| Product Detail: |
Anti-MFN2 Antibody (Polyclonal) |
| Background Info: |
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. |
| Product Type: |
NS Reagents Antibody |
| Antibody Type: |
Polyclonal |
| Format: |
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| Storage Temp: |
6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles. |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Human |
| Expected Species: |
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you. |
| Immunogen: |
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300 |
| Applications: |
WB ¦ IHC |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you. |
| Antibody Isotype: |
IgG |
| Application Details: |
WB 1:1000-4000. IHC 1:50-200 |
| Category: |
Primary Antibodies |
| Other names: |
CMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, KIAA0214, MARF, Mitofusin 2, Transmembrane GTPase MFN2 |
| Research Areas: |
Neuroscience, NSReagents Alzheimer's / Parkinson's |
| NS Reagents Product Area: |
Neuroscience |
| Peptide Sequence (Internal Use only): |
NH2-DASASEPEYMEEV-C (aa 261-273)
Full length protein is 757 aa in
10 20 30 40 50
MSLLFSRCNS IVTVKKNKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI
60 70 80 90 100
QESATFLEDT YRNAELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA
110 120 130 140 150
FFGRTSNGKS TVINAMLWDK VLPSGIGHTT NCFLRVEGTD GHEAFLLTEG
160 170 180 190 200
SEEKRSAKTV NQLAHALHQD KQLHAGSLVS VMWPNSKCPL LKDDLVLMDS
210 220 230 240 250
PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKHF FHKVSERLSR
260 270 280 290 300
PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRSQAGDR
310 320 330 340 350
IFFVSAKEVL NARIQKAQGM PEGGGALAEG FQVRMFEFQN FERRFEECIS
360 370 380 390 400
QSAVKTKFEQ HTVRAKQIAE AVRLIMDSLH MAAREQQVYC EEMREERQDR
410 420 430 440 450
LKFIDKQLEL LAQDYKLRIK QITEEVERQV STAMAEEIRR LSVLVDDYQM
460 470 480 490 500
DFHPSPVVLK VYKNELHRHI EEGLGRNMSD RCSTAITNSL QTMQQDMIDG
510 520 530 540 550
LKPLLPVSVR SQIDMLVPRQ CFSLNYDLNC DKLCADFQED IEFHFSLGWT
560 570 580 590 600
MLVNRFLGPK NSRRALMGYN DQVQRPIPLT PANPSMPPLP QGSLTQEEFM
610 620 630 640 650
VSMVTGLASL TSRTSMGILV VGGVVWKAVG WRLIALSFGL YGLLYVYERL
660 670 680 690 700
TWTTKAKERA FKRQFVEHAS EKLQLVISYT GSNCSHQVQQ ELSGTFAHLC
710 720 730 740 750
QQVDVTRENL EQEIAAMNKK IEVLDSLQSK AKLLRNKAGW LDSELNMFTH
QYLQPSR |
| Molecular Weight: |
86kDa (Intended as a general guide and does not allow for all isoforms and species variations) |
| Subcellular location: |
Cytoplasm Cell membrane, Mitochondrion outer membrane |
| Purification: |
Affinity purification |
| Uniprot ID: |
O95140 |
| Gene ID: |
9927 |
| Gene symbol: |
MFN2 |
| Release Date: |
October 2018 |
