| Product Detail: |
Anti-Nogo Antibody (Polyclonal) |
| Background Info: |
Nogo (Reticulon-4) exists in 3 isoforms (Nogo-A, Nogo-B, and Nogo-C) that share a C-terminal domain of 188 amino acid residues, known as the highly conserved reticulon homology domain. It was originally identified as an inhibitor of neurite outgrowth and axonal regeneration in the central nervous system [1]
Nogo-A (the largest isoform) is a neurite outgrowth inhibitor and is mainly secreted in the central nervous system. Nogo-B is expressed in tissues including vessel walls, smooth muscles, skeletal muscles, and endothelium, and Nogo-C is secreted in the liver, vascular smooth muscles, skeletal muscles, heart, and neurons.
This antibody binds all 3 isoforms.
|
| Product Type: |
NS Reagents Antibody |
| Antibody Type: |
Polyclonal Antibody |
| Format: |
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| Storage Temp: |
Store at -20?. Avoid freeze / thaw cycles. |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Human Mouse Rat |
| Immunogen: |
A synthetic peptide of human RTN4 |
| Applications: |
WB IHC |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you. |
| Antibody Isotype: |
IgG |
| Application Details: |
WB 1:500-2000. IHC 1:50-200. |
| Antibody Number: |
10127 |
| Category: |
Primary Antibodies |
| Other names: |
Reticulon-4, RTN4, ASY, NSP, NOGO, NOGOC, RTN-X, Nogo-A, NSP-CL, Nogo-B, Nogo-C, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein C homolog |
| Research Areas: |
Neuroscience |
| NS Reagents Product Area: |
Neuroscience |
| Molecular Weight: |
129 kDa (Intended as a general guide and does not allow for all isoforms and species variations) |
| Subcellular location: |
Endoplasmic reticulum (membrane), Plasma membrane |
| Purification: |
Affinity purification |
| References: |
[1] Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434439. |
| Uniprot ID: |
Q9NQC3 |
| Gene ID: |
57142 |
| Gene symbol: |
RTN4 |
| Release Date: |
Feb-20 |
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