Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Antibody Number:
10056
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Antibody Number:
10056
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
1. Fecto, F. et al. SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch. Neurol. 68, 14401446 (2011).
Uniprot ID:
Q13501
Gene ID:
8878
Gene symbol:
SQSTM1
Release Date:
Oct-18
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