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Product Search Results: Anti MRP2 (ABCC2) Clone M2III-6

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Product Search Results: Anti MRP2 (ABCC2) Clone M2III-6

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Monosan MON9027C 1 ml £388.00
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Product Detail: Mouse anti-MRP2 (ABCC2), clone M2III-6 (Monoclonal)
Antibody Type: Monoclonal
Host Animal: Mouse
Species Reactivity: human
Immunogen: 202-amino acid COOH terminal end of the protein.
Applications: ICC, IHC-fr (1:20), IHC-P, FC, WB (1:20-50)
Data Sheet: PLEASE CLICK HERE TO DOWNLOAD
Additional Info: M2III-6 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-6 was raised against a bacterial fusion protein of cMOAB/MRP2, containing the 202-amino acid COOH terminal end of the protein. M2III-6 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
Antibody Isotype: IgG2a
Monosan Range: MONOSAN
Clone: M2III-6
Concentration: 100 ug/ml
Format: Protein G purified
Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide
Storage: 2-8°C
References 1: Paulusma et al. Science 1996; 271: 1126-1128
References 2: Kool et al. Cancer Res 1997; 57: 3537-3547
References 3: Scheffer et al. Cancer Res 2000; 60: 5269-5277