| Product Detail: |
Anti-TUSC2 Antibody (Polyclonal) |
| Background Info: |
Tumor suppressor candidate 2 (TUSC2) is known to act as a tumor-suppressor and reduced expression of TUSC2 is seen in specific cancers across a number of different tissues. TUSC2 is a target for many microRNAs (miRNAs) that act as modulators of tumorigenesis and tumor progression. In glioblastoma (and possibly in other cancers) TUSC2 acts by up-regulating the level of miR-197 [1]. In Triple Negative Breast Cancer (TNBC) the TUSC2 gene is silenced by miR-138 binding to a unique 5?-UTR target-site, which overlaps with the translation start-site of the transcript. In ovarian cancer miR-663 acts as a potential tumor-promoting miRN through targeting TUSC2.
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| Product Type: |
NS Reagents Antibody |
| Antibody Type: |
Polyclonal |
| Format: |
100 µg in 100 µl PBS containing 0.02% sodium azide. |
| Storage Temp: |
6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles. |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Human, Mouse, Rat |
| Expected Species: |
Cat, Gunea Pig, Horse, Golden Hamster
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you. |
| Immunogen: |
Full length recombinant human TUSC2 |
| Applications: |
WB IHC IF |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you. |
| Antibody Isotype: |
IgG |
| Application Details: |
WB 1:500-2000. IHC 1:50-200. IF 1:50-100. |
| Antibody Number: |
10075 |
| Category: |
Primary Antibodies |
| Other names: |
C3orf11, FUS1, PAP, PDAP2, Tumor suppressor candidate 2,Tumor Suppressor 2, Mitochondrial Calcium Regulator, Tumor Suppressor Candidate, PDGFA-Associated Protein, Fusion 1 Protein, Fus-1 Protein |
| Research Areas: |
DNA & Protein Modification, Cancer |
| NS Reagents Product Area: |
DNA & Protein Modification |
| Molecular Weight: |
12kDa (Intended as a general guide and does not allow for all isoforms and species variations) |
| Subcellular location: |
Mitochondrion |
| Purification: |
Affinity purification |
| References: |
1. Xin J, Zhang XK, Xin DY, Li XF, Sun DK, Ma YY, Tian LQ. FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma. Oncol Rep. 2015;34(2):86876. |
| Uniprot ID: |
O75896 |
| Gene ID: |
11334 |
| Gene symbol: |
TUSC2 |
| Release Date: |
Jan-19 |
