Newmarket Scientific Product Search Results for AX17-10003

Product Search Results: AX17-10003
Num Products Matched:
Product Search Results: AX17-10003	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AX17-10003-50ug

50 µg

£220.00

Please sign in or sign up to order this product online.

Product Detail:	Anti-WNK1 (Clone M42-P3B10)
Background Info:	WNK1 is a cytoplasmic serine-threonine kinase involved in the regulation of electrolyte homeostasis, cell signalling, survival, and proliferation. It is part of the ERK5 MAP kinase pathway and acts as an activator of sodium-coupled chloride cotransporters such as SCNN1A, SCNN1B, SCNN1D and SGK1 and as an inhibitor of WNK4 by phosphorylation or through an interaction with the WNK1 autoinhibitory domain. WNK1 may also play a role in actin cytoskeletal reorganisation. Defects in WNK1 are a cause of Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II - PHAII) an autosomal dominant disease characterised by severe hypertension and sensory and autonomic neuropathy type 2A (HSAN2A), a form of congenital sensory and autonomic neuropathy. Homologs of this WNK1 have been found in Arabidopsis thaliana, C. elegans, Chlamydomonas reinhardtii and Vitis vinifera as well as in vertebrates including Danio rerio and Taeniopygia guttata. This antibody was validated with HEK 293T cell lysate and HeLa cell lysate (1 in 1000 in 5% BSA)
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	50 µg in 50 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human
Expected Species:	Mouse , Rat, Chicken, Duck, Hamster, Goat, Sheep, Cow, Dog, Cat, Pig and Horse. If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from the C-terminal region of Human WNK1 - Ovalbumin Conjugated (The selected sequence is highly conserved across many species).
Applications:	ELISA ¦ IHC ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone M42-P3B10
Antibody Isotype:	IgG1 kappa
Application Details:	WB 1:1000 in 5% BSA, IHC 1:50-1:500
Category:	Primary Antibodies
Other names:	WNK1, Erythrocyte 65 kDa protein, Human Accelerated Region 5, WNK Lysine Deficient Protein Kinase 1, hWNK1
Research Areas:	Cell Signalling, Neuroscience
NS Reagents Product Area:	Cell Signalling
Peptide Sequence (Internal Use only):	Peptide sequence (KSISNPPGSN) aa 2369-2378 The immunogen peptide was selected from the C-terminal region of Human WNK1. The sequence is highly conserved across many species including mouse, rat, chicken, duck, hamster, goat, sheep, cow, dog, pig and horse. Full length protein is 2382 aa in length 10 20 30 40 50 MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR 60 70 80 90 100 TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL 110 120 130 140 150 SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG 160 170 180 190 200 PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ 210 220 230 240 250 QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 260 270 280 290 300 ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 310 320 330 340 350 TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 360 370 380 390 400 KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 410 420 430 440 450 ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 460 470 480 490 500 EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 510 520 530 540 550 KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 560 570 580 590 600 HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSLK QQVEQSSASQ 610 620 630 640 650 TGIKQLPSAS TGIPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL 660 670 680 690 700 SDGTVDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTV PGHIPSTVQA 710 720 730 740 750 QSQPHGVYPP SSVAQGQSQG QPSSSSLTGV SSSQPIQHPQ QQQGIQQTAP 760 770 780 790 800 PQQTVQYSLS QTSTSSEATT AQPVSQPQAP QVLPQVSAGK QLPVSQPVPT 810 820 830 840 850 IQGEPQIPVA TQPSVVPVHS GAHFLPVGQP LPTPLLPQYP VSQIPISTPH 860 870 880 890 900 VSTAQTGFSS LPITMAAGIT QPLLTLASSA TTAAIPGVST VVPSQLPTLL 910 920 930 940 950 QPVTQLPSQV HPQLLQPAVQ SMGIPANLGQ AAEVPLSSGD VLYQGFPPRL 960 970 980 990 1000 PPQYPGDSNI APSSNVASVC IHSTVLSPPM PTEVLATPGY FPTVVQPYVE 1010 1020 1030 1040 1050 SNLLVPMGGV GGQVQVSQPG GSLAQAPTTS SQQAVLESTQ GVSQVAPAEP 1060 1070 1080 1090 1100 VAVAQTQATQ PTTLASSVDS AHSDVASGMS DGNENVPSSS GRHEGRTTKR 1110 1120 1130 1140 1150 HYRKSVRSRS RHEKTSRPKL RILNVSNKGD RVVECQLETH NRKMVTFKFD 1160 1170 1180 1190 1200 LDGDNPEEIA TIMVNNDFIL AIERESFVDQ VREIIEKADE MLSEDVSVEP 1210 1220 1230 1240 1250 EGDQGLESLQ GKDDYGFSGS QKLEGEFKQP IPASSMPQQI GIPTSSLTQV 1260 1270 1280 1290 1300 VHSAGRRFIV SPVPESRLRE SKVFPSEITD TVAASTAQSP GMNLSHSASS 1310 1320 1330 1340 1350 LSLQQAFSEL RRAQMTEGPN TAPPNFSHTG PTFPVVPPFL SSIAGVPTTA 1360 1370 1380 1390 1400 AATAPVPATS SPPNDISTSV IQSEVTVPTE EGIAGVATST GVVTSGGLPI 1410 1420 1430 1440 1450 PPVSESPVLS SVVSSITIPA VVSISTTSPS LQVPTSTSEI VVSSTALYPS 1460 1470 1480 1490 1500 VTVSATSASA GGSTATPGPK PPAVVSQQAA GSTTVGATLT SVSTTTSFPS 1510 1520 1530 1540 1550 TASQLCIQLS SSTSTPTLAE TVVVSAHSLD KTSHSSTTGL AFSLSAPSSS 1560 1570 1580 1590 1600 SSPGAGVSSY ISQPGGLHPL VIPSVIASTP ILPQAAGPTS TPLLPQVPSI 1610 1620 1630 1640 1650 PPLVQPVANV PAVQQTLIHS QPQPALLPNQ PHTHCPEVDS DTQPKAPGID 1660 1670 1680 1690 1700 DIKTLEEKLR SLFSEHSSSG AQHASVSLET SLVIESTVTP GIPTTAVAPS 1710 1720 1730 1740 1750 KLLTSTTSTC LPPTNLPLGT VALPVTPVVT PGQVSTPVST TTSGVKPGTA 1760 1770 1780 1790 1800 PSKPPLTKAP VLPVGTELPA GTLPSEQLPP FPGPSLTQSQ QPLEDLDAQL 1810 1820 1830 1840 1850 RRTLSPEMIT VTSAVGPVSM AAPTAITEAG TQPQKGVSQV KEGPVLATSS 1860 1870 1880 1890 1900 GAGVFKMGRF QVSVAADGAQ KEGKNKSEDA KSVHFESSTS ESSVLSSSSP 1910 1920 1930 1940 1950 ESTLVKPEPN GITIPGISSD VPESAHKTTA SEAKSDTGQP TKVGRFQVTT 1960 1970 1980 1990 2000 TANKVGRFSV SKTEDKITDT KKEGPVASPP FMDLEQAVLP AVIPKKEKPE 2010 2020 2030 2040 2050 LSEPSHLNGP SSDPEAAFLS RDVDDGSGSP HSPHQLSSKS LPSQNLSQSL 2060 2070 2080 2090 2100 SNSFNSSYMS SDNESDIEDE DLKLELRRLR DKHLKEIQDL QSRQKHEIES 2110 2120 2130 2140 2150 LYTKLGKVPP AVIIPPAAPL SGRRRRPTKS KGSKSSRSSS LGNKSPQLSG 2160 2170 2180 2190 2200 NLSGQSAASV LHPQQTLHPP GNIPESGQNQ LLQPLKPSPS SDNLYSAFTS 2210 2220 2230 2240 2250 DGAISVPSLS APGQGTSSTN TVGATVNSQA AQAQPPAMTS SRKGTFTDDL 2260 2270 2280 2290 2300 HKLVDNWARD AMNLSGRRGS KGHMNYEGPG MARKFSAPGQ LCISMTSNLG 2310 2320 2330 2340 2350 GSAPISAASA TSLGHFTKSM CPPQQYGFPA TPFGAQWSGT GGPAPQPLGQ 2360 2370 2380 FQPVGTASLQ NFNISNLQKS ISNPPGSNLR TT
Molecular Weight:	65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cytoplasm
Purification:	Protein A Affinity Purified
Uniprot ID:	Q9H4A3
Gene ID:	65125
Gene symbol:	WNK1
Release Date:	October 2017

Newmarket Scientific - NS Reagents

AX17-10003-100ug

100 µg

£275.00

Please sign in or sign up to order this product online.

