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Product Search Results: AA17-10048

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Product Search Results: AA17-10048

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Newmarket Scientific - NS Reagents AA17-10048-50ul 50 µl £258.00
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Product Detail: Anti-Daxx Antibody (Polyclonal - Sera)
Background Info: Death-domain-associated protein (DAXX) is a transcription regulator, that interacts with proteins involved in transcriptional silencing, such as histone deacetylases (HDAC1 and HDAC2) and DNA methyltransferase DNMT1. It represses the activity of several transcriptional factors, including C/EBP beta, c-Met, Pax3, Ets1, p53, p73, p63, glucocorticoid receptor, androgen receptor, and SMAD4.

DAXX is a nuclear protein associated with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains. It can be either a pro-apoptotic or an anti-apoptotic factor, depending on the cell type and context. Daxx is thought to play a role in the pathology of human diseases including cancer and neurodegenerative disorders.
Product Type: NS Reagents Antibody
Antibody Type: Polyclonal
Format: Sera with Sodium Azide
Storage Temp: 6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal: Rabbit
Species Reactivity: Bovine, Dog, Human, Monkey, Rat, Dog, Cat, Pig, Sheep, Rabbit, Guinea pig
Expected Species: Mouse (single amino acid difference with the immunogen/human peptide sequence).

If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen: A synthetic peptide from the central region of Human Daxx
Applications: IP ¦ IHC ¦ WB
Data Sheet: PLEASE CLICK HERE TO DOWNLOAD
Additional Info: If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype: IgG
Application Details: WB: 1:1000-1:2000
IHC (paraffin): 1:1000-1:5000
IHC (frozen): 1:1000-1:2000
IP: 1:50-1:200
Antibody Number: 10048
Category: Primary Antibodies
Other names: DAXX, DAP6, Death domain-associated protein 6, Fas-binding protein, ETS1-associated protein 1
Research Areas: Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification
NS Reagents Product Area: DNA & Protein Modification
Molecular Weight: 82kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location: Nucleoplasm, PML body, nucleolus, cytoplasm, centromere
Purification: Sera
Uniprot ID: Q9UER7
Gene ID: 1616
Gene symbol: DAXX
Release Date: Dec-17