Monoclonal Anti-IDH1 (R132H) recognizes only the R132H mutation of human IDH1 (R132H) and does not cross react with other mutations. The most frequent known mutation (>90%) is the alteration of arginine to histidine (R132H).6. Hence, antibodies that recognize the IDH1R132H mutation can be useful for the diagnosis of mutation-bearing tumors like gliomas. Positive control Human Glioma tissue
Antibody Isotype:
IgG1k
Monosan Range:
MONOSAN
Clone:
Hmab-1
Concentration:
lot specific
Storage buffer:
Tissue culture supernatant with sodium azide
Storage:
2-8°C
References 1:
Capper et al. Pathol 2010;20(1):245-254
References 2:
Capper et al. Am J Surg Pathol 2010;34(8):1199-1204
The monoclonal antibody JC4 is specific for Cytotoxic necrotizing factor type 1 and the highly related Cytotoxic necrotizing factor type 2 (CNF1 and CNF2) of uropathogenic Escherichia coli. CNF1 and 2 belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal binding domain, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin. Monoclonal antibody JC4 recognizes an epitope between amino acids 169 to 191 of the N-terminal binding domain. JC4 neutralizes only CNF1.
The monoclonal antibody NG8 is specific for Cytotoxic necrotizing factor type 1 (CNF1) of uropathogenic Escherichia coli. CNF1 and CNF2 belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin. Monoclonal antibody NG8 recognizes an epitope between amino acids 704 and 730 of the C-terminal enzymatic domain. NG8 specifically neutralizes CNF1 while lacking activity for CNF2.
EBS-CD-42 reacts with CD86, a member of the immunoglobulin superfamily, and highly expressed on monocytes, dendritic cells and stimulated B-cells. It is probably the major CD28 ligand. Furthermore, EBS-CD-042 blocks binding of soluble CD152 to CD86.
Antibody Isotype:
IgG1-K
Monosan Range:
MONOSAN
Clone:
EBS-CD-042
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
Giguère JF et al, J Virol 78: 6222-32 (2004)
References 2:
Mauri D et al, J Immunol 155: 118-27 (1995)
References 3:
Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press (1995)
References 4:
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)
References 5:
Sandilands GP et al, Immunology 108: 329337 (2003)
CD59, or protectin, is a 18-22 kDa cell surface molecule on an GPI anchor. It regulates complementmediated cell lysis and is supposed to protect normal and tumor cells from cytotoxic attack by homologous complement through binding to C8 and C9. CD59 is expressed on leucocytes, vascular epithelium, a variety of epithelial cells and placenta. B-cell express low levels. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease Paroxysmal nocturnal hemoglobinuria (PNH). 193-27 Was typed at the VIth International Workshop on human leucocyte differentiation antigens.
Antibody Isotype:
IgM-K
Monosan Range:
MONOSAN
Clone:
193-27
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)
References 2:
Shichishima T. et al. Br J Haematol, 85(2):378-386 (1993)
References 3:
Navenot JM. et al. Transfusion 38(4):337-342 (1998)
References 4:
Murray EW et al, J Biol Chem, 273(39):25279-25284 (1998)
F4-29D9 reacts with CD55 or DAF (Decay Accelerating Factor). All leucocytes as well as human erythrocytes, fibroblasts, platelets, endothelial cells and neuroectodermal cells are positive for DAF. F4-29D9 also recognizes an antigen on spermatozoid cells. It is a glycosylphosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. CD55 also serves as receptor for CD97 and for echovirus and coxsackie B virus. DAF is deficient in both granulocytes and monocytes in patients with paroxysmal nocturnal haemoglobinuria.
Antibody Isotype:
IgG1-K
Monosan Range:
MONOSAN
Clone:
F4-29D9
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)
References 2:
B.E. Loveland - in Leucocyte Typing VI - Part 6 CD55 Workshop Panel Report pp519-520, (1997)
References 3:
Ruix-Delgado, GJ et al, Hematology 14: 33-7 (2009)
CD53 is a 33-55 kDa protein expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on B- and T-cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. 161-2 Partially inhibits T-cell proliferation induced by CD3 UCHT-1 antibody. 161-2 was typed in Kobe, Japan at the VIth International Workshop on human leucocyte differentiation antigens.
Antibody Isotype:
IgG2a-K
Monosan Range:
MONOSAN
Clone:
161-2
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)
203-6 Reacts with human CD27, a disulphide-linked 120 kDa dimer. CD27 is a lymphocyte-specific member of the TNF-R/NGF-R superfamily, and is expressed on a subset of human thymocytes and on the majority of mature T-lymphocytes. CD27 is highly expressed on activated T and B-cells. 203- 6 was clustered at the VIth WLDA.
Antibody Isotype:
IgG3-K
Monosan Range:
MONOSAN
Clone:
203-6
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)
Mouse anti Human CD200R antibody, clone OX108 recognizes human CD200R, a cell surface glycoprotein (also known as OX2R). In humans CD200R is expressed primarily by peripheral blood monocytes and neutrophils but also by other leucocytes including T-lymphocytes and mast cells, CD200-CD200R interaction may be involved in the control of myeloid cellular function (Wright et al. 2003). Levels of expression on resting peripheral blood cells are relatively low.
It recognizes a transmembrane glycoprotein of 95 kDa, identified as CD18 or intergrin-2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers. LFA-1, MAC-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54, ICCAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and IC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This Mab blocks these cellular interactions. 68-5A5 was clustered at the IIIrd International Workshop on human leucocyte differentiation antigens.
Antibody Isotype:
IgG2a-K
Monosan Range:
MONOSAN
Clone:
68-5A5
Concentration:
100 ug/ml
Storage buffer:
PBS with 0.02% sodium azide
Storage:
2-8°C
References 1:
McMichael A.J.et al., Leucocyte typing III, Oxford University Press, Oxford, (1987)
The antibody has a proven strong indirect immunofluorescent staining at a 1/400-1/600 dilution and a proven 4+ biotin-streptavidin/HRP staining at 1/1,000-1/1,200 dilution in rat globus pallidus and amygdala. Staining is completely eliminated by pretreatment with 100 µg of methionine enkephalin per mL of diluted antiserum. Pretreatment with 100 µg of leucine enkephalin only partially blocks staining.
FUM (Fumarase) Fumarate hydratase 1, mitochondrial (FUM1), Fumarate hydratase 2, cytosolic (FUM2) are enzymes which belong to a subpathway of tricarboxylic acid cycle, part of carbohydrate metabolism.
Product Type:
Antibody
Antibody Type:
Polyclonal
Format:
Lyophilized
Storage Temp:
The antibody may be stored at -20 °C for one year in its original formulation. Additionally, antibody may be stored at 2°Cto 8°Cfor up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.
Host Animal:
Rabbit
Species Reactivity:
Arabidopsis thaliana
Expected Species:
Ananas comosus, Capsicum chinense, Cynara cardunculus var. scolymus, Diplotaxis tenuifolia, Eruca versicaria, Genlisea aurea, Glycine soja, Gossypium hirsutum, Helianthus annuus, Hordeum vulgare, Nicotiana sylvestris, Nicotiana tabacum, Oryza sativa, Rhizophora mucronata, Ricinus communis, Solanum lycopersicum, Trifolium pratense, Zea mays, Vigna radiata, Quercus suberSpecies of your interest not listed? Contact us
Immunogen:
KLH-conjugated peptide chosen from Arabidopsis thaliana FUM protein sequence, mitochondrial (FUM1): P93033, TAIR: At2g47510, cytosolic (FUM2): UniProt Q9FI53, TAIR: At5g50950
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