Product Detail:	Anti-WNK1 (Clone M42-P3B10)
Background Info:	WNK1 is a cytoplasmic serine-threonine kinase involved in the regulation of electrolyte homeostasis, cell signalling, survival, and proliferation. It is part of the ERK5 MAP kinase pathway and acts as an activator of sodium-coupled chloride cotransporters such as SCNN1A, SCNN1B, SCNN1D and SGK1 and as an inhibitor of WNK4 by phosphorylation or through an interaction with the WNK1 autoinhibitory domain. WNK1 may also play a role in actin cytoskeletal reorganisation. Defects in WNK1 are a cause of Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II - PHAII) an autosomal dominant disease characterised by severe hypertension and sensory and autonomic neuropathy type 2A (HSAN2A), a form of congenital sensory and autonomic neuropathy. Homologs of this WNK1 have been found in Arabidopsis thaliana, C. elegans, Chlamydomonas reinhardtii and Vitis vinifera as well as in vertebrates including Danio rerio and Taeniopygia guttata. This antibody was validated with HEK 293T cell lysate and HeLa cell lysate (1 in 1000 in 5% BSA)
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	100 µg in 100 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human
Expected Species:	Mouse , Rat, Chicken, Duck, Hamster, Goat, Sheep, Cow, Dog, Cat, Pig and Horse. If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from the C-terminal region of Human WNK1 - Ovalbumin Conjugated (The selected sequence is highly conserved across many species).
Applications:	ELISA ¦ IHC ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone M42-P3B10
Antibody Isotype:	IgG1 kappa
Application Details:	WB 1:1000 in 5% BSA, IHC 1:50-1:500
Category:	Primary Antibodies
Other names:	WNK1, Erythrocyte 65 kDa protein, Human Accelerated Region 5, WNK Lysine Deficient Protein Kinase 1, hWNK1
Research Areas:	Cell Signalling, Neuroscience
NS Reagents Product Area:	Cell Signalling
Peptide Sequence (Internal Use only):	Peptide sequence (KSISNPPGSN) aa 2369-2378 The immunogen peptide was selected from the C-terminal region of Human WNK1. The sequence is highly conserved across many species including mouse, rat, chicken, duck, hamster, goat, sheep, cow, dog, pig and horse. Full length protein is 2382 aa in length 10 20 30 40 50 MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR 60 70 80 90 100 TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL 110 120 130 140 150 SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG 160 170 180 190 200 PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ 210 220 230 240 250 QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 260 270 280 290 300 ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 310 320 330 340 350 TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 360 370 380 390 400 KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 410 420 430 440 450 ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 460 470 480 490 500 EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 510 520 530 540 550 KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 560 570 580 590 600 HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSLK QQVEQSSASQ 610 620 630 640 650 TGIKQLPSAS TGIPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL 660 670 680 690 700 SDGTVDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTV PGHIPSTVQA 710 720 730 740 750 QSQPHGVYPP SSVAQGQSQG QPSSSSLTGV SSSQPIQHPQ QQQGIQQTAP 760 770 780 790 800 PQQTVQYSLS QTSTSSEATT AQPVSQPQAP QVLPQVSAGK QLPVSQPVPT 810 820 830 840 850 IQGEPQIPVA TQPSVVPVHS GAHFLPVGQP LPTPLLPQYP VSQIPISTPH 860 870 880 890 900 VSTAQTGFSS LPITMAAGIT QPLLTLASSA TTAAIPGVST VVPSQLPTLL 910 920 930 940 950 QPVTQLPSQV HPQLLQPAVQ SMGIPANLGQ AAEVPLSSGD VLYQGFPPRL 960 970 980 990 1000 PPQYPGDSNI APSSNVASVC IHSTVLSPPM PTEVLATPGY FPTVVQPYVE 1010 1020 1030 1040 1050 SNLLVPMGGV GGQVQVSQPG GSLAQAPTTS SQQAVLESTQ GVSQVAPAEP 1060 1070 1080 1090 1100 VAVAQTQATQ PTTLASSVDS AHSDVASGMS DGNENVPSSS GRHEGRTTKR 1110 1120 1130 1140 1150 HYRKSVRSRS RHEKTSRPKL RILNVSNKGD RVVECQLETH NRKMVTFKFD 1160 1170 1180 1190 1200 LDGDNPEEIA TIMVNNDFIL AIERESFVDQ VREIIEKADE MLSEDVSVEP 1210 1220 1230 1240 1250 EGDQGLESLQ GKDDYGFSGS QKLEGEFKQP IPASSMPQQI GIPTSSLTQV 1260 1270 1280 1290 1300 VHSAGRRFIV SPVPESRLRE SKVFPSEITD TVAASTAQSP GMNLSHSASS 1310 1320 1330 1340 1350 LSLQQAFSEL RRAQMTEGPN TAPPNFSHTG PTFPVVPPFL SSIAGVPTTA 1360 1370 1380 1390 1400 AATAPVPATS SPPNDISTSV IQSEVTVPTE EGIAGVATST GVVTSGGLPI 1410 1420 1430 1440 1450 PPVSESPVLS SVVSSITIPA VVSISTTSPS LQVPTSTSEI VVSSTALYPS 1460 1470 1480 1490 1500 VTVSATSASA GGSTATPGPK PPAVVSQQAA GSTTVGATLT SVSTTTSFPS 1510 1520 1530 1540 1550 TASQLCIQLS SSTSTPTLAE TVVVSAHSLD KTSHSSTTGL AFSLSAPSSS 1560 1570 1580 1590 1600 SSPGAGVSSY ISQPGGLHPL VIPSVIASTP ILPQAAGPTS TPLLPQVPSI 1610 1620 1630 1640 1650 PPLVQPVANV PAVQQTLIHS QPQPALLPNQ PHTHCPEVDS DTQPKAPGID 1660 1670 1680 1690 1700 DIKTLEEKLR SLFSEHSSSG AQHASVSLET SLVIESTVTP GIPTTAVAPS 1710 1720 1730 1740 1750 KLLTSTTSTC LPPTNLPLGT VALPVTPVVT PGQVSTPVST TTSGVKPGTA 1760 1770 1780 1790 1800 PSKPPLTKAP VLPVGTELPA GTLPSEQLPP FPGPSLTQSQ QPLEDLDAQL 1810 1820 1830 1840 1850 RRTLSPEMIT VTSAVGPVSM AAPTAITEAG TQPQKGVSQV KEGPVLATSS 1860 1870 1880 1890 1900 GAGVFKMGRF QVSVAADGAQ KEGKNKSEDA KSVHFESSTS ESSVLSSSSP 1910 1920 1930 1940 1950 ESTLVKPEPN GITIPGISSD VPESAHKTTA SEAKSDTGQP TKVGRFQVTT 1960 1970 1980 1990 2000 TANKVGRFSV SKTEDKITDT KKEGPVASPP FMDLEQAVLP AVIPKKEKPE 2010 2020 2030 2040 2050 LSEPSHLNGP SSDPEAAFLS RDVDDGSGSP HSPHQLSSKS LPSQNLSQSL 2060 2070 2080 2090 2100 SNSFNSSYMS SDNESDIEDE DLKLELRRLR DKHLKEIQDL QSRQKHEIES 2110 2120 2130 2140 2150 LYTKLGKVPP AVIIPPAAPL SGRRRRPTKS KGSKSSRSSS LGNKSPQLSG 2160 2170 2180 2190 2200 NLSGQSAASV LHPQQTLHPP GNIPESGQNQ LLQPLKPSPS SDNLYSAFTS 2210 2220 2230 2240 2250 DGAISVPSLS APGQGTSSTN TVGATVNSQA AQAQPPAMTS SRKGTFTDDL 2260 2270 2280 2290 2300 HKLVDNWARD AMNLSGRRGS KGHMNYEGPG MARKFSAPGQ LCISMTSNLG 2310 2320 2330 2340 2350 GSAPISAASA TSLGHFTKSM CPPQQYGFPA TPFGAQWSGT GGPAPQPLGQ 2360 2370 2380 FQPVGTASLQ NFNISNLQKS ISNPPGSNLR TT
Molecular Weight:	65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cytoplasm
Purification:	Protein A Affinity Purified
Uniprot ID:	Q9H4A3
Gene ID:	65125
Gene symbol:	WNK1
Release Date:	October 2017

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Product Search Results: AX17-10003

Product Search Results: AX17-10003

Anti-WNK1 Antibody

Anti-WNK1 Antibody