Newmarket Scientific
Newmarket Scientific








Biosensis


Antibodies, kits and reagents for neuroscience research



Biosensis - fine bioscience tools

 

 

 

Biosensis specialises in antibodies and reagents for Neuroscience, with particular emphasis on neurotrophins and neurotrophin receptors. In addition to neurotrophins, the Biosensis neuroscience portfolio includes products for research in neurodegenerative diseases, neurodevelopment, and neuro-metabolism.

 

Areas of focus include Alzheimer's, Parkinson's and ALS diseases, as well as autophagy and metabolic and stress disorders including metabolic syndrome research, obesity, and neuroimmunology and inflammation.

 

The Biosensis’ range includes neuroscience research antibodies, more than 200 quantitative ELISA kits, tissue staining and cell visualization reagents, and purified proteins targeted for neuroscience and cellular disease research, many having been used in peer reviewed research publications.

 

Find your product using the search box above or if you have any questions please contact us as detailed on our contact and ordering page.

 



Biosensis α-synuclein RapidTM ELISA Kit
Alpha synuclein elisa and a

 

Alpha synuclein is an abundant 140 amino acid neuronal protein associated with a number of neurodegenerative diseases. Aggregated proteinaceous inclusions called Lewy bodies which are found in Parkinson's disease and cortical Lewy body dementia (LBD) have been shown to be predominantly alpha-synuclein.

 

Alpha-synuclein has also been detected in an increasing number of other neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein is therefore a key target in neurodegenerative disease research.

 

The Biosensis Alpha-Synuclein Rapid ELISA Kit (BEK-2216-1P/2P) lets you quantifiy human alpha-synuclein in plasma, serum and CSF, in under 4 hours with a high level of accuracy... read more about our Biosensis alpha-synuclein ELISA and antibodies.

 



Confidently measure mature BDNF

 

Brain-derived neurotrophic factor (BDNF) plays essential roles in the central nervous system regulating and supporting the growth, survival and differentiation of neurons. Brain insults or stress can cause variations in BDNF levels, which may contribute to depressive or neurological disorders such as epilepsy and Alzheimer’s disease.

 

To help researchers quantify BDNF, Biosensis have developed a robust ELISA for mature BDNF with high specificity that can be performed in less than 3 hours with high accuracy, sensitivity and reproducibility... read more and watch the video here.

 

Click for the Biosensis BDNF ELISA Tutorial

 



Why choose Biosensis sheep α-synuclein antibody?

 

Our Biosensis sheep anti alpha-synuclein antibodies offer a number of significant advantages over anti-α-synuclein antibodies raised in mouse and rabbit:

 

• Validated for multiple applications

• Perfect choice for rodent studies: avoiding cross-reactivity issues with mouse abs

• Optimal partner for mouse and rabbit antibodies in multi-labelling experiments

• Large batch sizes so no need to regularly re-validate as with rabbits antibodies

• Anti-goat secondary abs already in your freezer can be used for sheep primaries

 

Read more about the range of alpha-synuclein antibodies we have available.

 



Neurofilaments

 

Neurofilaments are a major constituent of the neuronal cytoskeleton and are composed principally of the neurofilament triplet proteins NF-L (light), NF-M (medium) and NF-H (heavy), but may also include peripherin, alpha-internexin, nestin and vimentin

 

Neurofilaments have a role in a variety of neurodegenerative diseases including multiple sclerosis and amyotrophic lateral sclerosis. They are also incorporated in the structure of intracellular Lewy bodies, in Parkinson’s Disease.

 

rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament     Rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2]     Read more about Neurofilaments

 



Nerve Growth Factor Receptor (p75NTR)

 

The nerve growth factor (NGF) receptor, also known as p75 neurotrophin receptor (p75NTR), is a low affinity NGF receptor. The other members of the neurotrophin family, including brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and NT-4/5 bind to p75NTR with equal affinity. This receptor also binds pro-neurotrophins. p75NTR mediates signalling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Altered neurotrophin levels and p75NTR expression are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS).

 

Our p75NTR antibody (clone 8J2) to the extracellular domain of p75NTR is ideal for:

 

- In vivo targeting: retrograde tracing and receptor trafficking

- Flow cytometry, immunopanning, western blot, immunohistochemistry and more.

- Most mammalian species, including human, mouse and rat

- Replacing clone MLR2 (A comparative study can be viewed here).

 

p75NTR antibody (clone 8J2)

 

Related products:

NGFR/p75ECD Rapid ELISA Kits (Human or Mouse),

Antibodies to p75NTR

NT3 Kits and Antibodies

NT4/5 Kits and Antibodies

 



Fluorescent dyes for for imaging sub-cellular structures

 

The Biosensis range of fluorescence imaging reagents is a superb set of tools for imaging polar lipids, endoplasmic reticulum, mitochondria, lipid-rich compartment imaging reagents.

 

These unique dyes are characterised by compatibility with other fluorescent dyes and antibodies, usability on live and fixed samples, excellent photo-stability, low cytotoxicity, large Stokes Shift, and rapid cellular uptake.

 

A complete product comparison is available here.

 

Comparison of Biosensis ER-O™  and ER-Tracker™

 

Above: Comparison of Biosensis ER-O™ Endoplasmic Reticulum Tracing Reagent (TR-601-ER1) with a competitor product (ER-Tracker™, a registered trademark of Invitrogen, upper panel). Merged image demonstrates identical staining patterns, but unlike ER-Tracker™, ER-O™ can be used to stain the endoplasmic reticulum in live and fixed tissues without any loss of signal (lower panel).