Newmarket Scientific Product Search Results for MDR1

Product Search Results: MDR1
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Monosan

MON9056

1 ml

£388.00

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Product Detail:	Mouse anti-MRP2 (ABCC2), clone M2III-5 (Monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	rat, mouse, human
Immunogen:	202-amino acid COOH terminal of rat Mrp2
Applications:	ICC, IHC-fr, IHC-P (1:20), WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	The antibody reacts with an internal epitope of MRP2, a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-5 was raised against a fusion protein of the bacterial maltose binding protein and rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein. The Mab detects rat, mouse and human MRP2. M2III-5 does not cross-react with the human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products.
Antibody Isotype:	IgG2b
Monosan Range:	MONOSAN
Clone:	M2III-5
Concentration:	250 ug/ ml
Storage buffer:	cell culture supernatant with 0.7% BSA and 0.1% sodium azide
Storage:	2-8°C
References 1:	Paulusma et al. Science 1996; 271: 1126-1128
References 2:	Kool et al. Cancer Res 1997; 57: 3537-3547
References 3:	Scheffer et al. Cancer Res 2000; 60: 5269-5277

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Product Search Results: MDR1

Product Search Results: MDR1

Mouse anti-MRP2 (ABCC2), clone M2III-5 (Monoclonal)