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Product Search Results: clone GrB-7

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Product Search Results: clone GrB-7

Num Products Matched: 1 1

Product - please click for more details Brand Cat No Size ▲ Price (£)

Monosan MON7029C 1 ml £408.00
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Product Detail: Mouse anti-Granzyme B, clone GrB-7 (Monoclonal)
Antibody Type: Monoclonal
Host Animal: Mouse
Species Reactivity: human
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Applications: ICC, ELISA, IHC-P
Data Sheet: PLEASE CLICK HERE TO DOWNLOAD
Additional Info: The antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.
Antibody Isotype: IgG2a
Monosan Range: MONOSAN
Clone: GrB-7
Concentration: 100 ug/ ml
Format: Protein G purified
Storage buffer: PBS with 0.1% BSA and 0.1% sodium azide
Storage: 2-8°C
References 1: Kummer, J.A et al. J. Immunol. Methods 1993; 163: 77
References 2: Kummer, J.A et al.Clin. Exp. Immunol. 1995;100: 164
References 3: de Bruin, P.C. et al. Blood 1994; 84: 3785-3791
References 4: Oudejans, J.J et al.Am. J. Pathology 1996; 148: 233-240
References 5: Oudejans, J.J et al. Blood 1996; 87: 3844-3851