Newmarket Scientific
Newmarket Scientific








StressMarq Biosciences


Antibodies, proteins & kits for heat shock, neuroscience and cancer research


StressMarq Biosciences provides Antibodies, Proteins and Kits for heat shock and cellular stress research with a strong overlap into many other areas including:

 

 

Apoptosis

Epigenetics

Neuroscience

Trafficking

Autophagy

Heat Shock Proteins

Oxidative Stress

Phosphorylation

Cell signaling

Ion Channels and Transporters

Organelle Markers and Scaffolds

Post-translational Modifications

 

 



StressMarq New Active Preformed Fibrils and Filaments for Neurodegeneration research

StressMarq has recently released new proteins for the study of neurodegenerative diseases including alpha synuclein, beta synuclein, gamma synuclein, tau, SOD1 and TTR.

 

Protein conformation disorders such as alpha-synucleinopathies, tauopathies, ALS and amyloidosis are characterised by the assembly of normally soluble proteins into insoluble aggregates. The use of the “preformed fibril model” where monomers are converted into preformed fibrils is gaining popularity amongst researchers to study neurodegenerative disorders such as Parkinson’s and Alzheimer’s.

 

Preformed fibrils can be used in vitro, adding them to the culture media or in vivo injecting them into the brain. Although pathological preformed fibrils can be generated from monomers, not all preformed fibrils formed are able to seed inclusions in cells/neurons.

 

However StressMarq has produced a wide range of already validated active preformed fibrils and monomers that produce consistent pathology (validated protein concentration, sedimentation assay, thioflavin T assay, electron microscopic visualisation of the fibrils) . These active preformed fibrils induce protein aggregation/biological activities both in vitro and in vivo.

 

Protocols: Cell Culture Assay, ASYN Thioflavin T Assay.

 

 

Alpha Synuclein Preformed Fibrils    Beta Synuclein Preformed Fibrils    Gamma Synuclein Preformed Fibrils

TTR Preformed Fibrils    SOD1 Preformed Fibrils    Tau Preformed Fibrils

 



Stressmarq   antibodies

StressMarq - Antibodies

 

StressMarq antibodies come in up to 24 different fluorescent/enzyme conjugates and cover a wide range of research areas. Highlighted antibodies are featured below, but we have many more so use the search box above to find your specific antibody.

 

NEW: Anti-Cell Membrane HSP70

This antibody is unique from other commercially available antibodies because it can bind to the extracellular region of cell membrane embedded HSP70 protein, allowing researchers to differentiate between intracellular and cell membrane embedded HSP70 across cancer cell types.

 

 

Other StressMarq Anti-HSP70 Antibodies

 

Anti-ERK1/2

Our Anti-ERK1/2 polyclonal antibody (Cat. No. SPC-120) was independently validated by Antibody Resource for use in western blot on human breast adenocarcinoma (MCF7 cell line) whole cell lysate and mouse embryonic fibroblast (NIH3T3 cell line) whole cell lysate at a dilution of 1:5000, with bands detected at the expected molecular weight of 38-43 kDa.

Read the full ERK1 antibody comparison report (PDF) prepared by AntibodyResource.com

 

Anti-ENaC Beta

 

Anti-Amyloid Oligomers (A11)

Questions? Contact us.

 



Stressmarq   kits

StressMarq - Kits

 

StressMarq provides enzyme immunoassay kits (EIA/ELISA) and detection kits for cell signalling and cell stress.

 

Some featured kits are listed below however we have many more, so follow the link above for the full list or search to find a specific kit.

 

Featured StressMarq Kits:

DNA/RNA Damage EIA Kit

HSP70 High-Sensitivity ELISA Kit

HO-1 ELISA Kit

HSP70 ELISA Kit

20S Proteasome Assay Kit

Ubiquitin Interact Detection Kit

 



Stressmarq   proteins

StressMarq - Proteins

 

StressMarq provides purified peptides and proteins for western blot controls and activity assays, primarily to aid research in Cellular Stress and Heat Shock Proteins.

 

Some featured proteins are listed below however we have many more, so please follow the link above for a full list of proteins or use the search box above to look for a specific protein.

 

Featured proteins:

Human HSP70 protein

Alpha Synuclein Protein

Alpha Synuclein Protein Aggregate

Active Alpha Synuclein Protein Aggregate

Active Alpha Synuclein Protein Monomer

Human HSP90 Beta protein

Human AHA1 native protein

 

 

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