Newmarket Scientific Product Search Results for CaMKII

Product Search Results: CaMKII
Num Products Matched:
Product Search Results: CaMKII	Num Products Matched: 2	2

Biosensis

R-1706-100

100 µL

£288.00

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Product Detail:	Rabbit anti-Phospho-calcium/calmodulin-dependent protein kinase type II subunit alpha, Thr253 (alpha-CaMKII, Thr253) Polyclonal Antibody (Unconjugated), suitable for WB.
Background Info:	Calcium/calmodulin-stimulated protein kinase II (CaMKII) is composed of four different chains (alpha, beta, gamma, and delta) and is abundantly expressed in neurons. CaMKII is involved in regulating many aspects of neuronal function, including neurotransmitter synthesis and release, modulation of ion channel activity and cellular transport. The enzymatic function of CaMKII is regulated by its multiple phosphorylation sites and targeting to sub-cellular locations through interactions with protein binding partners. Phosphorylation of Thr253 has been identified in vivo and found to alter the interaction of CaMKII with binding partners, but not change its enzymatic activity. Thus, phosphorylation of Thr253 is suggested to modulate functional responses based on its binding partner and subsequently its sub-cellular localization.
Product Type:	Antibody
Antibody Type:	Polyclonal
Format:	Lyophilized
Host Animal:	Rabbit
Species Reactivity:	Rat
Immunogen:	A synthetic peptide (NKmLpTINPSC) corresponding to the sequence around Thr253 (AA 249-257) in alpha-CaMKII was synthesized, purified to 95% purity by HPLC, analyzed by mass spectroscopy and coupled to diphtheria toxoid.
Applications:	WB
Antibody Isotype:	Mixed
Application Details:	Western Blotting (1:200 - 1:1000). Other applications have not been tested. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Biosensis Brand:	Biosensis®
Conjugate:	Unconjugated
Shelf Life:	12 months after date of receipt (unopened vial).
Use:	For research use only.
Product references:	Skelding KA et al (2012) J J Cereb Blood Flow Metab 32 (12), 2181-2192. Skelding KA et al (2010) Cell Signal 22 (5), 759-769. Gurd JW et al (2008) Brain Res 1218, 158-165. Migues PV et al (2006) J Neurochem 98 (1), 289-299.
Specificity:	Rat Predicted from gene analysis to react with human and mouse alpha-CaMKII.
Storage:	After reconstitution of lyophilized antibody, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
Purification:	Whole serum
Target:	Phospho-calcium/calmodulin-dependent protein kinase type II subunit alpha, Thr253 (alpha-CaMKII, Thr253)
Uniprot Number:	P11275

Nordic BioSite

EKX-GVCLL4-96

96T

£617.00

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Product Search Results: CaMKII

Product Search Results: CaMKII

Phospho-calcium/calmodulin-dependent protein kinase type II subunit alpha, Thr253 (alpha-CaMKII, Thr253), Rabbit Polyclonal Antibody-100 µL

Human CAMK2D(CaMKII delta) ELISA Kit