Newmarket Scientific Product Search Results for 24274

Product Search Results: 24274
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Product Search Results: 24274	Num Products Matched: 2	2

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ImmunoStar

24274

100 uL

£273.00

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Product Detail:	5-HIAA (5-Hydroxyindoleacetic Acid) Antibody
Background Info:	Raised to 5-HIAA coupled to BSA with paraformaldehyde.
Product Type:	Antibody - Antibodies
Antibody Type:	polyclonal
Format:	Lyophilised
Host Animal:	Rabbit
Species Reactivity:	Rat, Sea Slug
Immunogen:	5-HIAA
Applications:	Immunohistochemistry, Immunocytochemistry, immunofluorescence
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	The 5-HIAA antibody was raised to 5-HIAA coupled to BSA with paraformaldehyde. The antibody produces moderate labeling of raphe neurons in normal rat. In rats whose serotonergic system has been activated, staining intensity is increased to a maximum label. Recommended dilutions of the antiserum are 1/200-1/400 for indirect immunofluorescence and 1/4000-1/8000 for biotin-streptavidin/HRP technique. The specificity of the antiserum was evaluated using a model system of gelatin-indole plugs by a method similar to published procedures (Schipper and Tilders, 1983). Results showed that the 5-HIAA antibody dose dependently stained 5-HIAA but did not stain any concentration of 5-HT or 5-HTP. The antiserum was also tested by pre-adsorption at 25 µg/mL with various BSA conjugates. While pre-adsorption with 5-HIAA conjugate completely eliminates immunolabeling, pre-adsorption with conjugates of 5-HT,5-HTP and dopamine had no effect on staining intensity or distribution of stain.
Gene Symbol:	SLC6A4
NCBI Gene Aliases:	5-HTT,5-HTTLPR,5HTT,HTT,OCD1,SERT,hSER
PubMed IDs:	16219029, 16110094, 2732954, 24657391

Monosan

MONX10697

1 ml

£718.00

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Product Detail:	Mouse anti-Cytokeratin 20, Clone K2 20.8 (monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	human
Immunogen:	Cytoskeletal preparation isolated from microdissected villi of human duodenal mucosa.
Applications:	IHC-P (1:50)
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.
Antibody Isotype:	IgG2a, kappa
Monosan Range:	MONXtra
Clone:	Ks20.8
Concentration:	Greater than or equal to 9,26 mg/L
Storage buffer:	PBS (pH 7.6) with 1% BSA and sodium azide
Storage:	2-8°C
References 1:	Botta MC et al. Pathologica. 2001; 93(6):640-644
References 2:	Leech SN et al. Journal of Clinical Pathology. 2001; 54:727-729
References 3:	Tan J et al. Human Pathology. 1998; 29(4):390-396
References 4:	Longatto Filho A et al. Acta Cytol. 1997; 41(4):961-971
References 5:	Moll R et al. American Journal of Pathology. 1992; 140(2):427-447

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