Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
Applications:
WB | IHC | ICC/IF | AM
Clone number:
S25-35
Antibody Isotype:
IgG1
Application Details:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 390-445 of human Kir2.3
IRK3 Antibody, HIR Antibody, HIRK2 Antibody, HRK1 Antibody, KCNJ4 Antibody, potassium inwardly rectifying channel subfamily J member 4 Antibody
Category:
Monoclonal
Immunogen Species:
Human
Accession Number:
NP_004972.1
Gene ID:
3761
Swiss-Prot:
P48050
Species Reactivity Full Name:
Human | Mouse | Rat
Purification:
Protein G Purified
Concentration:
1 mg/ml
Specificity:
Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Certificate of Analysis:
1 µg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Cytoplasmic Vesicle Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Applications:
WB | IHC | ICC/IF
Clone number:
S366-60
Antibody Isotype:
IgG2A
Application Details:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Target:
Kir6.1
Conjugate:
Unconjugated
Research Area(s):
Neuroscience | Ion channels | Potassium Channels | Inward-Rectifying Potassium Channels | Cancer
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Product Type:
Antibodies
Format:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage Temp:
-20ºC
Host Animal:
Mouse
Species Reactivity:
Hu | Ms | Rt
Immunogen:
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization:
Membrane
References:
1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
Tarriff Code:
3002.15.0000
ADR Code:
Non-hazardous
UN Code for transport:
Non-hazardous
Country of Origin:
Canada
Cookies:
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