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Product Search Results: AB20-10127

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Product Search Results: AB20-10127

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Newmarket Scientific - NS Reagents AB20-10127-50ug 50 µg £220.00
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Product Detail: Anti-Nogo Antibody (Polyclonal)
Background Info: Nogo (Reticulon-4) exists in 3 isoforms (Nogo-A, Nogo-B, and Nogo-C) that share a C-terminal domain of 188 amino acid residues, known as the highly conserved reticulon homology domain. It was originally identified as an inhibitor of neurite outgrowth and axonal regeneration in the central nervous system [1]

Nogo-A (the largest isoform) is a neurite outgrowth inhibitor and is mainly secreted in the central nervous system. Nogo-B is expressed in tissues including vessel walls, smooth muscles, skeletal muscles, and endothelium, and Nogo-C is secreted in the liver, vascular smooth muscles, skeletal muscles, heart, and neurons.

This antibody binds all 3 isoforms.

Product Type: NS Reagents Antibody
Antibody Type: Polyclonal Antibody
Format: 50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp: Store at -20?. Avoid freeze / thaw cycles.
Host Animal: Rabbit
Species Reactivity: Human Mouse Rat
Immunogen: A synthetic peptide of human RTN4
Applications: WB IHC
Data Sheet: PLEASE CLICK HERE TO DOWNLOAD
Additional Info: If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype: IgG
Application Details: WB 1:500-2000. IHC 1:50-200.
Antibody Number: 10127
Category: Primary Antibodies
Other names: Reticulon-4, RTN4, ASY, NSP, NOGO, NOGOC, RTN-X, Nogo-A, NSP-CL, Nogo-B, Nogo-C, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein C homolog
Research Areas: Neuroscience
NS Reagents Product Area: Neuroscience
Molecular Weight: 129 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location: Endoplasmic reticulum (membrane), Plasma membrane
Purification: Affinity purification
References: [1] Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434–439.
Uniprot ID: Q9NQC3
Gene ID: 57142
Gene symbol: RTN4
Release Date: Feb-20