Search Results : SMC-122C Num PRODUCTS MATCHED : 1

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PSD95 Antibody StressMarq SMC-122C 25 µg £117.00
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Product Detail: PSD 95 Antibody, Clone 6G6
Background Info: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).
PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
Product Type: Antibodies
Format: PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp: -20ºC
Host Animal: Mouse
Species Reactivity: Hu | Ms | Rt | Bv
Immunogen: Recombinant rat PSD-95
Applications: WB | IHC | ICC/IF | AM
Clone number: 6G6
Antibody Isotype: IgG2a
Application Details: WB (1:250), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Target: PSD95
Conjugate: Unconjugated
Research Area(s): Neuroscience | Cell Structure | Post-Synaptic Markers | Cell Signaling | Organelle Markers
Alternative Name(s): PSD 95 Antibody, PSD-95 Antibody, DLG4 Antibody, SAP90 Antibody, Synapse-associated protein 90 Antibody, Postsynaptic density protein 95 Antibody, Disks large homolog 4 Antibody
Category: Monoclonal
Immunogen Species: Rat
Accession Number: NP_062567.1
Gene ID: 29495
Swiss-Prot: P31016
Species Reactivity Full Name: Human | Mouse | Rat | Bovine
Purification: Protein G Purified
Concentration: 1 mg/ml
Specificity: Detects ~100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples.
Shipping Temperature: Blue Ice or 4ºC
Certificate of Analysis: 1 µg/ml was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.
Cellular Localization: Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density | Cell Projection | Axon
References: 1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22(15): 6415-25.
2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168(1): 117-26.
3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268.
4. Irie M. et al. (1997) Science 277(5331): 1511-5.
5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73.
6. Yao W.D. et al. (2004) Neuron 41: 625-38.
7. Cline H. (2005) Curr Biol. 15: R203-5.
Launch Date: 1-Nov-2007
Tarriff Code: 3002.10.0290
ADR Code: Non-hazardous
UN Code for transport: Non-hazardous
Country of Origin: Canada