| Product Detail: |
CCK-8 (Cholecystokinin Octapeptide) Antibody |
| Background Info: |
Raised to sulphated CCK-8 (26-33) coupled to bovine thyroglobulin with glutaraldehyde. |
| Product Type: |
Antibody - Antibodies |
| Antibody Type: |
polyclonal |
| Format: |
Lyophilised |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Mouse, Rat |
| Immunogen: |
Sulfated CCK-8 (26-33) |
| Applications: |
Immunohistochemistry, Immunocytochemistry, immunofluorescence |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
The CCK-8 Antibody was raised to sulphated CCK-8 (26-33) coupled to bovine thyroglobulin with glutaraldehyde. The antibody has a proven strong indirect immunofluorescent staining at a 1/100-1/200 dilution and a strong Biotin-Streptavidin/HRP immunostaining at a 1/500-1/1000 dilution in rat hypothalamus and spinal cord. The specificity of the antiserum was examined by soluble pre-adsorption with the peptides in question at a final concentration of 10-6M CCK-8 immunolabeling was completely abolished by pre-adsorption with CCK-8, gastrin 17 and gastrin 34. Pre-adsorption with the following peptides resulted in no reduction of immunostaining: α-CGRP, -CGRP, neurotensin, somatostatin, substance P, leucine enkephalin, methionine enkephalin, VIP, neuropeptide Y, gastric inhibitory polypeptide, bombesin, glucagon, peptide YY, and FMRF amide. |
| PubMed IDs: |
1670782, 1479068, 1426962, 1423502, 1385495, 1381731, 1362106, 1283485, 1282325, 26264032 |
| Product category: |
Alzheimer's, Huntington's, Hypoxia, Inflammatory Bowel Disease, Neurobiology, Obesity, Transcription Factor, |
|
| Product Detail: |
Rabbit anti-CDK4, clone EP180 (Monoclonal) |
| Antibody Type: |
Monoclonal |
| Host Animal: |
Rabbit |
| Species Reactivity: |
human |
| Immunogen: |
a synthetic peptide corresponding to residues of human CDK4 protein |
| Applications: |
IHC-P (1:100-1:200) |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thrprotein kinase family. It is a catalytic subunit of the protein kinasecomplex that is important for cellcycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D- type cyclins and CDK inhibitor p16 (INK4a). Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression. |
| Antibody Isotype: |
IgG |
| Monosan Range: |
MONOSAN |
| Clone: |
EP180 |
| Concentration: |
n/a |
| Storage buffer: |
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage: |
2-8°C |
| References 1: |
Harbour JW, et al.: Cell 1999, 98:859-869 |
| References 2: |
Wikman H, et al.: Genes Chromosomes Cancer 2005, 42:193-199 |
| References 3: |
Poomsawat S, et al.: J Oral Pathol Med 2010, 39:793-799 |
| References 4: |
Lindberg D, et al.: Neuroendocrinology 2007, 86:112-118 |
| References 5: |
Wu A, et al.: J Transl Med 2011, 9:38 |
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