Product Search Results : AX17-10010


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Newmarket Scientific - NS Reagents AX17-10010 100ug £243.00
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Product Detail: Anti-TDP43 (Clone DB9)
Background Info: TAR DNA-binding protein 43 (TDP-43) has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. It belongs to the hnRNP protein family and is highly expressed in the pancreas, placenta, lung, genital tract and spleen.

Characterisation of transcriptome-wide binding sites revealed that thousands of RNAs are bound by TDP-43 in neurons. TDP-43 regulates alternate splicing of the CFTR gene. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.

Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.

Product Type: NS Reagents Antibody
Format: 100 µg in 100 µl PBS containing 0.02% sodium azide.
Storage Temp: 6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal: Mouse
Species Reactivity: Human
Immunogen: A His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
Applications: ELISA ¦ IHC ¦ WB
Alternative Name: TAR DNA-binding protein 43, TDP-43, transactive response DNA binding protein 43 kDa
Clone number: Clone DB9
Antibody Isotype: IgG1 kappa
Kappa: Kappa
Application Details: IHC: 1:50
Category: Primary Antibodies
References: Neumann M, Sampathu DM, Kwong LK, Truax AC, et al. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314 (5796): 130–3.

Strong MJ, Volkening K, Hammond R, et al. (2007). TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neuroscience. 35 (2): 320–7.

Kwong LK, Neumann M, Sampathu DM, et al. (2007). TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114 (1): 63–70.

Tremblay C, St-Amour I, Schneider J, et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 70 (9): 788–98.
Uniprot ID: Q9NYM4
Gene ID: 10888