Newmarket Scientific Product Search Results for AX17-10013

Product Search Results: AX17-10013
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Product Search Results: AX17-10013	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AX17-10013-100ug

100 µg

275

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Product Detail:	Anti-ANO5 (Clone 5F7)
Background Info:	Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible. Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies. ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	100 µg in 100 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human, Mouse, Rat
Expected Species:	Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from the C-terminal region of Human ANO5
Applications:	IF ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone 5F7
Antibody Isotype:	IgM
Category:	Primary Antibodies
Other names:	Anoctamin-5, ANO5
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Peptide Sequence (Internal Use only):	KREKLMTIKILHDFE (AA 866-880) Full length protein is 913 aa in length 10 20 30 40 50 MGDPDLLEVL AEEGEKVNKH IDYSFQMSEQ SLSSRETSFL INEETMPAKR 60 70 80 90 100 FNLFLRRRLM FQKNQQSKDS IFFRDGIRQI DFVLSYVDDV KKDAELKAER 110 120 130 140 150 RKEFETNLRK TGLELEIEDK RDSEDGRTYF VKIHAPWEVL VTYAEVLGIK 160 170 180 190 200 MPIKESDIPR PKHTPISYVL GPVRLPLSVK YPHPEYFTAQ FSRHRQELFL 210 220 230 240 250 IEDQATFFPS SSRNRIVYYI LSRCPFGIED GKKRFGIERL LNSNTYSSAY 260 270 280 290 300 PLHDGQYWKP SEPPNPTNER YTLHQNWARF SYFYKEQPLD LIKNYYGEKI 310 320 330 340 350 GIYFVFLGFY TEMLFFAAVV GLACFIYGLL SMEHNTSSTE ICDPEIGGQM 360 370 380 390 400 IMCPLCDQVC DYWRLNSTCL ASKFSHLFDN ESTVFFAIFM GIWVTLFLEF 410 420 430 440 450 WKQRQARLEY EWDLVDFEEE QQQLQLRPEF EAMCKHRKLN AVTKEMEPYM 460 470 480 490 500 PLYTRIPWYF LSGATVTLWM SLVVTSMVAV IVYRLSVFAT FASFMESDAS 510 520 530 540 550 LKQVKSFLTP QITTSLTGSC LNFIVILILN FFYEKISAWI TKMEIPRTYQ 560 570 580 590 600 EYESSLTLKM FLFQFVNFYS SCFYVAFFKG KFVGYPGKYT YLFNEWRSEE 610 620 630 640 650 CDPGGCLIEL TTQLTIIMTG KQIFGNIKEA IYPLALNWWR RRKARTNSEK 660 670 680 690 700 LYSRWEQDHD LESFGPLGLF YEYLETVTQF GFVTLFVASF PLAPLLALIN 710 720 730 740 750 NIVEIRVDAW KLTTQYRRTV ASKAHSIGVW QDILYGMAVL SVATNAFIVA 760 770 780 790 800 FTSDIIPRLV YYYAYSTNAT QPMTGYVNNS LSVFLIADFP NHTAPSEKRD 810 820 830 840 850 FITCRYRDYR YPPDDENKYF HNMQFWHVLA AKMTFIIVME HVVFLVKFLL 860 870 880 890 900 AWMIPDVPKD VVERIKREKL MTIKILHDFE LNKLKENLGI NSNEFAKHVM 910 IEENKAQLAK STL
Molecular Weight:	37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cell membrane, Endoplasmic reticulum membrane
Purification:	Affinity Purified
References:	Bashir et al. 2014. Neuromuscular Disorders. 24:1
Uniprot ID:	Q75V66
Gene ID:	203859
Gene symbol:	ANO5
Release Date:	October 2017

Newmarket Scientific - NS Reagents

AX17-10013-50ug

50 µg

220

Please sign in or sign up to order this product online.

Product Detail:	Anti-ANO5 (Clone 5F7)
Background Info:	Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible. Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies. ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	50 µg in 50 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human, Mouse, Rat
Expected Species:	Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from the C-terminal region of Human ANO5
Applications:	IF ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone 5F7
Antibody Isotype:	IgM
Category:	Primary Antibodies
Other names:	Anoctamin-5, ANO5
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Peptide Sequence (Internal Use only):	KREKLMTIKILHDFE (AA 866-880) Full length protein is 913 aa in length 10 20 30 40 50 MGDPDLLEVL AEEGEKVNKH IDYSFQMSEQ SLSSRETSFL INEETMPAKR 60 70 80 90 100 FNLFLRRRLM FQKNQQSKDS IFFRDGIRQI DFVLSYVDDV KKDAELKAER 110 120 130 140 150 RKEFETNLRK TGLELEIEDK RDSEDGRTYF VKIHAPWEVL VTYAEVLGIK 160 170 180 190 200 MPIKESDIPR PKHTPISYVL GPVRLPLSVK YPHPEYFTAQ FSRHRQELFL 210 220 230 240 250 IEDQATFFPS SSRNRIVYYI LSRCPFGIED GKKRFGIERL LNSNTYSSAY 260 270 280 290 300 PLHDGQYWKP SEPPNPTNER YTLHQNWARF SYFYKEQPLD LIKNYYGEKI 310 320 330 340 350 GIYFVFLGFY TEMLFFAAVV GLACFIYGLL SMEHNTSSTE ICDPEIGGQM 360 370 380 390 400 IMCPLCDQVC DYWRLNSTCL ASKFSHLFDN ESTVFFAIFM GIWVTLFLEF 410 420 430 440 450 WKQRQARLEY EWDLVDFEEE QQQLQLRPEF EAMCKHRKLN AVTKEMEPYM 460 470 480 490 500 PLYTRIPWYF LSGATVTLWM SLVVTSMVAV IVYRLSVFAT FASFMESDAS 510 520 530 540 550 LKQVKSFLTP QITTSLTGSC LNFIVILILN FFYEKISAWI TKMEIPRTYQ 560 570 580 590 600 EYESSLTLKM FLFQFVNFYS SCFYVAFFKG KFVGYPGKYT YLFNEWRSEE 610 620 630 640 650 CDPGGCLIEL TTQLTIIMTG KQIFGNIKEA IYPLALNWWR RRKARTNSEK 660 670 680 690 700 LYSRWEQDHD LESFGPLGLF YEYLETVTQF GFVTLFVASF PLAPLLALIN 710 720 730 740 750 NIVEIRVDAW KLTTQYRRTV ASKAHSIGVW QDILYGMAVL SVATNAFIVA 760 770 780 790 800 FTSDIIPRLV YYYAYSTNAT QPMTGYVNNS LSVFLIADFP NHTAPSEKRD 810 820 830 840 850 FITCRYRDYR YPPDDENKYF HNMQFWHVLA AKMTFIIVME HVVFLVKFLL 860 870 880 890 900 AWMIPDVPKD VVERIKREKL MTIKILHDFE LNKLKENLGI NSNEFAKHVM 910 IEENKAQLAK STL
Molecular Weight:	37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cell membrane, Endoplasmic reticulum membrane
Purification:	Affinity Purified
References:	Bashir et al. 2014. Neuromuscular Disorders. 24:1
Uniprot ID:	Q75V66
Gene ID:	203859
Gene symbol:	ANO5
Release Date:	October 2017

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Product Search Results: AX17-10013

Product Search Results: AX17-10013

Anti-Anoctamin-5 Antibody

Anti-Anoctamin-5 Antibody