Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
Uniprot ID:
Q99527
Gene ID:
2852
Gene symbol:
GPER1
Release Date:
Dec-18
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