Newmarket Scientific Product Search Results for 20092

Product Search Results: 20092
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Product Search Results: 20092	Num Products Matched: 2	2

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Monosan

MON2032

1 ml

£501.00

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Product Detail:	Mouse anti-Alpha v Beta Integrin, clone BV3 (Monoclonal)
Antibody Type:	Monoclonal
Host Animal:	Mouse
Species Reactivity:	human, chicken, rat
Immunogen:	Unknown or proprietery to MONOSAN and/or its suppliers
Applications:	FC,ELISA,IF,IP,IHC-P
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	The monoclonal antibody BV3 recognizes human alpha-V/beta-3 integrin present on human cells. Integrins are a superfamily of ?Î² heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The Î²3 family consist of 2 members: ?IIbÎ²3 and ?vÎ²3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin ?vÎ²3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin ?vÎ²3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of Î²3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin ?vÎ²3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin ?vÎ²3 has been demonstrated in various tumors and activated endothelium.
Antibody Isotype:	IgG1
Monosan Range:	MONOSAN
Clone:	BV3
Concentration:	100 ug/ ml
Storage buffer:	PBS with 0.1% BSA and 0.02% sodium azide
Storage:	2-8°C
References 1:	Newton; S et al. Eur J neurosc 2006; 24:819-828
References 2:	Merkel, O et al Bioconj chem 2009, 20:1270-1280
References 3:	Dare; E et al. Tissue engineering; 2009; 15:2285

ImmunoStar

20092

100 uL

£374.00

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Product Detail:	Vesicular Inhibitory Amino Acid Transporter (VIAAT) Rabbit Antibody
Background Info:	Vesicular Inhibitory Amino Acid Transporter (VIAAT) Rabbit Antibody - Demonstrates excellent positive labeling and very low background.
Product Type:	Antibody - Antibodies
Antibody Type:	polyclonal
Format:	Lyophilised Whole Serum
Host Animal:	Rabbit
Species Reactivity:	Rat
Expected Species:	100% sequence homology with rat, mouse and human
Immunogen:	Synthetic peptide corresponding to rat VIAAT 511-525 coupled to carrier protein.
Applications:	Immunohistochemistry
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Alternative Name:	Vesicular Inhibitory Amino Acid Transporter
Additional Info:	The ImmunoStar VIAAT antiserum was quality control tested using standard immunohistochemical methods in rat brain and spinal cord using biotin/avidin-HRP techniques.Specificity of the antiserum was demonstrated by soluble pre-adsorption and Western blot. Tissue staining is completely eliminated by pretreatment of the diluted antibody with an excess of rat VIAAT peptide residues 511-525. Western blot analysis of immunoprecipitated rat brain homogenates demonstrates a dense immunoreactive band of approximately 57 kD and a minor band of approximately 36 kD.
Gene Symbol:	Slc32a1
NCBI Gene Aliases:	Vgat,Viaa

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