 100105

TDP43 Antibodies

 

TAR DNA-binding protein 43 (TDP43) binds DNA and RNA and has multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation.

 

Characterisation of transcriptome-wide binding sites shows that thousands of RNAs are bound by TDP43 in neurons.

 

Hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). As well as...  read more

 



Shinning bright with Biosensis Amylo-Glo!
Amylo glo

 

Beautifully stain amyloid plaques in tissues in multi-labelling and low magnification studies

 

Histologic dyes commonly used for amyloid plaque detection such as Congo Red or Thioflavin S or T come with a number of limitations, including their broad excitation frequencies which cause "bleed through" when using filters for other stains and the need for harsh chemicals during staining making them less compatible with the subsequent use of antibodies.

 

Amylo-Glo RTD (Cat. No. TR-300-AG) is a histological marker that shows clear superiority for visualising amyloid plaques over conventional markers with its... read more

 



Neuroscience - ImmunoStar
Immunostar neuroscience

 

Newmarket Scientific is the UK and Ireland Distributor of the ImmunoStar antibodies for neuroscience research. This set of antibodies was originally provided by DiaSorin (INCSTAR), before becoming ImmunoStar in 2001.

 

Having been available for many years this set of highly cited antibodies really has been tried and tested! Additionally ImmunoStar antibodies are put through extensive testing before release to ensure excellent reliability and lot-to-lot consistency.

 

Get further details of the full range of ImmunoStar antibodies for neuroscience research.

 



New antibody for Alzheimer’s research: Learn how the enzyme CYP46A1 controls brain cholesterol levels

 

Brain cholesterol is an important membrane building component of glial cells, neurons and myelin sheaths. Unable to cross the blood-brain-barrier, cholesterol is synthesised in situ, transported between the various cells and eliminated via oxidative pathways to maintain appropriate levels.

 

Key to regulating brain cholesterol homeostasis the CNS-specific cytochrome P450 enzyme, cholesterol 24-hydroxylase (CYP46A1) is mostly expressed in the brain, converting excess cholesterol to membrane-permeable 24HC (oxysterol, 24S-hydroxycholesterol). This oxidised product diffuses through the blood-brain-barrier entering the systemic circulation to reach the liver where it is degraded to bile acids. Accumulation of cholest... read more and find out about our CYP46A1 antibodies.

 



The role of retromer component VPS-35 in neurodegenerative diseases

 

Endosomes are important protein sorting stations contributing to cell homeostasis. Cargoes, originating from the plasma membrane or the biosynthesis pathways and entering the endosomal system, are either retained in endosomes for subsequent lysosomal degradation or exported from the endosomes for reuse or recycling. Deficiencies in the endosomal sorting system have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

 

Retromer is an evolutionarily conserved protein essential for the transport of transmembrane proteins from the endosomes back to the trans-Golgi network or to the plasma membrane via the recycling pathway. Retromer is a pentameric complex composed of a cargo-selective trimeric complex, with the major subunit being VPS-35 (vacuolar protein sorting 35)... read more and find out about our anti VPS35 antibodies.