CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human
Expected Species:
Mouse, Rat, Dog, Goat, Sheep, Bovine, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Antibody Number:
10100
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human
Expected Species:
Mouse, Rat, Dog, Goat, Sheep, Bovine, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Antibody Number:
10100
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
Uniprot ID:
Q9Y5K6
Gene ID:
23607
Gene symbol:
CD2AP
Release Date:
May-19
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