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8-Hydroxyguanosine | DNA/RNA oxidative damage (25 µg) Agrisera AS10 708-25 25 µg £237.00
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Background Info: Oxidative derivate of guanosine is called 8-Hydroxyguanosine (8OHdG) and is used as a popular biomarker of oxidative stress.
Product Type: Antibody
Antibody Type: Monoclonal
Storage Temp: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Host Animal: Mouse
Species Reactivity: Recognizes markers of oxidative damage to DNA (8-hydroxy-2’-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine)
Immunogen: 8-hydroxy-guanosine-BSA and – casein conjugates
Applications: ELISA (ELISA), Immunoaffinity chromatography (IAP), Immunohistochemistry on frozen tissue and paraffin-embedded (IHC-Fr-P)
Additional Info: Protocol for immunostaining using this antibody can be found here.
Application Details: The optimal working dilution should be determined by the investigator.
Clone number: IgG2A (clone 15A3)
Purity: Protein G purified
Format: Liquid
Related products: AS10 708-100 | hydroxy guanosine monoclonal antibody, 100 µgSecondary antibodies
Not reactive in: No confirmed exceptions from predicted reactivity are currently known.
Selected references: Haigh and Drew (2015). Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation? Biochem Biophys Res Commun. 2015 Apr 17. pii: S0006-291X(15)00726-3. doi: 10.1016/j.bbrc.2015.04.048. Poborilova et al. (2015). DNA hypomethylation concomitant with the overproduction of ROS induced by naphthoquinone juglone on tobacco BY-2 suspension cells. Environmental and Experimental Botany, Volume 113, May 2015, Pages 28–39.
Special application note: Protein G purified IgG2B in PBS, pH 7.4 with 0.09 % sodium azide and 50 % glycerol at concentration 0.65 mg/ml.