Proteasome subunit beta type-4 (PSMB4) is an essential subunit that contributes to the assembly of the 20S proteasome complex. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. PSMB4 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Among proteasome family members, proteasome beta-4 subunit (PSMB4) is well established because it functions predominantly as regulating the assembly of the proteasome [1, 2]. PSMB4 was identified as the first proteasomal subunit with oncogenic properties promoting cancer cell survival and tumor growthin vivo [3]. PSMB4 is significantly associated with neuronal apoptosis in neuroinflammation [4].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10052
Category:
Primary Antibodies
Other names:
HN3, HsN3, PROS-26, PROS26
Research Areas:
Neuroscience, Transcription and Translation, Protein Modification, Transcription, Chromatin, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K, Murata S (2008) Dissecting beta-ring assembly pathway of the mammalian 20 S proteasome. EMBO J 27(16):22042213. doi:10.1038/emboj.2008.148 [2] Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10(2):104115. doi:10.1038/nrm2630 [3]. Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J, Stern H, Modrusan Z, Seshagiri S, Zhang Z, Davis D, Stokoe D, Settleman J, de Sauvage FJ, Neve RM (2014) Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 74(11):31143126. doi:10.1158/0008-5472. CAN-13-2683 [4]. Shi, J., Liu, X., Xu, C. et al. J Mol Hist (2015) 46: 457. Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.
Proteasome subunit beta type-4 (PSMB4) is an essential subunit that contributes to the assembly of the 20S proteasome complex. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. PSMB4 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Among proteasome family members, proteasome beta-4 subunit (PSMB4) is well established because it functions predominantly as regulating the assembly of the proteasome [1, 2]. PSMB4 was identified as the first proteasomal subunit with oncogenic properties promoting cancer cell survival and tumor growthin vivo [3]. PSMB4 is significantly associated with neuronal apoptosis in neuroinflammation [4].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10052
Category:
Primary Antibodies
Other names:
HN3, HsN3, PROS-26, PROS26
Research Areas:
Neuroscience, Transcription and Translation, Protein Modification, Transcription, Chromatin, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K, Murata S (2008) Dissecting beta-ring assembly pathway of the mammalian 20 S proteasome. EMBO J 27(16):22042213. doi:10.1038/emboj.2008.148 [2] Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10(2):104115. doi:10.1038/nrm2630 [3]. Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J, Stern H, Modrusan Z, Seshagiri S, Zhang Z, Davis D, Stokoe D, Settleman J, de Sauvage FJ, Neve RM (2014) Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 74(11):31143126. doi:10.1158/0008-5472. CAN-13-2683 [4]. Shi, J., Liu, X., Xu, C. et al. J Mol Hist (2015) 46: 457. Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.
Uniprot ID:
P28070
Gene ID:
5692
Gene symbol:
PSMB4
Release Date:
Oct-18
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