Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Uniprot ID:
Q96CV9
Gene ID:
10133
Gene symbol:
OPTN
Release Date:
Oct-18
Cookies:
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