CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human
Expected Species:
Mouse, Rat, Dog, Goat, Sheep, Bovine, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Antibody Number:
10100
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human
Expected Species:
Mouse, Rat, Dog, Goat, Sheep, Bovine, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Antibody Number:
10100
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
Uniprot ID:
Q9Y5K6
Gene ID:
23607
Gene symbol:
CD2AP
Release Date:
May-19
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.